Evaluation of The Rice Breath Hydrogen Test for Small Intestinal Bacterial Overgrowth

Riordan, Stephen M.; McIver, Christopher J.; Duncombe, V. M.; Thomas, M.; Bolin, T. D.

doi:10.1111/j.1572-0241.2000.02317.x

Cited by 103 publications

(133 citation statements)

References 25 publications

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“…The status of cholecystectomy is related with rapid intestinal transit. During the lactulose breath test, it is difficult to distinguish SIBO from colonic bacteria in case of rapid intestinal transit, 10,26,27 and importantly lactulose itself induces rapid small bowel transit. 28 In addition, the advantages of breath test using glucose over lactulose as the substrate for the breath test are low false positivity and superiority of diagnosing SIBO.…”

Section: Discussionmentioning

confidence: 99%

Small Intestinal Bacterial Overgrowth Diagnosed by Glucose Hydrogen Breath Test in Post-cholecystectomy Patients

Sung

Paik

Chung

et al. 2015

J Neurogastroenterol Motil

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Background/AimsPatients undergoing cholecystectomy may have small intestinal bacterial overgrowth (SIBO). We investigated the prevalence and characteristics of SIBO in patients with intestinal symptoms following cholecystectomy. MethodsSixty-two patients following cholecystectomy, 145 with functional gastrointestinal diseases (FGIDs), and 30 healthy controls undergoing hydrogen (H2)-methane (CH4) glucose breath test (GBT) were included in the study. Before performing GBT, all patients were interrogated using bowel symptom questionnaire. The positivity to GBT indicating the presence of SIBO, gas types and bowel symptoms were surveyed. ResultsPost-cholecystectomy patients more often had SIBO as evidenced by a positive (+) GBT than those with FGID and controls (29/62, 46.8% vs 38/145, 26.2% vs 4/30, 13.3%, respectively; P = 0.010). In the gas types, the GBT (H2) + post-cholecystectomy patients was significantly higher than those in FGIDs patients (P = 0.017). Especially, positivity to fasting GBT (H2) among the GBT (H2)+ post-cholecystectomy patients was high, as diagnosed by elevated fasting H2 level. The GBT+ group had higher symptom scores of significance or tendency in abdominal discomfort, bloating, chest discomfort, early satiety, nausea, and tenesmus than those of the GBT negative group. The status of cholecystectomy was the only significant independent factor for predicting SIBO. ConclusionsThe SIBO with high levels of baseline H2 might be the important etiologic factor of upper GI symptoms for post-cholecystectomy patients. (J Neurogastroenterol Motil 2015;21:545-551)

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Section: Discussionmentioning

confidence: 99%

Small Intestinal Bacterial Overgrowth Diagnosed by Glucose Hydrogen Breath Test in Post-cholecystectomy Patients

Sung

Paik

Chung

et al. 2015

J Neurogastroenterol Motil

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“…Using lactulose breath tests (LBT), Pimental and colleagues showed that 78% of IBS patients had SIBO [128] and that eradication with a seven-day course of neomycin was associated with a significant reduction in symptoms [129] . However, these results are somewhat controversial, as both the accuracy of the LBT and its ability to gauge treatment response has been questioned [130][131][132][133] . More recently, Posserud and colleagues conducted a study of 162 IBS patients using cultures of jejunal aspirates to detect SIBO [134] .…”

Section: Antibioticsmentioning

confidence: 99%

Updates on treatment of irritable bowel syndrome

Hammerle¹,

Surawicz²

2008

WJG

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Irritable bowel syndrome (IBS) is a highly prevalent gastrointestinal disorder characterized by abdominal pain and discomfort in association with altered bowel habits. It is estimated to affect 10%-15% of the Western population, and has a large impact on quality of life and (in)direct healthcare costs. IBS is a multifactorial disorder involving dysregulation within the brain-gut axis, and it is frequently associated with gastrointestinal motor and sensory dysfunction, enteric and central nervous system irregularities, neuroimmune dysregulation, and postinfectious inflammation. As with other functional medical disorders, the treatment for IBS can be challenging. Conventional therapy for those with moderate to severe symptoms is largely unsatisfactory, and the development of new and effective drugs is made difficult by the complex pathogenesis, variety of symptoms, and lack of objective clinical findings that are the hallmark of this disorder. Fortunately, research advances over the past several decades have provided insight into potential mechanisms responsible for the pathogenesis of IBS, and have led to the development of several promising pharmaceutical agents. In recent years there has been much publicity over several of these new IBS medications (alosetron and tegaserod) because of their reported association with ischemic colitis and cardiovascular disease. While these agents remain available for use under restricted prescribing programs, this highlights the need for continued development of safe and effective medication for IBS. This article provides a physiologicallybased overview of recently developed and frequently employed pharmaceutical agents used to treat IBS, and discusses some non-pharmaceutical options that may be beneficial in this disorder.

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“…We suspect that the bacterial overgrowth in the small intestine occurred among the subjects of "pattern A", because it results in a similar pronounced breath hydrogen excretion as that of "pattern A" in serial breath hydrogen collection (Riordan et al, 1995). Breath hydrogen test has been widely applied for diagnosing small intestinal bacterial overgrowth as a noninvasive alternative to culture of small intestinal aspirate.…”

Section: Discussionmentioning

confidence: 99%

Everyday Breath Hydrogen Excretion Profile in Japanese Young Female Students.

Sone

Tanida

Matsubara

et al. 2000

J. Physiol. Anthropol.

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A breath hydrogen test has been used widely as a noninvasive and simple method of detecting carbohydrate malabsorption as well as estimation of the small intestinal and orocecal transit time. By means of this method, we have examined the change in breath hydrogen concentration of young female students in their everyday life in order to reveal the breath hydrogen excretion profile under normal circumstances. In this survey, we have asked them to collect their own breath samples every one-hour as regularly as possible during one day from awakening until bedtime. We also asked them to complete the questionnaire concerning their dietary habit, dietary record and physical activities. Among the 43 subjects who gave the breath hydrogen records, 37 subjects excreted detectable hydrogen into their alveolar air. By comparing the changes in breath hydrogen concentration during the time of day, breath hydrogen excretions could be classified into two distinct patterns; more than half of the total hydrogen excretion occurred in the first half of the waking hours (designated as "pattern A", 18 cases) and in the latter half (designated as "pattern B", 19 cases). Taking into consideration the subjects' records of diets and physical activities, the earlypronounced breath hydrogen excretion observed among 18 "pattern A" students was probably resulted from the malabsorption of the dietary carbohydrate in the breakfast meals.

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Evaluation of The Rice Breath Hydrogen Test for Small Intestinal Bacterial Overgrowth

Abstract: Clinical value of the rice breath hydrogen test for detecting small intestinal bacterial overgrowth is limited. The rice breath hydrogen test is not a suitable alternative to small intestinal intubation and culture of secretions for the detection of small intestinal bacterial overgrowth.

Cited by 103 publications

References 25 publications

Small Intestinal Bacterial Overgrowth Diagnosed by Glucose Hydrogen Breath Test in Post-cholecystectomy Patients

Small Intestinal Bacterial Overgrowth Diagnosed by Glucose Hydrogen Breath Test in Post-cholecystectomy Patients

Updates on treatment of irritable bowel syndrome

Everyday Breath Hydrogen Excretion Profile in Japanese Young Female Students.

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