Evaluation of the relationship between serum carnitine levels and intradialytic complications in children with kidney failure

Bazargani, Behnaz; Mojtahedi, Sayed Yousef; Fahimi, Daryoosh; Askarian, Fahimeh; Moghtaderi, Mastaneh; Abbasi, Arash; Samimi, M.M.; Koohsorkhi, Maryam Bakhtiari

doi:10.1007/s00467-022-05449-w

Cited by 4 publications

(3 citation statements)

References 18 publications

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“…An examination of the causal relationship between these five key metabolites and the preventive effects of aerobic exercise on obesity-related renal injury is warranted in the future. In addition, 3-hydroxyglutaric acid is a known metabolite of the kidney [ 25 , 26 ] ( Table 2 , metabolites 22–24), which we found to be affected by HFD and further changed in the same direction by exercise. We speculated that these may be metabolites of a stress response to obesity and aerobic challenge and should be further investigated.…”

Section: Discussionmentioning

confidence: 96%

Aerobic exercise attenuates high-fat diet–induced renal injury through kidney metabolite modulation in mice

Xiong,

Luan,

Yuan

et al. 2024

Renal Failure

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Purpose To investigate the preventive effect of aerobic exercise on renal damage caused by obesity. Methods The mice in the Control (Con) and Control + Exercise (Con + Ex) groups received a standard chow diet for the 21-week duration of the study, while the High-fat diet (HFD) group and High-fat diet + Exercise (HFD + Ex) group were fed an HFD. Mice were acclimated to the laboratory for 1 week, given 12 weeks of being on their respective diets, and then the Con + Ex and HFD + Ex groups were subjected to moderate intensity aerobic treadmill running 45 min/day, 5 days/week for 8 weeks. Results We found that HFD-induced obesity mainly impacts kidney glycerin phospholipids, glycerides, and fatty acyls, and aerobic exercise mainly impacts kidney glycerides, amino acids and organic acids as well as their derivatives. We identified 18 metabolites with significantly altered levels that appear to be involved in aerobic exercise mediated prevention of HFD-induced obesity and renal damage, half of which were amino acids and organic acids and their derivatives. Conclusion Aerobic exercise rewires kidney metabolites to reduce high-fat diet-induced obesity and renal injury.

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Section: Discussionmentioning

confidence: 96%

Aerobic exercise attenuates high-fat diet–induced renal injury through kidney metabolite modulation in mice

Xiong,

Luan,

Yuan

et al. 2024

Renal Failure

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“…Carnitine, a critical nutrient in beta oxidation, has been found to be deficient in a variety of patient groups, including but not limited to neonates, those receiving PN, those with malnutrition, those receiving CRRT, and those receiving frequent HD. [47][48][49] Carnitine deficiency has been reported to lead to cardiac dysfunction, erythropoietin-resistant anemia, and difficulty metabolizing fatty acids. In a small retrospective study in children receiving CRRT, those who were deficient and not supplemented with carnitine experienced worse myocardial strain.…”

Section: Carnitinementioning

confidence: 99%

Nutrition for critically ill children and neonates requiring dialysis: Application of clinical practice recommendations

Wong Vega,

Vuong,

Chmielewski

et al. 2023

Nut in Clin Prac

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Approximately 30% of all children and neonates admitted to the intensive care unit (ICU) experience acute kidney injury (AKI). Children with AKI are largely poorly fed and experience high rates of malnutrition. Nutrition prescription and provision are exceptionally challenging for critically ill neonates, infants, and children with AKI given the dynamic nature of AKI and its respective treatment modalities. Managing the nutrition prescription of critically ill neonates, infants, and children with AKI requires nutrition support clinicians to have a high‐level understanding of the various treatment modalities for AKI, which can affect the patient's protein, fluid, electrolyte, and mineral needs. Accurate and timely nutrition assessment in critically ill neonates and children with AKI can be flawed owing to difficulty obtaining accurate anthropometric parameters. Recently, the Pediatric Renal Nutrition Taskforce introduced clinical practice recommendations for the nutrition management of children with AKI. In this review, we will discuss the practical implications of these recent guidelines and work to bridge the knowledge and practice gaps for pediatric and neonatal nutrition support clinicians providing nutrition therapy for patients with AKI in the ICU. We also appraise special nutrition‐related considerations for neonates with AKI given newer available renal replacement treatment modalities.

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“…Comorbid diseases such as diabetes mellitus, hypertension, and heart disease are some of the causes of intradialytic complications [8]. Other causes associated with intradialytic complications are Quick Blood [9], length of time undergoing hemodialysis [10], vascular access during dialysis [11], hemodialysis counts in 1 week [12], and creatinine laboratory results before dialysis [13]. A higher serum creatinine yield is associated with an increase in symptoms such as seizures, muscle cramps, and intradialysis can be minimized, the quality of life of patients undergoing hemodialysis can be improved [15].…”

Section: Intradialytic Complications Duringmentioning

confidence: 99%

Contributing Factors to Intradialytic Complications in Hemodialysis Patients

Arsa,

Rahmawati

2023

Babali Nurs. Res.

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Introductioin : Intradialytic complications are still being debated among health workers in the Hemodialysis Unit in Hospitals, many factors can cause patients to experience complications during dialysis. This study aims to identify the factors that contribute to the incidence of intradialytic complications in order to minimize the incidence of complications. Methode : This study used a research design in the form of analytic descriptive with cross-sectional. The sampling technique was a consecutive sampling of 120 patients. The chi-square statistical test aims to examine differences in proportions. If the results of the bivariate test have p < 0.25, then these variables can be included in the multivariate model using multiple logistic regression analysis. Result : Candidate selection results, Hb (0,014), Fluid Compliance (0,221), Venous Access (0,236), IDWG (0,023), and Comorbid (0,006) have a p value less than 0.25. In the multivariate test obtained Comorbid (0,007; OR:2.361 ), IDWG (0,049;OR:-1,894), and Hb (0,047;OR: 0,922), it can be concluded that these three factors have a significant influence on the occurrence of intradialytic complications.The proportion of intradialytic problems that can be described by 5 variables, namely venous access, comorbidities, IDWG, HB, and adherence, is 24%, with the remaining 18% explained by other factors. Conclusion : Comorbid, interdialytic weight gain, and hemoglobin goal accomplishment all have a significant role in the occurrence of intradialytic complication. The findings of this study can be utilized to raise awareness of intradialytic consequences. This vulnerable population need effective management to manage the problems they are experiencing.

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Evaluation of the relationship between serum carnitine levels and intradialytic complications in children with kidney failure

Cited by 4 publications

References 18 publications

Aerobic exercise attenuates high-fat diet–induced renal injury through kidney metabolite modulation in mice

Aerobic exercise attenuates high-fat diet–induced renal injury through kidney metabolite modulation in mice

Nutrition for critically ill children and neonates requiring dialysis: Application of clinical practice recommendations

Contributing Factors to Intradialytic Complications in Hemodialysis Patients

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