Evaluation of the Protection Provided by Hepatitis B Vaccination in India

Puliyel, Jacob; Naik, Pathik; Puliyel, Ashish; Agarwal, Kishore; Lal, Vandana; Kansal, Nimmi; Nandan, Devki; Tripathi, Vikas; Tyagi, Prashant; Singh, Saroj Kumar; Srivastava, Rajeev; Sharma, Utkarsh; Sreenivas, V.

doi:10.1007/s12098-017-2601-0

Cited by 5 publications

(7 citation statements)

References 11 publications

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“…Meanwhile percentage of high level seroprotection was declined from 73.2% in group A to 54.2% in group B. Also, the seroprotection rate under the age of 3 years was100% majority of them (77.3%) were high level seroprotected, similar results in regard to seroprotection rate under the age of 3 years were reported by Kumar et al, 2021 [22]. In the current study, approximately two thirds of seroprotected children under 4 years were high level seroprotected.…”

Section: Discussionsupporting

confidence: 82%

“…This variation in seroprotection rates may be due to uneven sample sizes in each category. This decrease in rate and level of seroprotection in group C compared to groups A and B in the current study may be logically a result to advance in years of age in group C as age is recognized as a well-established risk factor for gradual depletion of anti-HBs concentrations [18,22,23], or it may be a result to birth dose administration in groups A and B which is supposed to be the root cause for elevation in the rates and levels of seroprotection in these two groups (A and B).…”

Section: Discussionmentioning

confidence: 63%

“…An Indian multicentric study carried out by Puliyel et al, 2018 [21] on 2671 children reported total seroprotection occurrence in 70% of the participants. A recent Indian study, 68.86% was the overall seroprotection rate of 122 children aged 1 to 10 years after vaccination [22].…”

Section: Discussionmentioning

confidence: 94%

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Assessment of hepatitis B virus immune status among hepatitis B virus vaccinated children.

Bakr

Sherbini

Aboulela

et al. 2022

Microbes and Infectious Diseases

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Background:: Vaccination compared to other measures is considered the most efficient and cost-effective strategy against hepatitis B virus (HBV) infection which decreases the incidence of both HBV infection and hepatocellular carcinoma. This study involved 179 children vaccinated against HBV during infancy, and aimed to assess the immune status against HBV among HBV vaccinated children in different age groups. Methods: Participants were chosen according to previously settled inclusion and exclusion criteria. Recruited participants' ages ranged from 9 months till 10 years who had received the full routine infancy vaccination course. Participants were divided according to age into three groups: group A ages from 9 months to less than 2 years of age (41 children 22.9%), group B ages from 2 years to less than 5 years (64 children 35.8%), and group C ages from 6 years to 10 years (74 children 41.3%). Serum levels of antiHBs were measured. Results: Out of 179 participants, there were 154 children (86%) seroprotected, while 25 children (14%) were not. Moreover, 100% of children under 3 years were seroprotected. Seroprotection rate under 5 years was 95.2%. While in group C seroprotection rate was 73%. Males showed a slightly higher seroprotection rate than females although statically insignificant. Conclusion: Universal hepatitis B vaccination shows excellent effectiveness in Egypt. Total seroprotection rate (86%) is higher than in previous local and global studies that may return to the recent implementation of birth dose in Egypt.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 63%

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Assessment of hepatitis B virus immune status among hepatitis B virus vaccinated children.

Bakr

Sherbini

Aboulela

et al. 2022

Microbes and Infectious Diseases

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“…The national level surveys estimate proportion of fully immunized children. 8 However occasionally the benefits of preventing perinatal transmission are challenged. 9 In spite of recommendations from WHO, birth dose administration within 24 hours is not seriously evaluated.…”

Section: Discussionmentioning

confidence: 99%

Assessment of immunization among newborns: comparison between children delivered vaginally and by cesarean section

Narula¹,

Doke²,

Vaidya³

et al. 2020

Int J Community Med Public Health

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Background: Timely administration of vaccines, particularly for hepatitis B birth dose within 24 hours of birth is of immense importance. It is considered as an indicator of quality of immunization programme. This study aimed to assess effect of mode of delivery and type of hospital on immunization among newborns. Methods: This large multi-site study was conducted in Pune district having population of 9.43 million. A total of 13 hospitals were selected which included all government hospitals performing more than five cesarean sections per month, and one government and one private medical college hospital. Cesarean section and vaginally deliveries were enrolled in 1:1 ratio. Their children were followed till discharge. Data were collected by obstetrician or qualified nurse.Results: During study period 3,112 women were enrolled. The relative risk of not getting vaccine Hepatitis B birth dose before 24 hours among cesarean delivered newoborns was 1.08. The relative risk of not getting zero polio and BCG among cesarean delivered newborns was 0.71 and 0.76 respectively. All these differences were significant. The coverage for all vaccines was better in sub district hospitals than others. Coverage of all vaccines in government teaching hospital was better than private.Conclusions: Cesarean section enabled better coverage among newborns probably due to length of stay. Whereas the physical and mental stress after cesarean section resulted lesser coverage of hepatitis B birth dose within 24 hours. Opportunities of timely Hepatitis B birth dose administration were missed probably due to lack of knowledge among health workers about ideal timing.

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“…Puliyel et al [3] have statistically demonstrated that birth dose does not offer additional protection in a group 2671 children tested for HbsAg and HBcAb (infected if both positive) and HbsAb in 1413 children out of 2671, from north India. HbsAg positivity was taken as carrier.…”

mentioning

confidence: 99%

Hepatitis B Vaccination – Protection with and without Birth Dose?

Aggarwal

2018

Indian J Pediatr

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Evaluation of the Protection Provided by Hepatitis B Vaccination in India

Abstract: The present study lends support to the pragmatic approach of the Government to vaccinate babies born at home starting at 6 wk.

Cited by 5 publications

References 11 publications

Assessment of hepatitis B virus immune status among hepatitis B virus vaccinated children.

Assessment of hepatitis B virus immune status among hepatitis B virus vaccinated children.

Assessment of immunization among newborns: comparison between children delivered vaginally and by cesarean section

Hepatitis B Vaccination – Protection with and without Birth Dose?

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