Evaluation of the relationship between circulating omentin-1 concentrations and components of the metabolic syndrome in adults without type 2 diabetes or cardiovascular disease

Abstract

BackgroundDysregulation of omentin-1, a beneficial adipokine, is thought to play a role in the development of type 2 diabetes and cardiovascular disease. The objective of this study was to evaluate the relationship between circulating omentin-1 concentrations and components of the metabolic syndrome in adults without type 2 diabetes or cardiovascular disease, and to determine if sex differences influenced the observed relationships.MethodsFasting blood samples were obtained from 93 adults, ages 30–60 years, without type 2 diabetes and/or cardiovascular disease. Participants were classified as having the metabolic syndrome according to American Heart Association/National Heart, Lung and Blood Institute criteria. Plasma omentin-1 concentrations were measured using a commercially-available enzyme-linked immunosorbent assay, and relationships between plasma omentin-1 and components of the metabolic syndrome were assessed in the entire study cohort, by metabolic syndrome status, and by sex.ResultsOn average, participants were 48 ± 8 years of age, 50.5% were women, 54.8% were Caucasian, and 70% had the metabolic syndrome. Plasma omentin-1 concentrations did not differ significantly between individuals with versus without the metabolic syndrome (145.7 ± 70 versus 157.4 ± 79.3 ng/ml, p = 0.50). However, men with the metabolic syndrome had significantly lower omentin-1 levels than men without the metabolic syndrome (129.9 ± 66 versus 186.3 ± 84.3 ng/ml, p = 0.03). Plasma omentin-1 concentrations were significantly correlated with HDL cholesterol in the entire study cohort (r = 0.26; p = 0.01), which was primarily driven by a correlation in men (r = 0.451, p = 0.002) and participants with the metabolic syndrome (r = 0.36; p = 0.003). Plasma omentin-1 concentrations did not differ significantly between men and women; however men with the metabolic syndrome had 20% lower plasma omentin-1 levels than women with the metabolic syndrome (p = 0.06).ConclusionThese data demonstrate that circulating omentin-1 levels are associated with HDL cholesterol, primarily in men and in the presence of the metabolic syndrome. In addition, sex appears to influence the relationship between plasma omentin-1 concentrations and components of the metabolic syndrome. Additional studies are needed to explore sexual dimorphism in circulating omentin-1 levels, and the role of omentin-1 in the metabolic syndrome.

Omentin serum concentration and hepatic expression in chronic hepatitis C patients – together or apart?

“…The second issue is the racial divergence in serum omentin concentration. Mean plasma omentin-1 concentrations were higher in African Americans than in Caucasians [40]. This aspect may lead to a discrepancy in the obtained results, because our study included only Caucasians, whereas the study by Nassif et al included Egyptian patients.…”

Adiponectin may mediate the association between omentin, circulating lipids and insulin sensitivity: results from the KORA F4 study

“…Our findings go beyond previous reports that were based on smaller samples and on univariate analyses. Most studies observed a positive association between omentin and HDL cholesterol (7,11,15,26,28,31), whereas the inverse association with triglycerides was found only in some (26,28), but not all (7, 11, 15, 16) samples.…”

“…Notably, the inverse relation between omentin levels on the one hand and 2-h glucose, 2-h insulin and ISI (composite), which represents an OGTT-derived measure of insulin sensitivity that is more closely related to clamp-measured insulin sensitivity than HOMA-IR (23), on the other hand remained significant after adjustment for BMI, but not after adjustment for lipids or adiponectin. Some (10,26), but not other (7,11,27,28), studies reported inverse associations between omentin and fasting glucose in univariate analyses. One study reported inverse associations with fasting glucose, 2-h glucose and HbA1c in univariate, but not in multivariate analyses (12).…”

A novel adipocytokine, omentin, inhibits platelet-derived growth factor-BB-induced vascular smooth muscle cell migration through antioxidative mechanism

“…It was also reported that blood omentin concentration decreased in the obese diabetic woman (119 ng/ml) compared with that in the nondiabetic obese woman (207 ng/ml) (17). In addition, it was reported that blood omentin concentration decreased in the men with metabolic syndrome (130 ng/ml) compared with the men without metabolic syndrome (186 ng/ml) (19). From these reports, it is considerable that the concentration of omentin used in this study is within the (patho)physiological range.…”

“…Secretion and plasma concentration of omentin decrease in the obese subjects (1). A decrease in circulating omentin level is related to the occurrence of type 2 diabetes and metabolic syndrome (19). It was also demonstrated that a decrease in circulating omentin level independently correlated with an increased arterial stiffness and carotid plaque in type 2 diabetes (24).…”