Order of Authors: federico cullati; francesca m rusconi; andrea mapelli; matteo zago; giada a beltramini; aldo b gianni'; chiarella sforza, MD, PhD Manuscript Region of Origin: ITALY Abstract: The effect of bimaxillary orthognathic surgery on facial mimicry was longitudinally assessed in 15 patients with dentoskeletal Class III facial dysmorphosis (7 men, 8 women, mean age 28 years). The patients were analyzed pre-surgery and 6, 12 and 24 months post-surgery while performing verbal (five vowels) and nonverbal (open and closed mouth smile, lip purse) soft-tissue facial movements. The 3D motions of right and left naso-genian, crista philtri, cheilion and lower lip landmarks were detected by an optoelectronic instrument, and a total mobility index was obtained. Side differences were quantified by an index of symmetry. Patients values were compared to those previously collected in healthy volunteers by computing z-scores. On average, 24 months after surgery no significant differences were found in the mobility of the buccal soft tissues (ANOVA p values range 0.075-0.808), with positive median z-scores (pooled mean value close to 0.6). Symmetry indices ranged around the control reference values, showing no stage-related differences (Friedman test p values range 0.252-0.937), and exceeding 90% for all movements 24 months after surgery. Bimaxillary osteotomy does not compromize facial mimicry, in both verbal and nonverbal facial movements. , which I would like to submit as Research Paper for the publication in the International Journal of Oral and Maxillofacial Surgery.In the paper, we investigated the modifications in facial mimicry after orthognathic surgery using a motion capture instrument. The method of data collection had already been published by the Journal (Facial mimicry after conservative parotidectomy: A three-dimensional optoelectronic study. Int J Oral Maxillofac Surg. 2012;41:986-93; The effect of age and sex on facial mimicry: a threedimensional study in healthy adults. Int J Oral Maxillofac Surg. 2010;39:990-9).