Evaluation of the Role of ALDH1 as Cancer  Stem Cell Marker in Colorectal Carcinoma:  An Immunohistochemical Study

Holah, Nanis Shawky

doi:10.7860/jcdr/2017/22671.9291

Cited by 26 publications

(24 citation statements)

References 36 publications

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“…ALDH1‐positive tumour cells from primary OSCC were predominantly detected around blood vessels, being significantly correlated with angiolymphatic invasion ( P = .0184). Indeed, previous studies with breast and colorectal cancer also associated high expression of ALDH1 with vascular invasion. In fact, it is known that ALDH1 activity is associated with EMT program in cancer cells, which contributes to tumour progression and metastasis through the disruption of basement membrane and invasion into the stroma, such as the lymph and blood vascular systems …”

Section: Discussionmentioning

confidence: 84%

CD44 and ALDH1 immunoexpression as prognostic indicators of invasion and metastasis in oral squamous cell carcinoma

Ortiz

Lopes

Amôr

et al. 2018

J Oral Pathology Medicine

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Section: Discussionmentioning

confidence: 84%

CD44 and ALDH1 immunoexpression as prognostic indicators of invasion and metastasis in oral squamous cell carcinoma

Ortiz

Lopes

Amôr

et al. 2018

J Oral Pathology Medicine

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“…(15) Moreover, ALDH is upregulated in several types of CSC. (27,28) Therefore, ALDH has been used as a stem cell marker.…”

Section: Discussionmentioning

confidence: 99%

Tumor endothelial cells with high aldehyde dehydrogenase activity show drug resistance

et al. 2017

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Tumor blood vessels play an important role in tumor progression and metastasis. We previously reported that tumor endothelial cells (TEC) exhibit several altered phenotypes compared with normal endothelial cells (NEC). For example, TEC have chromosomal abnormalities and are resistant to several anticancer drugs. Furthermore, TEC contain stem cell‐like populations with high aldehyde dehydrogenase (ALDH) activity (ALDH high TEC). ALDH high TEC have proangiogenic properties compared with ALDH low TEC. However, the association between ALDH high TEC and drug resistance remains unclear. In the present study, we found that ALDH mRNA expression and activity were higher in both human and mouse TEC than in NEC. Human NEC:human microvascular endothelial cells (HMVEC) were treated with tumor‐conditioned medium (tumor CM). The ALDH high population increased along with upregulation of stem‐related genes such as multidrug resistance 1, CD90, ALP, and Oct‐4. Tumor CM also induced sphere‐forming ability in HMVEC. Platelet‐derived growth factor (PDGF)‐A in tumor CM was shown to induce ALDH expression in HMVEC. Finally, ALDH high TEC were resistant to fluorouracil (5‐FU) in vitro and in vivo. ALDH high TEC showed a higher grade of aneuploidy compared with that in ALDH low TEC. These results suggested that tumor‐secreting factor increases ALDH high TEC populations that are resistant to 5‐FU. Therefore, ALDH high TEC in tumor blood vessels might be an important target to overcome or prevent drug resistance.

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“…ALDH1 expression is associated with colon cancer location [73], with advanced stages of the disease [75], with number of lymph nodes involved (N) [73,75,76], and with perivenous invasion (V) [73] but also with local tumor recurrence [75]. The association between ALDH1 expression and lymph node involvement was not seen by Zhou et al [74].…”

Section: Author Detailsmentioning

confidence: 99%

Section: Aldh1mentioning

confidence: 99%

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Stem Cell Markers in Colon Cancer

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Basic Principles and Practice in Surgery

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Colon cancer incidence is increasing in young people. Even if, so far, colon cancer had a maximum incidence in the sixth and seventh decades of life, lately its incidence in people age 50 and younger is increasing. Thus, colon cancer still represents a major health problem despite constant research made in the field. Early detection of colon cancer is mandatory for an appropriate treatment of the disease and to attain increased overall survival. Even if various stem cell markers have been studied in order to evaluate their prognostic value in colon cancer cases, results in literature are heterogeneous, and no clear consensus has been drafted so far. This paper aims to review the most important stem cell markers identified in colon cancer and to establish their role in both cancer diagnosis and progression.

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Evaluation of the Role of ALDH1 as Cancer Stem Cell Marker in Colorectal Carcinoma: An Immunohistochemical Study

Cited by 26 publications

References 36 publications

CD44 and ALDH1 immunoexpression as prognostic indicators of invasion and metastasis in oral squamous cell carcinoma

CD44 and ALDH1 immunoexpression as prognostic indicators of invasion and metastasis in oral squamous cell carcinoma

Tumor endothelial cells with high aldehyde dehydrogenase activity show drug resistance

Stem Cell Markers in Colon Cancer

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