Evaluation of the relationship between interleukin‐1 gene cluster polymorphisms and early implant failure in non‐smoking patients

Campos, Maria Isabela Guimarães; Santos, Maria Cristina Leme Godoy dos; Trevilatto, Paula Cristina; Scarel‐Caminaga, Raquel Mantuaneli; Bezerra, Fábio; Line, Sérgio Roberto Peres

doi:10.1111/j.1600-0501.2004.01091.x

Cited by 36 publications

(61 citation statements)

References 50 publications

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“…Regarding ethnic status, Caucasians were prevalent compared with Afro-Americans/mulatto individuals; however, no further analysis was performed based on such classification in view of the high genetic miscegenation of the Brazilian population (40). The frequencies of IL-1␤(3954) genotypes and alleles were found to be similar in the CP and C groups (Table 3) and were also found to be similar to those reported for the Brazilian population in previous studies (4,34,56).…”

Section: Il-1␤(3954c/t) Snp Frequency Analysis In C and Cp Groupssupporting

confidence: 64%

An Interleukin-1β (IL-1β) Single-Nucleotide Polymorphism at Position 3954 and Red Complex Periodontopathogens Independently and Additively Modulate the Levels of IL-1β in Diseased Periodontal Tissues

Ferreira¹,

Trombone

Repeke³

et al. 2008

Infect Immun

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Section: Il-1␤(3954c/t) Snp Frequency Analysis In C and Cp Groupssupporting

confidence: 64%

An Interleukin-1β (IL-1β) Single-Nucleotide Polymorphism at Position 3954 and Red Complex Periodontopathogens Independently and Additively Modulate the Levels of IL-1β in Diseased Periodontal Tissues

Ferreira¹,

Trombone

Repeke³

et al. 2008

Infect Immun

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“…(Table 1) or between survivors and nonsurvivors. Allele frequencies of all polymorphisms within the control group were similar to previously published results (9,11,12 ).…”

supporting

confidence: 76%

Polymorphisms in the Interleukin-1 Gene Cluster in Children and Young Adults with Systemic Meningococcemia

Endler

Marculescu²,

Starkl³

et al. 2006

Clinical Chemistry

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Background: An association has been described between mortality in children with meningococcal disease and functional polymorphisms in the interleukin-1 (IL1) cluster. We undertook a multicenter study to evaluate associations of these polymorphisms in a Central European population. Patients and Methods: The study involved 95 Middle European pediatric hospitals. We collected blood samples from, and clinical information about, 285 previously healthy children with meningococcal infection. We used a newly developed multiplexed mutagenic separated PCR assay to analyze 6 polymorphisms within the IL1 cluster: IL1A (؊889)C/T, IL1A (؉4845)G/T, IL1B (؊511)C/T, IL1B (؊31)C/T, IL1B (؉3954), and IL1RA (؉2018)C/T. We studied the same polymorphisms in a comparison group of 481 healthy newborns. Results: Genotype frequencies between patients and the comparison group differed significantly only for the IL1RA (؉2018)C/T variant: The CC genotype was more frequent in patients (11%) than in healthy controls (5%; P ‫؍‬ 0.008). In the patient group, the C allele was significantly more prevalent (67%) in nonsurvivors than in survivors (42%; P ‫؍‬ 0.02). Conclusion: The IL1RA (؉2018)C/T polymorphism is associated with the risk of meningococcal disease and with its outcome.

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“…Nevertheless, no significant associations between the distributio of the IL-1A and IL-1B genotypes and periodontal status were found. In contrast to these findings, most of the studies showed an elevated frequency of heterozygous (1.2) and a markedly decreased prevalence of homozygous (2.2) for both IL-1 genes [5,7,15,18,20]. Using a regression model, only age (P ¼ 0.015), bleeding on probing (P < 0.001) and HIV infection (P ¼ 0.005) had an effect on the outcome of chronic periodontitis.…”

mentioning

confidence: 77%

IL-1 gene polymorphism and periodontal status of HIV Brazilians on highly active antiretroviral therapy

Gonçalves¹,

Ferreira

Souza

et al. 2006

Aids

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A genotype in the IL-1 gene cluster is associated with an increased risk of periodontitis. We investigated whether polymorphisms in the IL-1A +4845 and IL-1B +3954 loci affect the periodontal status of HIV-infected Brazilians on HAART. HIV-positive and HIV-negative subjects with periodontitis were genotyped for IL-1 by polymerase chain reaction and restriction enzyme digestion. Only 11.4% of patients were genotype positive. No associations between genotype positivity and HIV infection or periodontal status were found in this population.

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Evaluation of the relationship between interleukin‐1 gene cluster polymorphisms and early implant failure in non‐smoking patients

Abstract: This study suggests that polymorphisms in the interleukin-1 gene cluster are not associated with early implant failure in a non-smoking Brazilian population.

Cited by 36 publications

References 50 publications

An Interleukin-1β (IL-1β) Single-Nucleotide Polymorphism at Position 3954 and Red Complex Periodontopathogens Independently and Additively Modulate the Levels of IL-1β in Diseased Periodontal Tissues

An Interleukin-1β (IL-1β) Single-Nucleotide Polymorphism at Position 3954 and Red Complex Periodontopathogens Independently and Additively Modulate the Levels of IL-1β in Diseased Periodontal Tissues

Polymorphisms in the Interleukin-1 Gene Cluster in Children and Young Adults with Systemic Meningococcemia

IL-1 gene polymorphism and periodontal status of HIV Brazilians on highly active antiretroviral therapy

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