Evaluation of the protective effects of Schisandra chinensis on Phase I drug metabolism using a CCl4 intoxication model

Zhu, Min; Lin, Kevin; Yeung, Raymond Y. T.; Li, R.C.

doi:10.1016/s0378-8741(98)00210-4

Cited by 77 publications

(38 citation statements)

References 6 publications

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“…Chiu et al (2002) reported that a lignan-enriched extract of Schisandra Chinensis has a dose dependent protection against CCl 4 hepatotoxicity. In addition, Zhu et al (1999Zhu et al ( , 2000 reported that SC exhibited strong protective effect on phase I oxidative metabolism in the liver damaged by CCl 4 , suggesting SC to be a promising agent for the improvement of phase I oxidative metabolism in the liver damaged by CCl 4 . The above studies from other animals are agreement with the present study.…”

Section: The Effect Of Scesc On Antioxidant Enzyme In Serum and Tissumentioning

confidence: 99%

Influence of Supercritical CO<sub>2</sub> Extraction of Schisandra Chinensis on Antioxidant Status, Carcass and Meat Quality of AA Broilers

et al. 2013

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The experiment was conducted to investigate the effect of dietary supplementation with different level of supercritical CO 2 extraction of Schisandra Chinensis (SCESC) (0.1%, 0.2%, and 0.4%) on antioxidant status and meat quality of broilers. The results showed that the total superoxide dismutase (T-SOD) activity in heart and liver was increased significantly by supplementing with SCESC in the diet of birds, the malonaldehyde (MDA) concentration in heart of birds was lower in the SCESC group than the control, and the glutathion reductase (GR) activity in liver and kidney of the birds was increased significantly. There was a significant reduction of the abdominal fat in the experimental group. The drip loss of breast meat was significantly decreased through supplementing with SCESC in the diet of birds. The pH was higher in the 0.1% SCESC group than the control. The shear force of breast meat from broilers was decreased by 0.2% SCESC supplementation. Compared to the control, the content of crude fat of breast meat from broilers was increased significantly. At the same time, diets supplemented with 0.2% SCESC increased the crude protein content of breast meats. Furthermore, diets supplemented with 0.4% SCESC had an increased Inosinic Acid (IMP) content significantly. On the basis of these observations, we concluded that diets supplemented with SCESC improved antioxidant enzyme activity of tissues and improved meat tenderness and nutritional value of breast and thigh meat.

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Section: The Effect Of Scesc On Antioxidant Enzyme In Serum and Tissumentioning

confidence: 99%

Influence of Supercritical CO<sub>2</sub> Extraction of Schisandra Chinensis on Antioxidant Status, Carcass and Meat Quality of AA Broilers

et al. 2013

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“…It has been reported that SF has various pharmacological activities, including antihepatotoxic [12,27], anti-inflammatory [14], anticarcinogenic [19], antioxidant, and detoxificant effects [12,16]. SF contains various active compounds, including essential oils, organic acids, tannins, anthocyanins and lignans [11].…”

Section: Introductionmentioning

confidence: 99%

Schisandra fructus extract ameliorates doxorubicin-induce cytotoxicity in cardiomyocytes: altered gene expression for detoxification enzymes

et al. 2007

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The effect of Schisandra fructus extract (SFE) on doxorubicin (Dox)-induced cardiotoxicity was investigated in H9c2 cardiomyocytes. Dox, which is an antineoplastic drug known to induce cardiomyopathy possibly through production of reactive oxygen species, induced significant cytotoxicity, intracellular reactive oxygen species (ROS), and lipid peroxidation. SFE treatment significantly increased cell survival up to 25%, inhibited intracellular ROS production in a time-and dosedependent manner, and inhibited lipid peroxidation induced by Dox. In addition, SFE treatment induced expression of cellular glutathione S-transferases (GSTs), which function in the detoxification of xenobiotics, and endogenous toxicants including lipid peoxides. Analyses of 31,100 genes using Affymetrix cDNA microarrays showed that SFE treatment up-regulated expression of genes involved in glutathione metabolism and detoxification [GST theta 1, mu 1, and alpha type 2, heme oxygenase 1 (HO-1), and microsomal epoxide hydrolase (mEH)] and energy metabolism [carnitine palmitoyltransferase-1 (CPT-1), transaldolase, and transketolase]. These data indicated that SFE might increase the resistance to cardiac cell injury by Dox, at least partly, together with altering gene expression, especially induction of phase II detoxification enzymes.

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“…The hepato-protective effect of Sch B against carbon tetra chloride toxicity was mediated by both enhancements of mitochondrial glutathione antioxidant status and heat shock proteins. (Zhu, Lin et al 1999;Tang, Chiu et al 2003). Further in in-vitro model Sch B elicits a glutathione antioxidant response and protects against apoptosis via the redox-sensitive ERK/Nrf2 pathway in AML12 heptocytes.…”

Section: The Antioxidant Potential Of Sch B In Various Organsmentioning

confidence: 99%

Schisandrin B, a Lignan from Schisandra chinensis Prevents Cerebral Oxidative Damage and Memory Decline Through Its Antioxidant Property

Konishi¹,

Giridharan²,

Thandavarayan³

2012

When Things Go Wrong - Diseases and Disorders of the Human Brain

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Evaluation of the protective effects of Schisandra chinensis on Phase I drug metabolism using a CCl4 intoxication model

Cited by 77 publications

References 6 publications

Influence of Supercritical CO<sub>2</sub> Extraction of Schisandra Chinensis on Antioxidant Status, Carcass and Meat Quality of AA Broilers

Influence of Supercritical CO<sub>2</sub> Extraction of Schisandra Chinensis on Antioxidant Status, Carcass and Meat Quality of AA Broilers

Schisandra fructus extract ameliorates doxorubicin-induce cytotoxicity in cardiomyocytes: altered gene expression for detoxification enzymes

Schisandrin B, a Lignan from Schisandra chinensis Prevents Cerebral Oxidative Damage and Memory Decline Through Its Antioxidant Property

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