Evaluation of the relationship between HbA1c level and retina choroidal thickness in patients with gestational diabetes mellitus

Kahveci, Bekir; Ekinci, Yıldız Dilbade

doi:10.5935/0004-2749.20220045

Cited by 3 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study conducted by Kahveci et al . [ 14 ] showed central foveal thickening in diabetic patients with HbA1c of more than 6%. A study by Jiang et al .…”

Section: Discussionmentioning

confidence: 99%

Comparative study to evaluate retinal changes using spectral-domain optical coherence tomography in diabetics without diabetic retinopathy

Harwal

Shashidhar

Hithashree

et al. 2023

Indian Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose: To elucidate changes in the neuro-sensory retina at the macula, using spectral-domain optical coherence tomography (SD-OCT) in type 2 diabetics without clinical signs of diabetic retinopathy, and compare with healthy subjects. Methods: This was a cross-sectional observational study, conducted at a tertiary eye institute from November 2018 to March 2020. Type 2 diabetics visiting the outpatient department with normal fundus (without any clinical signs of diabetic retinopathy) were taken as Group 1, and healthy subjects as Group 2. Both underwent recording of visual acuity, intraocular pressure (non-contact tonometry), slit-lamp anterior segment examination, fundus examination using an indirect ophthalmoscope, and macular SD-OCT. SPSS (Statistical Package for Social Sciences) version 20 [IBM SPSS statistics (IBM corp. Armonk, NY, USA released 2011)] was used to perform the statistical analysis of the data entered in the excel sheet. Results: Our study included 440 eyes of 220 subjects, divided equally into two groups. The mean age of patients with diabetes was 58.09 ± 9.42 years, and of controls 57.25 ± 8.91 years. The mean BCVA in group 1 and group 2 was 0.36 ± 0.37 and 0.21 ± 0.24 logMAR, respectively. SD-OCT showed thinning in all areas in group 1 compared to group 2, but statistically significant thinning was seen only in the central subfield ( P = 0.0001), temporal parafoveal ( P = 0.0001), temporal perifoveal ( P = 0.0005), and nasal perifoveal areas ( P = 0.023) in group 1. There was a significant inter-eye difference noted between the right and left eyes in nasal and inferior parafovea only in group 1 ( P = 0.03). No significant difference was noted between males and females. Conclusion: There was significant macular thinning in diabetics compared with controls, which denotes the occurrence of neuronal damage in these eyes before clinical evidence of diabetic retinopathy.

show abstract

“…A study conducted by Kahveci et al . [ 14 ] showed central foveal thickening in diabetic patients with HbA1c of more than 6%. A study by Jiang et al .…”

Section: Discussionmentioning

confidence: 99%

Comparative study to evaluate retinal changes using spectral-domain optical coherence tomography in diabetics without diabetic retinopathy

Harwal

Shashidhar

Hithashree

et al. 2023

Indian Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…Moreover, unlike acromegaly, the impact of DM on choroidal parameters, such as ChT, the choroidal vascular index (CVI), and DR progression have been shown to be more related to disease status and duration than to serum biomarker levels at a single time point. 21 , 22 We, therefore, evaluated the interaction and moderating effects of DM and acromegaly as categorical variables as well as serum biomarkers as continuous variables in different statistical models.…”

Section: Introductionmentioning

confidence: 99%

Blood Glucose Levels Moderate the Associations Between IGF-1 Levels and Choroidal Metrics in Patients With Diabetes With Acromegaly Without Diabetic Retinopathy

Zhang,

Wang,

Zhang

et al. 2024

Trans. Vis. Sci. Tech.

View full text Add to dashboard Cite

Purpose To examine the effects of serum growth hormone (GH) and insulin-like growth factor-1 (IGF-1) on choroidal structures with different blood glucose levels in patients with diabetes mellitus (DM) with acromegaly without diabetic retinopathy. Methods Eighty-eight eyes of 44 patients with acromegaly were divided into a nondiabetic group (23 patients, 46 eyes) and a diabetic group (21 patients, 42 eyes). Forty-four age- and sex-matched healthy controls and 21 patients with type 2 DM without diabetic retinopathy were also included. Linear regression models with a simple slope analysis were used to identify the correlation and interaction between endocrine parameters and choroidal thickness (ChT), total choroidal area (TCA), luminal area (LA), stromal area (SA), and choroidal vascular index (CVI). Results Our study revealed significant increases in the ChT, LA, SA, and TCA in patients with acromegaly compared with healthy controls, with no difference in the CVI. Comparatively, patients with DM with acromegaly had greater ChT than matched patients with type 2 DM, with no significant differences in other choroidal parameters. The enhancement of SA, LA and TCA caused by an acromegalic status disappeared in patients with diabetic status, whereas ChT and CVI were not affected by the interaction. In the diabetic acromegaly, higher IGF-1 ( P = 0.006) and GH levels ( P = 0.049), longer DM duration ( P = 0.007), lower blood glucose ( P = 0.001), and the interaction between GH and blood glucose were associated independently with thicker ChT. Higher GH levels ( P = 0.016, 0.004 and 0.007), longer DM duration ( P = 0.022, 0.013 and 0.013), lower blood glucose ( P = 0.034, 0.011 and 0.01), and the interaction of IGF-1 and blood glucose were associated independently with larger SA, LA, and TCA. As blood glucose levels increased, the positive correlation between serum GH level and ChT diminished, and became insignificant when blood glucose was more than 7.35 mM/L. The associations between serum IGF-1 levels and LA, SA, and TCA became increasingly negative, with LA, becoming significantly and negatively associated to the GH levels only when blood glucose levels were more than 8.59 mM/L. Conclusions Acromegaly-related choroidal enhancements diminish in the presence of DM. In diabetic acromegaly, blood glucose levels are linked negatively with changes in choroidal metrics and their association with GH and IGF-1. Translational Relevance We revealed the potential beneficial impacts of IGF-1 and GH on structural measures of the choroid in patients with DM at relatively well-controlled blood glucose level, which could provide a potential treatment target for diabetic retinopathy.

show abstract

Secular increase in the prevalence of gestational diabetes and its associated adverse pregnancy outcomes from 2014 to 2021 in Hebei province, China

Tian

Du²,

et al. 2022

Front. Endocrinol.

View full text Add to dashboard Cite

ObjectiveWe aimed to investigate the secular prevalence of gestational diabetes mellitus (GDM) and evaluate its adverse pregnancy outcomes among pregnant women in Hebei province, China.MethodsWe analyzed the data from the monitoring information management system for pregnant women in 22 hospitals of Hebei province, China. In this study, 366,212 individuals with singleton live births from 2014 to 2021 were included, of whom 25,995 were diagnosed with gestational diabetes. We described the incidence of common complications and further analyzed the clinical characteristics in GDM patients and the relationship between GDM and adverse pregnancy outcomes.ResultsThe top 3 pregnancy complications in Hebei province are anemia, gestational hypertension, and GDM. The average incidence of GDM was 7.10% (25,995/366,212). The incidence rate of GDM significantly increased from 2014 to 2021 (χ2trend = 7,140.663, P < 0.001). The top 3 regions with GDM incidence were Baoding (16.60%), Shijiazhuang (8.00%), and Tangshan (3.80%). The incidence of GDM in urban pregnant women (10.6%) is higher than that in rural areas (3.7%).The difference between the GDM and Non-GDM groups was statistically significant in terms of maternal age, gravidity, parity, education level, and incidence of pregnancy complications (gestational hypertension, heart diseases, and anemia) (P < 0.05). GDM individuals were at significantly increased risk of most assessed adverse pregnancy outcomes, including premature delivery, Cesarean delivery, uterine inertia, neonatal intensive care unit (NICU) admission, Apgar (activity-pulse-grimace-appearance-respiration) score at 1 min, and macrosomia (P < 0.05). The multivariate logistic regression analysis showed that GDM was an independent risk factor in terms of premature birth, Cesarean delivery, uterine inertia, placental abruption, NICU admission, and macrosomia.ConclusionThe risk of adverse pregnancy outcome in pregnant women with GDM is significantly increased. In order to reduce the occurrence of adverse pregnancy outcomes, effective interventions are needed.

show abstract

Evaluation of the relationship between HbA1c level and retina choroidal thickness in patients with gestational diabetes mellitus

Cited by 3 publications

References 12 publications

Comparative study to evaluate retinal changes using spectral-domain optical coherence tomography in diabetics without diabetic retinopathy

Comparative study to evaluate retinal changes using spectral-domain optical coherence tomography in diabetics without diabetic retinopathy

Blood Glucose Levels Moderate the Associations Between IGF-1 Levels and Choroidal Metrics in Patients With Diabetes With Acromegaly Without Diabetic Retinopathy

Secular increase in the prevalence of gestational diabetes and its associated adverse pregnancy outcomes from 2014 to 2021 in Hebei province, China

Contact Info

Product

Resources

About