Evaluation of the rapid Idylla IDH1-2 mutation assay in FFPE glioma samples
James P. Solomon,
Carlos Munoz-Zuluaga,
Cheyanne Slocum
et al.
Abstract:IDH1 and IDH2 mutational status is a critical biomarker with diagnostic, prognostic, and treatment implications in glioma. Although IDH1 p.R132H-specific immunohistochemistry is available, it is unable to identify other mutations in IDH1/2. Next-generation sequencing can accurately determine IDH1/2 mutational status but suffers from long turnaround time when urgent treatment planning and initiation is medically necessary. The Idylla assay can detect IDH1/2 mutational status from unstained formalin-fixed paraff… Show more
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