Evaluation of the role of spectral-domain optical coherence tomography in the early detection of macular and ganglion cell complex thickness changes in patients with rheumatologic diseases taking hydroxychloroquine

Kurna, Sevda Aydın; Kanar, Hatice Selen; Garlı, Murat; Çakır, Necati

doi:10.1016/j.pdpdt.2022.102741

Cited by 1 publication

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References 38 publications

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“…Salam et al found that all OCT measurements were decreased (p<0.001) in HCQ patients, including GCC thickness, compared to the control group, which were similar to our study [27]. Kurna et al found that all GCC parameters detected by OCT were decreased in HCQ patients [28].…”

Section: Discussionsupporting

confidence: 90%

Decreased perifoveal ganglion cell complex thickness - a first sign for macular damage in patients using hydroxychloroquine

2023

rjo

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Aim: To examine ganglion cell complex (GCC) thickness detected by optical coherence tomography (OCT) in patients using hydroxychloroquine (HCQ), without any structural and functional macular changes to evaluate the initial symptoms of macular toxicity for early diagnosis before clinical evaluation. Methods: Eighty eyes of forty patients (Group 1) and forty eyes of twenty healthy volunteer persons (Group 2) were included in the study. Detailed ophthalmologic and mydriatic fundus examination were applied to all patients and volunteers (controls). Spectral domain OCT, visual field (VF) and color vision test were performed. Measurements of macula thickness, GCC thickness (involving nerve fiber layer, ganglion cell layer and inner plexiform layer) and peripapillary retinal nerve fiber layer (RNFL) were performed with OCT. Patients with retinal pigment epithelial changes, VF paracentral scotoma and defected color vision were excluded from the planned study. Results: Perifoveal GCC layer thickness in all quadrants was significantly thinner in group 1 compared to group 2 (p=0.017, p=0.001, p=0.019, p=0.001). The mean global inferior hemifield and nasal quadrant RNFL thickness were lower than in the control groups (p=0,012, p=0,009, p=0,005, respectively). Conclusion: Changes in the thickness of nerve fiber layer and ganglion cell layer detected by optical coherence tomography can be thought to be used as a diagnostic aid for the early diagnosis of hydroxychloroquine-toxic maculopathy Abbreviations: GCC = Ganglion cell complex, OCT = Optical coherence tomography, HCQ = Hydroxychloroquine, BCVA = Best-corrected visual acuity, IOP = Intraocular pressure, VF = Visual field, RNFL = Retinal nerve fiber layer, SD OCT = Spectral-domain optical coherence tomography, mfERG = Multifocal electroretinogram, FAF = Fundus autofluorescence, IS/ OS = Inner segment-outer segment junction, SITA = Swedish Interactive Threshold Algorithm, RA = Rheumatoid arthritis, SLE = Systemic lupus erythematosus, SS = Sjogren syndrome

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Section: Discussionsupporting

confidence: 90%

Decreased perifoveal ganglion cell complex thickness - a first sign for macular damage in patients using hydroxychloroquine

2023

rjo

View full text Add to dashboard Cite

show abstract

Evaluation of the role of spectral-domain optical coherence tomography in the early detection of macular and ganglion cell complex thickness changes in patients with rheumatologic diseases taking hydroxychloroquine

Cited by 1 publication

References 38 publications

Decreased perifoveal ganglion cell complex thickness - a first sign for macular damage in patients using hydroxychloroquine

Decreased perifoveal ganglion cell complex thickness - a first sign for macular damage in patients using hydroxychloroquine

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