Evaluation of the Relationship between the <i>Znf804A</i> Single Nucleotide Polymorphism Rs1344706 a/c Variant and Schizophrenia Subtype in Han Chinese Patients

Yang, Yongfeng; Li, Wenqiang; Yang, Ge; Xiao, Bo; Wang, Xiujuan; Ding, Mingmin; Zhao, Jian; Song, Xueqing; Yue, Weihua; Zhang, Dai; Zhang, Hongxing; Lv, Luxian

doi:10.2190/pm.45.3.f

Cited by 12 publications

(13 citation statements)

References 19 publications

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“…Some have provided strong support for susceptibility variants in ZNF804A in schizophrenia or bipolar disorder Riley et al, 2010;Sazci et al, 2012;Schwab et al, 2013;Williams et al, 2011;Xiao et al, 2011;Yang et al, 2013;Zhang et al, 2011a), whereas others have shown a negative association (Landaas et al, 2011;Li et al, 2011;Liou et al, 2012;Thurin et al, 2013;Zaharie et al, 2012). These differences may be caused by the type of disease, ethnicity, or sample size.…”

Section: Discussionmentioning

confidence: 99%

Association between variants of zinc finger genes and psychiatric disorders: Systematic review and meta-analysis

Sun

Liang

et al. 2015

Schizophrenia Research

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Section: Discussionmentioning

confidence: 99%

Association between variants of zinc finger genes and psychiatric disorders: Systematic review and meta-analysis

Sun

Liang

et al. 2015

Schizophrenia Research

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“…In addition, our meta-analyses indicated significant association of rs1344706 with schizophrenia in Northern Chinese populations ( P = 0.005, OR = 1.09, 95% CI 1.03–1.15), i.e ., Shanxi, Xinxiang and Shandong121314, which was inconsistent with most studies conducted in either Central or Southern Chinese populations, including Jiangsu, Yunnan, Sichuan and Guangxi province15161718. This inconsistence may originate from the following several reasons.…”

Section: Discussionmentioning

confidence: 84%

“…Moreover, the MAF of rs1344706 in controls was slightly different among Northern (0.489)13, Central (0.41)9 and Southern (0.491)15 Chinese populations, which might cause between-study heterogeneity. Therefore, we conducted meta-analysis using studies from northern, central, and southern China respectively.…”

Section: Resultsmentioning

confidence: 93%

“…Following our literature search strategy, a total of 11 studies involving 15 independent samples which encompass 11573 cases and 15321 controls, as well as 101 schizophrenia trios, were identified for schizophrenia912131415161718222324, and 2 studies (including the present study) consisting of 1274 patients of BD and 1343 healthy controls was identified for BD21. Detailed information concerning the sample size and association results for each study was listed in Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…Follow-up studies conducted in different European populations have replicated this finding, suggestive that rs1344706 is probably an authentic risk SNP for schizophrenia and BD in Europeans1011. In Chinese populations, several groups have reported the association between rs1344706 and schizophrenia, subjects from which were all from northern China (Shanxi, Xinxiang and Shandong)121314. However, more studies with subjects recruited from central and Southern China ( i.e ., Jiangsu, Yunnan, Sichuan and Guangxi province) failed to replicate this association15161718.…”

mentioning

confidence: 89%

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Genetic association of rs1344706 in ZNF804A with bipolar disorder and schizophrenia susceptibility in Chinese populations

Rao

Yao

Ryan

et al. 2017

Sci Rep

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Rs1344706 in the the zinc finger protein 804A (ZNF804A) gene has been identified to be associated with schizophrenia and bipolar disorder (BD) in Europeans. However, whether rs1344706 is associated with schizophrenia in Chinese populations remains inconclusive; furthermore, the association between rs1344706 and BD in Chinese populations has been rarely explored. To explore the association between rs1344706 and schizophrenia/BD in Chinese populations, we genotyped rs1344706 among 1128 Chinese subjects (537 patients with BD and 591 controls) and found that rs1344706 showed marginal allelic association with BD (P = 0.028) with T-allele being more prevalent in cases than that in controls (OR = 1.19, 95% CI 1.03–1.37). Meta-analysis of rs1344706 by pooling all available data showed that rs1344706 was significantly associated with BD (P = 0.001). Besides, positive association of rs1344706 with schizophrenia was observed in Northern Chinese (P = 0.005). Furthermore, ZNF804A is highly expressed in human and mouse brains, especially in prenatal stage.

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Bioinformatic analyses and conceptual synthesis of evidence linking ZNF804A to risk for schizophrenia and bipolar disorder

Hess

Quinn

Akbarian

et al. 2014

American J of Med Genetics Pt B

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Advances in molecular genetics, fueled by the results of large-scale genome-wide association studies, meta-analyses, and mega-analyses, have provided the means of identifying genetic risk factors for human disease, thereby enriching our understanding of the functionality of the genome in the post-genomic era. In the past half-decade, research on neuropsychiatric disorders has reached an important milestone: the identification of susceptibility genes reliably associated with complex psychiatric disorders at genome-wide levels of significance. This age of discovery provides the groundwork for follow-up studies designed to elucidate the mechanism(s) by which genetic variants confer susceptibility to these disorders. The gene encoding zinc-finger protein 804 A (ZNF804A) is among these candidate genes, recently being found to be strongly associated with schizophrenia and bipolar disorder via one of its non-coding mutations, rs1344706. Neurobiological, molecular, and bioinformatic analyses have improved our understanding of ZNF804A in general and this variant in particular; however, more work is needed to establish the mechanism(s) by which ZNF804A variants impinge on the biological substrates of the two disorders. Here, we review literature recently published on ZNF804A, and analyze critical concepts related to the biology of ZNF804A and the role of rs1344706 in schizophrenia and bipolar disorder. We synthesize the results of new bioinformatic analyses of ZNF804A with key elements of the existing literature and knowledge base. Furthermore, we suggest some potentially fruitful short- and long-term research goals in the assessment of ZNF804A.

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Evaluation of the Relationship between the Znf804A Single Nucleotide Polymorphism Rs1344706 a/c Variant and Schizophrenia Subtype in Han Chinese Patients

Abstract: We found no evidence that the ZNF804A SNP rs1344706 is a susceptibility locus for SZ. However, conflicting results from previous association studies may be due to genetic heterogeneity between different patient SZ subtypes.

Cited by 12 publications

References 19 publications

Association between variants of zinc finger genes and psychiatric disorders: Systematic review and meta-analysis

Association between variants of zinc finger genes and psychiatric disorders: Systematic review and meta-analysis

Genetic association of rs1344706 in ZNF804A with bipolar disorder and schizophrenia susceptibility in Chinese populations

Bioinformatic analyses and conceptual synthesis of evidence linking ZNF804A to risk for schizophrenia and bipolar disorder

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