Evaluation Of The Quercetin Semisynthetic Derivatives Interaction With Breast Cancer Resistance Protein

Abstract

Breast cancer resistance protein (BCRP, ABCG2) is one of the ATP binding cassette (ABC) transporter proteins which involved in multi-drug resistance of cancer therapy. BCRP is expressed in various types of human cancer and inhibiting can be a solution to overcome multidrug resistance. Significant effort has been devoted to develop treatment strategies to overcome BCRP-mediated resistance. In addition, BCRP is expressed also in many normal tissues and plays an important role in drug absorption, distribution, and elimination. In order to design an effective cancer treatment strategy, a lot of flavones and their derivatives are used as anticancer drug compounds. One of the most promising flavonols is quercetin and quercetin semisynthetic derivatives which can inhibit the expression of BCRP.

O‐Glycosidequercetin derivatives: Biological activities, mechanisms of action, and structure–activity relationship for drug design, a review

“…Quercetin is found in numerous fruits, vegetables, Chinese herbal medicines, and several drinks like coffee, tea, red wine, fruit juice (Cheng et al, 2019;Dymarska, Janeczko, & Kostrzewa-Susłow, 2018), and many plants (Das et al, 2020;Poljuha et al, 2017). Quercetin has different biological activities (Table 1) ) such as anticancer (Hanikoglu et al, 2020;Manukyan, 2019;Manukyan & Hovhannisyan, 2020), antioxidant (Houngue et al, 2017;Li et al, 2018;, antibacterial (Adamczak, Ożarowski, & Karpi nski, 2020;Pal & Tripathi, 2020;Yadav, Mehrotra, Bhartiya, Singh, & Dutta, 2020), antiinflammatory (Endale et al, 2013;Kooshyar et al, 2017;Qin et al, 2017), anti-Alzheimer (da Silva et al, 2019; Y. Qi, Yi, et al, 2020;, antifungal (Al-Huqail et al, 2019;Kwun & Lee, 2020;Petrescu, Paunescu, & Ilia, 2019), antiviral (Colunga Biancatelli, Berrill, Catravas, & Marik, 2020;M.…”

“…Quercetin is found in numerous fruits, vegetables, Chinese herbal medicines, and several drinks like coffee, tea, red wine, fruit juice (Cheng et al, 2019; Dymarska, Janeczko, & Kostrzewa‐Susłow, 2018), and many plants (Das et al, 2020; Poljuha et al, 2017). Quercetin has different biological activities (Table 1) (Batiha, Beshbishy, et al, 2020) such as anticancer (Hanikoglu et al, 2020; Manukyan, 2019; Manukyan & Hovhannisyan, 2020), antioxidant (Houngue et al, 2017; Li et al, 2018; J. Liu et al, 2018), antibacterial (Adamczak, Ożarowski, & Karpiński, 2020; Pal & Tripathi, 2020; Yadav, Mehrotra, Bhartiya, Singh, & Dutta, 2020), antiinflammatory (Endale et al, 2013; Kooshyar et al, 2017; Qin et al, 2017), anti‐Alzheimer (da Silva et al, 2019; Y. Qi, Yi, et al, 2020; P. Qi, Li, et al, 2020), antifungal (Al‐Huqail et al, 2019; Kwun & Lee, 2020; Petrescu, Paunescu, & Ilia, 2019), antiviral (Colunga Biancatelli, Berrill, Catravas, & Marik, 2020; M. Liu et al, 2020; Sekiou, Bouziane, Bouslama, & Djemel, 2020), antithalassemia or iron chelation (Diamantis et al, 2018; Lesjak, Balesaria, Skinner, Debnam, & Srai, 2019; Vlachodimitropoulou, Sharp, & Naftalin, 2011), antiobesity (Carrasco‐Pozo, Cires, & Gotteland, 2019; Kim et al, 2015; Nasri et al, 2019), antidiabetic (Ali et al, 2020; Hassanien, Saad, & Radwan, 2020; Yao et al, 2019), antihypertension (Brüll et al, 2017; Elbarbry, Abdelkawy, Moshirian, & Abdel‐Megied, 2020), protection of cardiovascular (Jagtap et al, 2009; Jing et al, 2016; Zhang, Zhang, & Wang, 2020), anti‐Parkinson (Zbarsky et al, 2005), and antiphospholipase A2 (PLA2) activities (Alves et al, 2018; Costa et al, 2013; Da Silva, Calgarotto, Chaar, & Marangoni, 2008; Nworu & Akah, 2015...…”