Evaluation of the self-administration potential of high-density microarray patches to human skin: A preliminary study

Baker, Ben; Hacker, Elke; Siller, Greg; Lee, M; Mursaliyev, N; Forster, Angus

doi:10.1080/21645515.2023.2189409

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…For transdermal delivery systems such as microneedles, further research around MN manufacture, such as laser ablation, lithography, and micro moulding, need to be adapted for large-scale industrialised production, and good manufacturing practice protocols need to be implemented to manufacture microneedles on a large scale [165][166][167]. However, as mentioned, MNs are preferred by participants to the intramuscular injection [134,164,168]. As MNs are non-invasive and do not cause pain in the same way as conventional needles, they offer an alternative that is preferable [169].…”

Section: Future Strategies For Chrono-tailored Ddsmentioning

confidence: 99%

Chrono-tailored drug delivery systems: recent advances and future directions

Butler,

Rodgers,

Curtis

et al. 2024

Drug Deliv. and Transl. Res.

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Circadian rhythms influence a range of biological processes within the body, with the central clock or suprachiasmatic nucleus (SCN) in the brain synchronising peripheral clocks around the body. These clocks are regulated by external cues, the most influential being the light/dark cycle, in order to synchronise with the external day. Chrono-tailored or circadian drug delivery systems (DDS) aim to optimise drug delivery by releasing drugs at specific times of day to align with circadian rhythms within the body. Although this approach is still relatively new, it has the potential to enhance drug efficacy, minimise side effects, and improve patient compliance. Chrono-tailored DDS have been explored and implemented in various conditions, including asthma, hypertension, and cancer. This review aims to introduce the biology of circadian rhythms and provide an overview of the current research on chrono-tailored DDS, with a particular focus on immunological applications and vaccination. Finally, we draw on some of the key challenges which need to be overcome for chrono-tailored DDS before they can be translated to more widespread use in clinical practice. Graphical Abstract

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