Evaluation of the retinal ganglion cell and choroidal thickness in young Turkish adults with hyperopic anisometropic amblyopia

Çelik, Erkan; Çakır, Burçin; Türkoğlu, Elif Betül; Doğan, Emine; Alagöz, Gürsoy

doi:10.1007/s10792-015-0157-4

Cited by 21 publications

(19 citation statements)

References 28 publications

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“…In adults with anisometropic amblyopia, there was no significant difference in the subfoveal choroidal thickness between amblyopic and fellow or control eyes. [ 17 , 18 ] In children, the choroid may have greater flexibility compared to that in adults. We found that amblyopic eyes had larger luminal areas than that of normal children.…”

Section: Discussionmentioning

confidence: 99%

Choroidal Structure in Children with Anisohypermetropic Amblyopia Determined by Binarization of Optical Coherence Tomographic Images

et al. 2016

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PurposeTo compare the choroidal structure of the subfoveal area in the eyes of children with anisohypermetropic amblyopia to that of the fellow eyes and to age-matched controls using a binarization method of the images obtained by enhanced depth imaging optical coherence tomography (EDI-OCT).MethodsThis study was performed at Nara Medical University Hospital, Tokushima University Hospital, and Kagoshima University Hospital, Japan. Forty amblyopic eyes with anisohypermetropic amblyopia and their fellow eyes (5.9 ± 2.1 years, mean ± standard deviation), and 103 age-matched controls (6.7 ± 2.4 years) were studied. The control eyes were divided into myopic, emmetropic, and hyperopic eyes. The total choroidal area, luminal area and stromal area of the subfoveal choroid were measured by the binarization method. The luminal/stromal ratio and the axial length of the amblyopic eyes were compared to that of the control eyes.ResultsThe total choroidal area in the amblyopic eyes was significantly larger than that of the fellow eyes (P = 0.005). The luminal/stromal ratio was significantly larger in the amblyopic eyes than that of the fellow eyes (P<0.001) and the control hyperopic eyes (P<0.001). There was a significant negative correlation between the luminal/stromal ratio and the axial length in the control eyes (r = -0.30, P = 0.001), but no significant correlation was found in the amblyopic eyes.ConclusionsThe choroidal structure of the amblyopic eyes was different from that of the fellow and the control hyperopic eyes. The choroidal changes are related to amblyopia.

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Section: Discussionmentioning

confidence: 99%

Choroidal Structure in Children with Anisohypermetropic Amblyopia Determined by Binarization of Optical Coherence Tomographic Images

et al. 2016

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“…A large number of studies have recently used SD-OCT to assess the thickness of the retina [ 11 ] or choroid [ 13 , 16 – 22 ] in unilateral amblyopia. However, none of the previous reports have used SS-OCT to analyze the retinal and choroidal thickness at the same time.…”

Section: Discussionmentioning

confidence: 99%

“…However, none of the previous reports have used SS-OCT to analyze the retinal and choroidal thickness at the same time. Furthermore, these previous studies manually performed the choroidal thickness measurements only at specific points and not over defined areas [ 13 , 16 – 22 ]. Thus, the current study is the first to use SS-OCT to evaluate the averaged regional retinal and choroidal thickness in unilateral amblyopia using a 3D map.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies that used SD-OCT to evaluate the inner retinal thickness reported finding no significant differences in the GCL+IPL or GCC thicknesses between the amblyopic eyes and the fellow and normal control eyes [ 16 , 27 – 29 ]. In contrast, Park et al [ 30 ] reported that the GCL+IPL thickness was thinner in amblyopic eyes versus the fellow eyes.…”

Section: Discussionmentioning

confidence: 99%

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Macular retinal and choroidal thickness in unilateral amblyopia using swept-source optical coherence tomography

et al. 2017

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BackgroundTo investigate macular retinal and choroidal thickness in amblyopic eyes compared to that in fellow and normal eyes using swept-source optical coherence tomography (SS-OCT).MethodsThis study examined 31 patients with hyperopic anisometropic amblyopia (6.9 ± 3.8 years, mean ± standard deviation), 15 patients with strabismic amblyopia without anisometropia (7.9 ± 4.2 years), and 24 age-matched controls (7.8 ± 3.3 years). Retinal and choroidal thickness was measured by 3D scans using SS-OCT. A 6-mm area around the fovea was automatically analyzed using the Early Treatment Diabetic Retinopathy Study map. The thickness from SS-OCT was corrected for magnification error using individual axial length, spherical refraction, cylinder refraction, and corneal radius. Retinal thickness was divided into the macular retinal nerve fiber layer (mRNFL), ganglion cell layer + inner plexiform layer (GCL+IPL), ganglion cell complex (GCC), and the inner limiting membrane to the retinal pigment epithelium (ILM-RPE) thickness. Retinal and choroidal thickness was compared among amblyopic, fellow, and normal eyes.ResultsIn both amblyopia groups, there was no significant difference in the mRNFL, GCL+IPL, and GCC thicknesses among the amblyopic, fellow, and control eyes. In the anisometropic amblyopia group, choroidal thickness (subfovea, center 1 mm, nasal and inferior of the inner ring, nasal of the outer ring, and center 6 mm) of amblyopic eyes were significantly greater than that of fellow and normal eyes. In contrast, none of the choroidal thicknesses were significantly different among the investigated eyes in the strabismic amblyopia group.ConclusionsWe found no significant difference in inner retinal thickness in patients with unilateral amblyopia. Although there were significant differences in choroidal thickness with hyperopic anisometropic amblyopia, there was no significant difference for the strabismic amblyopia. The discrepancy in choroidal thickness between the two types of amblyopia may be due to both differences in ocular size and underlying mechanism.

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“…We have read the article entitled as ''Evaluation of the retinal ganglion cell and choroidal thickness in young Turkish adults with hyperopic anisometropic amblyopia'' by Celik et al [1] with great interest. The authors investigated the choroidal thickness (CT) and ganglion cell complex (GCC) thickness of the normal fellow eyes and the amblyopic eyes using enhanced depth imaging optical coherence tomography (EDI-OCT) in 43 young Turkish adults with hyperopic anisometropic amblyopia.…”

Section: Dear Editormentioning

confidence: 99%