Evaluation of the Quercetin Semisynthetic Derivatives Interaction with ABCG2 and Cyclooxygenase-2

O‐Glycosidequercetin derivatives: Biological activities, mechanisms of action, and structure–activity relationship for drug design, a review

“…Quercetin is found in numerous fruits, vegetables, Chinese herbal medicines, and several drinks like coffee, tea, red wine, fruit juice (Cheng et al, 2019;Dymarska, Janeczko, & Kostrzewa-Susłow, 2018), and many plants (Das et al, 2020;Poljuha et al, 2017). Quercetin has different biological activities (Table 1) ) such as anticancer (Hanikoglu et al, 2020;Manukyan, 2019;Manukyan & Hovhannisyan, 2020), antioxidant (Houngue et al, 2017;Li et al, 2018;, antibacterial (Adamczak, Ożarowski, & Karpi nski, 2020;Pal & Tripathi, 2020;Yadav, Mehrotra, Bhartiya, Singh, & Dutta, 2020), antiinflammatory (Endale et al, 2013;Kooshyar et al, 2017;Qin et al, 2017), anti-Alzheimer (da Silva et al, 2019; Y. Qi, Yi, et al, 2020;, antifungal (Al-Huqail et al, 2019;Kwun & Lee, 2020;Petrescu, Paunescu, & Ilia, 2019), antiviral (Colunga Biancatelli, Berrill, Catravas, & Marik, 2020;M.…”

“…Quercetin is found in numerous fruits, vegetables, Chinese herbal medicines, and several drinks like coffee, tea, red wine, fruit juice (Cheng et al, 2019; Dymarska, Janeczko, & Kostrzewa‐Susłow, 2018), and many plants (Das et al, 2020; Poljuha et al, 2017). Quercetin has different biological activities (Table 1) (Batiha, Beshbishy, et al, 2020) such as anticancer (Hanikoglu et al, 2020; Manukyan, 2019; Manukyan & Hovhannisyan, 2020), antioxidant (Houngue et al, 2017; Li et al, 2018; J. Liu et al, 2018), antibacterial (Adamczak, Ożarowski, & Karpiński, 2020; Pal & Tripathi, 2020; Yadav, Mehrotra, Bhartiya, Singh, & Dutta, 2020), antiinflammatory (Endale et al, 2013; Kooshyar et al, 2017; Qin et al, 2017), anti‐Alzheimer (da Silva et al, 2019; Y. Qi, Yi, et al, 2020; P. Qi, Li, et al, 2020), antifungal (Al‐Huqail et al, 2019; Kwun & Lee, 2020; Petrescu, Paunescu, & Ilia, 2019), antiviral (Colunga Biancatelli, Berrill, Catravas, & Marik, 2020; M. Liu et al, 2020; Sekiou, Bouziane, Bouslama, & Djemel, 2020), antithalassemia or iron chelation (Diamantis et al, 2018; Lesjak, Balesaria, Skinner, Debnam, & Srai, 2019; Vlachodimitropoulou, Sharp, & Naftalin, 2011), antiobesity (Carrasco‐Pozo, Cires, & Gotteland, 2019; Kim et al, 2015; Nasri et al, 2019), antidiabetic (Ali et al, 2020; Hassanien, Saad, & Radwan, 2020; Yao et al, 2019), antihypertension (Brüll et al, 2017; Elbarbry, Abdelkawy, Moshirian, & Abdel‐Megied, 2020), protection of cardiovascular (Jagtap et al, 2009; Jing et al, 2016; Zhang, Zhang, & Wang, 2020), anti‐Parkinson (Zbarsky et al, 2005), and antiphospholipase A2 (PLA2) activities (Alves et al, 2018; Costa et al, 2013; Da Silva, Calgarotto, Chaar, & Marangoni, 2008; Nworu & Akah, 2015...…”