Evaluation of the relationship between previous statin use and thyroid cancer using Korean National Health Insurance Service-Health Screening Cohort data

Abstract

The association of thyroid cancer with statin use is controversial. This study aimed to investigate the association of previous statin use with thyroid cancer in the ≥ 40-year-old population in the Korean National Health Insurance Service-Health Screening Cohort. The 5501 patients in the thyroid cancer group were matched with the 22,004 patients in the non-thyroid cancer group for age, sex, income, and region of residence. Previous statin use during the 2 years before the diagnosis of thyroid cancer was examined. The odds ratios (ORs) with 95% confidence intervals (CIs) of previous statin use for thyroid cancer were estimated using conditional logistic regression analyses. Additionally, subgroup analyses were conducted. The thyroid cancer group showed more days of previous statin use than the non-thyroid cancer group (72.3, standard deviation [SD] = 181.2 days vs. 64.3, SD = 174.4 days, P = 0.003). Although the odds of previous statin use for thyroid cancer were high in the crude model (OR = 1.10, 95% CI 1.04–1.17, P = 0.002), they were low in the fully adjusted model (OR = 0.89, 95% CI 0.82–0.95, P = 0.001). According to age and sex subgroups, the younger (< 60 years old) male group showed lower odds for thyroid cancer according to previous statin use (adjusted OR = 0.70, 95% CI 0.55–0.88, P = 0.003), but this finding was not observed in other subgroups of older men or in any groups of women. Thyroid cancer was negatively associated with statin use in the previous 2 years in the adjusted model.

A population-based cohort study of longitudinal change of high-density lipoprotein cholesterol impact on gastrointestinal cancer risk

“…Fifth, we used high-quality data from the NHISS, including direct measurement of lipids and BMI, detailed information on many covariates, and nearly complete sensing of cancer detection. Many previous studies have used data from the NHISS and validated their quality 13,14 . Finally, this national health examination cohort represents the general Korean population aged ≥40 years.…”

“…studies using the Korean NHISS have been published 13,14 . The definition of normal and low HLD-C was defined according to the Adult Treatment Panel III (ATP III) 15 .…”

“…BMI body mass index, HDL-C high density lipoprotein, IQR interquartile range. a Economic status is twentile(1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). 1 is the lowest and 20 is the highest income.…”

Big Data Research in the Field of Endocrine Diseases Using the Korean National Health Information Database

“…metformin [47], and statins [48], has shown associations with the occurrence of thyroid cancer. Associations between specific diseases and thyroid cancer have also been reported, especially in relation to sex differences, and patients with obstructive sleep apnea have also been shown to have a higher risk of incident thyroid cancer, especially in middle-aged men [49].…”

Favorable Effect of High-Density Lipoprotein Cholesterol on Gastric Cancer Mortality by Sex and Treatment Modality

“…In this large population-based cohort study, we extracted data from the Korean NHISS (REQ0000045293), which included the National General Health Examination and National Cancer Screening Program (NCSP). Several studies on cancer using the data derived from NHISS have been published [17,18]. We extracted data on the patients' sex, incomes, disease codes of the International Classification of Disease (10th revision) from T20 data (disease codes), treatment code for endoscopic and gastrectomy from T30 data (prescription and medical practice codes), presence of chronic disease, medication, smoking status (none, past, or current), alcohol consumption status, physical activity, family history, blood pressure, body mass index [BMI, weight/height 2 (kg/m 2 )], lipid levels, and fasting glucose levels from participants' questionnaires.…”