Evaluation of the protective effects of hesperetin against cisplatin-induced ototoxicity in a rat animal model

Kara, Memduh; Türkön, Hakan; Karaca, Turan; Güçlü, Oğuz; Uysal, Sema; Türkyilmaz, Mehmet Kenan; Demirtaş, Selim; Dereköy, Fevzi Sefa

doi:10.1016/j.ijporl.2016.03.019

Cited by 25 publications

(7 citation statements)

References 21 publications

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“…In the current study, measurements taken from 4000 to 32000 Hz were evaluated and a statistically significant difference was determined between the days in the SNR measurements at 16000 Hz of the C+IP ADM group. When lycopene, hesperetin and melatonin, which have antioxidant properties, have been evaluated in cisplatin ototoxicity, the SNR of DPOAE at 6000 to 10000 frequencies has been determined to be statistically significant 18,19,20 . In a study conducted using tetramethylpyrazine, SNR was evaluated up to 35000 Hz and it was seen to have a protective effect on the cochlea.…”

Section: Biochemical Resultsmentioning

confidence: 99%

Efficacy of adrenomedullin on cisplatin ototoxicity in rats

Bilal

Kurutaş

Bahar

et al. 2019

Cukurova Medical Journal

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The aim of this study was to evaluate the efficacy of adrenomedullin on damage associated with cisplatin ototoxicity created in an experimental animal model. Materials and Methods: A total of 32 Wistar Albino rats were separated into 4 groups of 8. To the rats in Group 1 (control), 1% acetic acid was administered intraperitoneally and intratympanically, to Group 2, cisplatin (10mg/kg/2 days) + intratympanic acetic acid, to Group 3, cisplatin + intraperitoneal adrenomedullin (12 µg/kg) and to Group 4, cisplatin +0.1-0.3ml intratympanic adrenomedullin (12 µg/kg). The drugs were administered on the first 5 days and signal-to-noise ratio (SNR) measurements of the auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAE) were made on days 0, 5 and 15. The rats were sacrificed and serum and ear tissue samples were taken for histopathological examination and examination of oxidative stress levels. Results: A statistically significant difference was determined in the cisplatin+intratympanic adrenomedullin group in the Auditory brain-stem response (ABR) measurements on days 0, 5 and 15. In the Distortion product-evoked otoacoustic emission (DPOAE) measurements, the between-day differences at 16000 frequency in the cisplatin + intraperitoneal adrenomedullin group were accepted as statistically significant Conclusion: Adrenomedullin, which is a strong vasodilator and antioxidant, was found to have a protective effect against cisplatin ototoxicity in the cochlea.

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Section: Biochemical Resultsmentioning

confidence: 99%

Efficacy of adrenomedullin on cisplatin ototoxicity in rats

Bilal

Kurutaş

Bahar

et al. 2019

Cukurova Medical Journal

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“…Hesperetin and allopurinol were prepared in saline solution containing 1% Tween-80 immediately before the use to obtain a uniform suspension and the administrated volume was 10 mL/kg. Previous studies have shown that intraperitoneal administration of 20 mg/kg HSE can prevent ototoxicity by increasing antioxidant enzymes and reducing oxidation parameters, as well as prevent apoptosis caused by cochlear implant cell proliferation ( Kara et al, 2016 ), and the experimental dose adjustment in this study is based on this.…”

Section: Methodsmentioning

confidence: 99%

Anti-hyperuricemia effect of hesperetin is mediated by inhibiting the activity of xanthine oxidase and promoting excretion of uric acid

Shen

Zhang

et al. 2023

Front. Pharmacol.

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“…TUNEL-positive cells were counted in the spiral ligament, stria vascularis, and organ of Corti in each section. The ratio of TUNELpositive cells to all cells was calculated in percentage (%) [Kara et al, 2016].…”

Section: Immunohistochemistry Protocolmentioning

confidence: 99%

Does Oral Monosodium Glutamate Have a Cochleotoxic Effect? An Experimental Study

et al. 2021

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Introduction: The effect of orally consumed monosodium glutamate (MSG), which is a common additive in the food industry, on the cochlea has not been investigated. The present study aimed to investigate the possible cochleotoxic effects of oral MSG in guinea pigs using electrophysiological, biochemical, and histopathological methods. Methods: Thirty guinea pigs were equally divided into control and intervention groups (MSG 100 mg/kg/day; MSG 300 mg/kg/day). At 1 month, 5 guinea pigs from each group were sacrificed; the rest were observed for another month. Electrophysiological measurements (distortion product otoacoustic emission [DPOAE] and auditory brainstem response [ABR]), glutamate levels in the perilymph and blood samples, and histopathological examinations were evaluated at 1 and 2 months. Results: Change in signal-to-noise ratio at 2 months was significantly different in the MSG 300 group at 0.75 kHz and 2 kHz (p = 0.013 and p = 0.044, respectively). There was no statistically significant difference in ABR wave latencies of the guinea pigs given MSG compared to the control group after 1 and 2 months; an increase was noted in ABR thresholds, although the difference was not statistically significant. In the MSG groups, moderate-to-severe degeneration and cell loss in outer hair cells, support cells, and spiral ganglia, lateral surface junction irregularities, adhesions in stereocilia, and partial loss of outer hair cell stereocilia were noted. Conclusion: MSG, administered in guinea pigs at a commonly utilized quantity and route of administration in humans, may be cochleotoxic.

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Evaluation of the protective effects of hesperetin against cisplatin-induced ototoxicity in a rat animal model

Cited by 25 publications

References 21 publications

Efficacy of adrenomedullin on cisplatin ototoxicity in rats

Efficacy of adrenomedullin on cisplatin ototoxicity in rats

Anti-hyperuricemia effect of hesperetin is mediated by inhibiting the activity of xanthine oxidase and promoting excretion of uric acid

Does Oral Monosodium Glutamate Have a Cochleotoxic Effect? An Experimental Study

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