Evaluation of the Relationship Between the Changes in the Corneal Biomechanical Properties and Changes in the Anterior Segment OCT Parameters Following Customized Corneal Cross-Linking

Nishida, Tomoya; Kojima, Takashi; Kataoka, Tetsuro; Isogai, Naoki; Yoshida, Yoko; Nakamura, Tomoaki

doi:10.2147/opth.s361836

Cited by 2 publications

(1 citation statement)

References 42 publications

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“…A previous study revealed that the SSI was not significantly different between eyes with mild keratoconus and normal eyes, and the AUROC was 0.642 for detecting keratoconus ( Herber et al, 2022 ), which is similar to that in our study ( Supplementary Tables S1, S2 ), suggesting that the SSI alone was not suitable for screening keratoconus. However, the SSI was proven to decrease significantly during the reduction of corneal stiffness in the progression of keratoconus ( Padmanabhan et al, 2022 ) and increased after corneal cross-linking ( Nishida et al, 2022 ), demonstrating that the SSI may be more suitable for monitoring the progression and treatment efficacy in keratoconus, however, its application in screening keratoconus still needs to be further explored.…”

Section: Discussionmentioning

confidence: 99%

Comparison of bilateral differential characteristics of corneal biomechanics between keratoconus and normal eyes

Xian,

Zhao,

Sun

et al. 2023

Front. Bioeng. Biotechnol.

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Purpose: To compare bilateral differences in corneal biomechanics between keratoconus and normal eyes.Methods: In this case-control study, 346 eyes of 173 patients (aged 22.1 ± 6.1 years) with keratoconus (KC group) and 378 eyes of 189 patients (aged 26.7 ± 5.6 years) with ametropia (control group) were enrolled. Corneal tomography and biomechanical properties were examined using Pentacam HR and Corvis ST, respectively. The corneal biomechanical parameters were compared between eyes with forme fruste keratoconus (FFKC) and normal eyes. Bilateral differences in corneal biomechanical parameters were compared between the KC and control groups. Receiver operating characteristic (ROC) analysis was used to assess discriminative efficacies.Results: The areas under the ROC curves (AUROCs) of stiffness parameter at the first applanation (SP-A1) and Tomographic and Biomechanical Index (TBI) for identifying FFKC were 0.641 and 0.694, respectively. The bilateral differential values of major corneal biomechanical parameters were significantly increased in the KC group (all p < 0.05), except for the Corvis Biomechanical Index (CBI). The AUROCs of the bilateral differential values of the deformation amplitude ratio at 2 mm (ΔDAR2), Integrated Radius (ΔIR), SP-A1 (ΔSP-A1), and the maximum inverse concave radius (ΔMax ICR) for discriminating keratoconus were 0.889, 0.884, 0.826, and 0.805, respectively. The Logistic Regression Model-1 (comprising of ΔDAR2, ΔIR, and age) and the Logistic Regression Model-2 (comprising of ΔIR, ΔARTh, ΔBAD-D, and age) had AUROCs of 0.922 and 0.998, respectively, for discriminating keratoconus.Conclusion: The bilateral asymmetry of corneal biomechanics was significantly increased in keratoconus compared with normal eyes, which may be helpful for the early detection of keratoconus.

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Section: Discussionmentioning

confidence: 99%