Evaluation of the Reactivity of Sera from Patients with Systemic Lupus Erythematosus Against the Human MCP1

Bronze-da-Rocha, Elsa; Nóvoa, Ana; Teixeira, Natércia; Vasconcelos, Carlos; Cerveira, Conceição; Melo, João Castro e; Carvalho, Manuel Cirne

doi:10.1007/s10875-012-9665-4

Cited by 6 publications

(2 citation statements)

References 19 publications

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“…Histological features of LN include increased numbers of mesangial cells, overproduction of extracellular matrix, and infiltration of inflammatory cells, leading to the development of sclerosis and fibrosis [ 2 ]. Emerging evidence shows that a large number of cytokines and chemokines were involved in the pathogenesis of LN [ 3 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

Let-7 miRNAs Modulate the Activation of NF-κB by Targeting TNFAIP3 and Are Involved in the Pathogenesis of Lupus Nephritis

Zhu

Xie

et al. 2015

PLoS ONE

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TNFAIP3 is a ubiquitin-editing enzyme that negatively regulates multiple NF-κB signaling pathways and dysregulation of TNFAIP3 is related to systemic lupus erythematosus (SLE). Although there exists evidence indicating that microRNAs (miRNAs) modulate the expression of TNFAIP3, whether and how miRNAs regulate TNFAIP3 and contribute to lupus nephritis (LN) is still not well understood. In this study, we screened eleven selected miRNAs that potentially regulated TNFAIP3 expression by dual luciferase assay and found that Let-7 miRNAs repressed TNFAIP3 expression by targeting the 3′UTR of TNFAIP3 mRNA. Overexpression of Let-7 miRNAs led to increased phosphorylation and sustained degradation of IκBα and enhanced phosphorylation of p65 following TNFα stimulation and promoted SeV-induced production of cytokines in HEK293T cells. In addition, the expression of Let-7 miRNAs was significantly up-regulated, and TNFAIP3 level was remarkably down-regulated in samples from LN patients compared control samples. Our findings have uncovered Let-7-TNFAIP3-NF-κB pathway that is involved in LN and thus provided a potential target for therapeutic intervention.

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Section: Introductionmentioning

confidence: 99%

Let-7 miRNAs Modulate the Activation of NF-κB by Targeting TNFAIP3 and Are Involved in the Pathogenesis of Lupus Nephritis

Zhu

Xie

et al. 2015

PLoS ONE

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“…Furthermore, one finding is that the extract of CM has anti-inflammatory effects through the inhibition of COX-2 expression by suppressing the phosphorylation of I-κBα and the activation of NF-κB [54]. CCL2, known as monocyte chemoattractant protein-1(MCP-1), a key mediator in inflammatory processes, has a diagnostic value as a specific marker for SLE diagnosis [55]. e component of CM, terpene glycoside, could reduce the proinflammatory molecules IL-6 and MCP-1 expressions [56].…”

Section: Discussionmentioning

confidence: 99%

Potential Molecular Mechanisms of Zhibai Dihuang Wan in Systemic Lupus Erythematosus Based on Network Biology

Yang

Xie

Zhong

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Systemic lupus erythematosus (SLE) is a refractory autoimmune disease. Zhibai Dihuang Wan (ZDW) has frequently been used for treating SLE in China and been proved to have a prominent role in decreasing SLE patients’ morality rate. However, the active substances in ZDW and the molecular mechanisms of ZDW in SLE remain unclear. This study identified the bioactive compounds and delineated the molecular targets and potential pathways of ZDW by using a network biology approach. First, we collected putative targets of ZDW based on TCMSP, GeneCards, and STITCH databases and built a network containing the interactions between the putative targets of ZDW and known therapeutic targets of SLE. Then, the key hubs were imported to DAVID Bioinformatics Resources 6.7 to perform gene ontology biological process (GOBP) and pathway enrichment analysis. A total of 95 nodes including 73 putative targets of ZDW were determined as major hubs in terms of their node degree. The results of GOBP and pathway enrichment analysis indicated that putative targets of ZDW mostly were involved in various pathways associated with inflammatory response and apoptosis. More importantly, eleven putative targets of ZDW (CASP3, BCL2, BAX, CYCS, NFKB1, NFKBIA, IL-6, IL-1β, PTGS2, CCL2, and TNF-α) were recognized as active factors involved in the main biological functions of treatment, implying the underlying mechanisms of ZDW acting on SLE. This study provides novel insights into the mechanisms of ZDW in SLE, from the molecular level to the pathway level.

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Chemokine and Adhesion Molecule Profiles in Aqueous Humor of Clinically Quiescent Uveitic Cataracts

Pei

Liu

Zhao

et al. 2018

Current Eye Research

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Evaluation of the Reactivity of Sera from Patients with Systemic Lupus Erythematosus Against the Human MCP1

Cited by 6 publications

References 19 publications

Let-7 miRNAs Modulate the Activation of NF-κB by Targeting TNFAIP3 and Are Involved in the Pathogenesis of Lupus Nephritis

Let-7 miRNAs Modulate the Activation of NF-κB by Targeting TNFAIP3 and Are Involved in the Pathogenesis of Lupus Nephritis

Potential Molecular Mechanisms of Zhibai Dihuang Wan in Systemic Lupus Erythematosus Based on Network Biology

Chemokine and Adhesion Molecule Profiles in Aqueous Humor of Clinically Quiescent Uveitic Cataracts

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