Evaluation of the prognostic utility of the hemoglobin-to-red cell distribution width ratio in head and neck cancer

Tham, Tristan; Olson, Caitlin; Wotman, Michael; Teegala, Sireesha; Khaymovich, Julian; Coury, Josephine R.; Costantino, Peter D.

doi:10.1007/s00405-018-5144-8

Cited by 33 publications

(30 citation statements)

References 25 publications

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“…in their study of patients with ESCC (0.989). The value is also very similar to the cutoff values for OS (1.019) and event‐free survival (EFS) (1.037) reported by Tristan et al . in head and neck tumors, as well as to the cutoff HRR value (0.88) reported by Yakup et al .…”

Section: Discussionsupporting

confidence: 87%

“…Furthermore, the cutoff value of HRR in this study (0.985) was very similar to that reported by Sun et al 24 in their study of patients with ESCC (0.989). The value is also very similar to the cutoff values for OS (1.019) and event-free survival (EFS) (1.037) reported by Tristan et al 25 in head and neck tumors, as well as to the cutoff HRR value (0.88) reported by Yakup et al 26 in patients with NSCLC. Most importantly, the present study confirms that HRR can be used as an independent prognostic indicator in patients with SCLC.…”

Section: Discussionsupporting

confidence: 87%

“…Based on research related to Hb and RDW in malignant tumors, Sun et al 24 was the first to report the prognostic value of the baseline Hb-to-RDW ratio (HRR) in esophageal squamous cell carcinoma (ESCC) in 2016. They revealed that HRR was an important prognostic indicator of ESCC, and similar results have also been reported for other types of cancers 25,26 ; however, to date, no studies have evaluated the clinical significance of HRR in the prognosis of SCLC. Therefore, this study aimed to assess the prognostic role of baseline HRR in SCLC and to further explore the potential relationship between HRR and the clinical features of patients with SCLC.…”

Section: Introductionsupporting

confidence: 69%

“…Therefore, finding new and effective prognostic indicators is essential for improving the prognosis of patients with SCLC. Previous studies 24,25 have confirmed that HRR is associated with the prognosis of patients with ESCC, head and neck tumors, and other malignancies, but no relevant reports on patients with SCLC have been published. This study is the first to assess HRR in patients with SCLC, with the aim of evaluating the prognostic significance of baseline HRR in this population.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic value of baseline hemoglobin‐to‐red blood cell distribution width ratio in small cell lung cancer: A retrospective analysis

Yang

Tang

et al. 2020

Thoracic Cancer

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Background This study aimed to investigate the prognostic value of baseline hemoglobin‐to‐red blood cell distribution width ratio (HRR) in patients with small cell lung cancer (SCLC). Methods We retrospectively analyzed the medical records of patients with newly diagnosed SCLC who had received first‐line chemotherapy at the Department of Pulmonary Oncology of the PLA 307 Hospital between January 2008 and October 2018. The optimal cutoff value of the continuous variables was determined using the X‐tile software. Univariate and multivariate analyses were conducted using Cox proportional hazard models. The Kaplan‐Meier method was used for survival analysis, with differences tested using the log‐rank test. Results A total of 146 patients were included. The cutoff value for HRR was determined as 0.985. Statistically significant differences were observed in sex, smoking history, stage, radiotherapy combination, neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio, hemoglobin, and red blood cell distribution width between the high and low HRR groups. The median overall survival (OS) was nine and 17.5 months in the low and high HRR groups, respectively (P < 0.001). The median progression‐free survival (PFS) was five and 8.5 months, respectively (P < 0.001). Univariate and multivariate analyses showed low HRR to be an independent predictor of a poor prognosis for OS (hazard ratio = 3.782; 95% confidence interval, 2.151–6.652; P < 0.001) and PFS (hazard ratio = 2.112; 95% confidence interval, 1.195–3.733; P = 0.01) in SCLC. Conclusion Low HRR was associated with poorer OS and PFS in patients with SCLC and can be a potentially valuable prognostic factor for these patients. Key points The prognostic value of the baseline hemoglobin‐to‐red blood cell distribution width ratio was evaluated in patients with small cell lung cancer. In this population, this ratio was an independent predictor of overall survival and progression‐free survival. This ratio, an inexpensive and routine parameter, can be used as a prognostic factor in small cell lung cancer.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 87%

Section: Introductionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

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Prognostic value of baseline hemoglobin‐to‐red blood cell distribution width ratio in small cell lung cancer: A retrospective analysis

Yang

Tang

et al. 2020

Thoracic Cancer

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“…The association between high RDW and poor prognosis has been found in a variety of solid tumors including esophageal cancer, rectal cancer, hilar cholangiocarcinoma, and so on . The combinations of RDW with other factors have also been used to predict prognosis in patients with solid tumors . For hematological cancers, high RDW has been recognized as a poor prognostic factor in multiple myeloma, diffuse large B cell lymphoma, and chronic lymphocytic leukemia .…”

Section: Discussionmentioning

confidence: 99%

Association of red blood cell distribution width and outcomes in patients with mantle cell lymphoma

et al. 2019

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Red blood cell distribution width (RDW), which measures the range of variation of red blood cell volume, has been explored as a prognostic factor in multiple types of cancer. However, the role of RDW in mantle cell lymphoma (MCL), a rare type of non‐Hodgkin lymphoma with poor outcomes, remains to be determined. Therefore, we investigated the prognostic role of RDW in MCL. We found that 21 of 76 MCL patients (27.6%) had an abnormally elevated RDW (>15.7%). Abnormally elevated RDW was significantly associated with presence of B symptoms (P = 0.0020), elevated lactate dehydrogenase (LDH) (P = 0.0010), higher leukocyte count (P = 0.0345), higher simplified Mantle Cell International Prognostic Index (sMIPI) (P = 0.0194), and lower level of hemoglobin (Hb) (P < 0.0001). It was marginally associated with increased C‐reactive protein (P = 0.0862). RDW was significantly correlated with Hb level (r2 = 0.42) and LDH level (r2 = 0.19). 15.8% was determined as the best cutoff of RDW in predicting the survival outcome by the X‐tile software. Survival analysis revealed that high RDW (>15.8%) predicted shorter progression‐free survival (PFS) (hazards ratio [HR]: 3.14; P = 0.0005) and shorter overall survival (OS) (HR: 4.04; P < 0.0001). High RDW independently predicted both shorter PFS (P = 0.0493) and OS (P = 0.0118). RDW also improved the prognostic stratification based on sMIPI. In conclusion, our study identified RDW as a novel prognostic factor of clinical feasibility in the prognostication of MCL.

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Radioresistance or/and radiosensitivity of head and neck squamous cell carcinoma: biological angle

Li,

Gong,

Zhang

et al. 2023

Oral Maxillofac Surg

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Evaluation of the prognostic utility of the hemoglobin-to-red cell distribution width ratio in head and neck cancer

Cited by 33 publications

References 25 publications

Prognostic value of baseline hemoglobin‐to‐red blood cell distribution width ratio in small cell lung cancer: A retrospective analysis

Prognostic value of baseline hemoglobin‐to‐red blood cell distribution width ratio in small cell lung cancer: A retrospective analysis

Association of red blood cell distribution width and outcomes in patients with mantle cell lymphoma

Radioresistance or/and radiosensitivity of head and neck squamous cell carcinoma: biological angle

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