Evaluation of the role of left atrial strain using two-dimensional speckle tracking echocardiography in patients with diabetes mellitus and heart failure with preserved left ventricular ejection fraction

Georgievska-Ismail, Ljubica; Zafirovska, Planinka; Hristovski, Zarko

doi:10.1177/1479164116655558

Cited by 28 publications

(21 citation statements)

References 44 publications

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“…Indeed, global PALS and PACS showed only a moderate inverse correlation with diastolic function parameters presented in Table 3 in both HF groups. These results match those observed in earlier studies of HFpEF and extend them to HFmrEF patients 17,20,21,23,34. Morris et al 20.…”

Section: Discussionsupporting

confidence: 91%

“…Several studies suggest that DD and elevated filling pressure cannot completely account for LA dysfunction and that LA fibrosis may play an important role 17,20,35. Indeed, global PALS and PACS showed only a moderate inverse correlation with diastolic function parameters presented in Table 3 in both HF groups.…”

Section: Discussionmentioning

confidence: 94%

“…LA dysfunction in HFpEF has previously been described and it has been suggested that it may contribute to its pathophysiology 12,17–21. Santos et al 18.…”

Section: Discussionmentioning

confidence: 99%

“…Assessment of LA phasic function using 2D-speckle-tracking echocardiography (2D-STE) has gained considerable attention due to its high feasibility and reproducibility14–16 and has led to the early detection of LA impairment in a number of conditions including HF 10. Recently, it has been proposed that LA dysfunction assessed by 2D-STE may play an important role in the pathophysiology of HFpEF17–21 and that LA deformation using 2D-STE predicts adverse events in the general population,22 and in HFpEF 23,24. In contrast, LA function in HFmrEF has not been previously investigated, and whether LA phasic function differs between HFmrEF and HFpEF is unknown.…”

Section: Introductionmentioning

confidence: 99%

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Left atrial function in heart failure with mid-range ejection fraction differs from that of heart failure with preserved ejection fraction: a 2D speckle-tracking echocardiographic study

Saikhan

Hughes

Chung

et al. 2018

European Heart Journal - Cardiovascular Imaging

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Aims Heart failure (HF) with mid-range ejection fraction (HFmrEF) shares similar diagnostic criteria to HF with preserved ejection fraction (HFpEF). Whether left atrial (LA) function differs between HFmrEF and HFpEF is unknown. We, therefore, used 2D-speckle-tracking echocardiography (2D-STE) to assess LA phasic function in patients with HFpEF and HFmrEF. Methods and results Consecutive outpatients diagnosed with HF according to current European recommendations were prospectively enrolled. There were 110 HFpEF and 61 HFmrEF patients with sinus rhythm, and 37 controls matched by age. LA phasic function was analysed using 2D-STE. Peak-atrial longitudinal strain (PALS), peak-atrial contraction strain (PACS), and PALS−PACS were measured reflecting LA reservoir, pump, and conduit function, respectively. Among HF groups, most of left ventricular (LV) diastolic function measures, and LA volume were similar. Both HF groups had abnormal LA phasic function compared with controls. HFmrEF patients had worse LA phasic function than HFpEF patients even among patients with LA enlargement. Among patients with normal LA size, LA reservoir, and pump function remained worse in HFmrEF. Differences in LA phasic function between HF groups remained significant after adjustment for confounders. Global PALS and PACS were inversely correlated with brain natriuretic peptide, LA volume, E/A, E/e′, pulmonary artery systolic pressure, and diastolic dysfunction grade in both HF groups. Conclusion LA phasic function was worse in HFmrEF patients compared with those with HFpEF regardless of LA size, and independent of potential confounders. These differences could be attributed to intrinsic LA myocardial dysfunction perhaps in relation to altered LV function.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 94%

“…LA dysfunction in HFpEF has previously been described and it has been suggested that it may contribute to its pathophysiology 12,17–21. Santos et al 18.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Left atrial function in heart failure with mid-range ejection fraction differs from that of heart failure with preserved ejection fraction: a 2D speckle-tracking echocardiographic study

Saikhan

Hughes

Chung

et al. 2018

European Heart Journal - Cardiovascular Imaging

View full text Add to dashboard Cite

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“…fibrilação atrial 64,[110][111][112][113] , estenose aórtica 114,115 , amiloidose 116 , síndrome coronária aguda 65,86,117 , pericardite constrictiva 118 e IC com fração de ejeção preservada [119][120][121][122] 10 REFERÊNCIAS…”

Section: Variáveis Ecocardiográficasunclassified

Avaliação ecocardiográfica da função do átrio esquerdo como marcadora de eventos em pacientes com insuficiência cardíaca

Sousa¹

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Left atrial phasic function and heart rate variability in asymptomatic diabetic patients

et al. 2017

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LA phasic function and cardiac autonomic nervous system assessed by HRV are impacted by diabetes. HbA1c and HRV are independently associated with LA reservoir function evaluated by volumetric and strain methods in the whole study population. This study emphasizes the importance of determination of LA function and HRV as important markers of preclinical cardiac damage and autonomic function impairment in diabetic patients.

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Evaluation of the role of left atrial strain using two-dimensional speckle tracking echocardiography in patients with diabetes mellitus and heart failure with preserved left ventricular ejection fraction

Cited by 28 publications

References 44 publications

Left atrial function in heart failure with mid-range ejection fraction differs from that of heart failure with preserved ejection fraction: a 2D speckle-tracking echocardiographic study

Left atrial function in heart failure with mid-range ejection fraction differs from that of heart failure with preserved ejection fraction: a 2D speckle-tracking echocardiographic study

Avaliação ecocardiográfica da função do átrio esquerdo como marcadora de eventos em pacientes com insuficiência cardíaca

Left atrial phasic function and heart rate variability in asymptomatic diabetic patients

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