Evaluation of the Role of hsa-mir-124 in Predicting Clinical Outcome in Breast Invasive Carcinoma Based on Bioinformatics Analysis

Abstract

Purpose. Breast invasive carcinoma (BRCA) is the most common malignant tumor. MiR-124 plays a tumor-suppressive role in human cancer. However, the clinical significance of miR-124 in BRCA remains unclear. The aim of this study was to evaluate the association of hsa-mir-124 expression and the clinicopathological characteristics in BRCA using database analysis. Methods. The clinical data and expression profiles of hsa-mir-124 were obtained from the cancer genome atlas for BRCA (TCGA_BRCA). Then, the prognostic value of hsa-mir-124 in BRCA was investigated using the Cox Regression test, and the association of hsa-mir-124 and pathology TNM stages and pathologic stages were measured by the Kruskal–Wallis test and Wilcox. test. In addition, the association of hsa-mir-124 and tumor molecular phenotypes was performed using the Chi-Square test. Results. We found that the overall survival of patients with high expression of hsa-mir-124-1 and hsa-mir-124-2 was better than that of patients with low expression of hsa-mir-124-1 and hsa-mir-124-2. And the expression of hsa-mir-124-1, hsa-mir-124-2, and hsa-mir-124-3 was mainly enriched in T1/T2 stages, NO/N1 stages, and M0 stages. Then, the expression of hsa-mir-124-1, hsa-mir-124-2, and hsa-mir-124-3 was negatively associated with tumor lymph node metastasis. Moreover, the expression of hsa-mir-124 was associated with tumor molecular phenotype in breast invasive carcinoma. Conclusion. Our findings indicated that hsa-mir-124 expressions were associated with overall survival, TNM stages, pathologic characteristics, and tumor molecular phenotype in BRCA via TCGA_BRCA database, providing a new biomarker and a potential therapeutic target for BRCA patients.

Identification of RP11‐770J1.4 as immune‐related lncRNA regulating the CTXN1–cGAS–STING axis in histologically lower‐grade glioma

“…hsa‐miR‐124 is often methylated in hepatocellular carcinoma and gastric cancer 50,53 . Abnormal hsa‐miR‐124 expression adversely impacts clinical outcomes, consistent with existing literature 49,54,55 . Survival analysis of factors in the ceRNA network substantiates the prognostic significance of lncRNAs AC016738.4 and RP11‐770J1.4.…”

“…50,53 Abnormal hsa-miR-124 expression adversely impacts clinical outcomes, consistent with existing literature. 49,54,55 Survival analysis of factors in the ceRNA network substantiates the prognostic significance of lncRNAs AC016738.4 and RP11-770J1.4. Specifically, overexpression of lncRNA AC016738.4 is linked to diminished OS and relapse-free survival times in esophageal cancer, 56 establishing its potential as a biomarker for pancreatic ductal adenocarcinoma.…”

Predictive and Prognostic Value of Non-coding RNA in Breast Cancer

“…There was a negative association between has-mir-124-1 and has-mir-124-2, has-mir-124-3 and lymph node metastasis. Overall, has-mir-124 was associated with worse clinical outcomes and could be used as a biomarker for BRCA [83].…”

Predictive and Prognostic Value of Non-Coding RNA in Breast Cancer

“…There was a negative association between has-mir-124-1 and has-mir-124-2, has-mir-124-3 and lymph node metastasis. Overall, has-mir-124 was associated with worse clinical outcomes and could be used as a biomarker for BRCA [ 90 ].…”