Evaluation of the Protein C Global Assay During Normal Pregnancy and After Assisted Reproduction

Younis, Johnny S.; Shukha, Mervatte; Ben‐Ami, Moshe; Izhaki, Ido; Blumenfeld, Z.; Brenner, Benjamin; Sarig, Galit

doi:10.1097/aog.0b013e3181db67f3

Cited by 9 publications

(13 citation statements)

References 22 publications

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“…As well, abnormal ProC Global assay level rate is significantly higher in infertile women as compared to fertile controls. These results corroborates with our findings in a previous study examining ProC Global assay 6 weeks or later following delivery [11]. Our present study strengthens the results of our previous publication [11] and totally eliminates any hormonal or pregnancy related explanations for the difference encountered in ProC global assay level results between infertile women and fertile controls.…”

Section: Discussionsupporting

confidence: 83%

“…These results corroborates with our findings in a previous study examining ProC Global assay 6 weeks or later following delivery [11]. Our present study strengthens the results of our previous publication [11] and totally eliminates any hormonal or pregnancy related explanations for the difference encountered in ProC global assay level results between infertile women and fertile controls. These results support the idea that infertile women may be unique in their Protein C anticoagulation pathway characteristics.…”

Section: Discussionsupporting

confidence: 83%

“…In a previous prospective controlled study examining Protein C (ProC) Global assay in ART singleton pregnancies compared to naturally conceived pregnancies, our group has shown that ProC Global decrease gradually during pregnancy in both groups [11]. These findings were corroborated later by another group showing decreasing ProC Global assay levels in healthy women during pregnancy [12].…”

Section: Introductionsupporting

confidence: 72%

“…In our study, the decrease in ProC Global was found to be significantly more pronounced in the ART group as compared to the healthy controls. Interestingly, when both groups were compared 6 weeks or more following delivery, ProC Global was found to be significantly lower in the ART group as compared to controls [11], suggesting that infertile women before ART could be a priori distinct from fertile healthy women conceiving spontaneously.…”

Section: Introductionmentioning

confidence: 99%

“…Since our previous study, was performed in pregnant women and in the postpartum period [11], our intention in this study was to gain insight into the relation between ProC Global assay an infertile women eligible for ART treatment before starting therapy and prior to pregnancy achievement. By this way any hormonal treatment or pregnancy related affect on ProC Global assay would be eliminated.…”

Section: Introductionmentioning

confidence: 99%

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Reduced protein C Global assay level in infertile women prior to IVF-ET treatment

Younis

Ben‐Ami

Izhaki

et al. 2013

J Assist Reprod Genet

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Purpose In the last few years more robust evidence is emerging to point out at an increased rate of prematurity and low birth weight in singleton pregnancies following ART. Whether this increased rate is related to ART practice or to infertility per se, is still an open question. Our aim in this study was to explore this question by evaluating Protein C (ProC) Global assay in infertile women before ART treatment. Methods A cohort of 95 unselected and consecutive infertile women, eligible for ART, was prospectively recruited for the study. The control group included 77 matched healthy fertile women with a history of spontaneous conceptions. Pro C Global assay was evaluated in both groups. A full thrombophilic work-up was performed in the study group.Results ProC Global assay level was found to be significantly lower in the study as compared to the control group, corresponding to 0.78 ± 0.16 and 0.88 ± 0.16, respectively (P <0.01). As well, abnormal ProC Global assay level of ≤0.8 was significantly higher in the study as compared to control group corresponding to 53 % and 29 %, respectively. ProC Global assay level was significantly lower in women within the study group found to have APCR, factor V Leiden and high factor VIII level, any thrombophilia or combined thrombophilia when compared to women without these thrombophilic risk factors. Conclusions Reduced ProC Global assay level is encountered in infertile women prior to ART treatment. This finding may suggest a unique anticoagulation Protein C pathway in infertile as compared to fertile women. Further studies are encouraged to explore this finding.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 83%