Evaluation of the Prognostic Factors and Significance of Lymph Node Status in Invasive Ductal Carcinoma of the Body or Tail of the Pancreas

Abstract

Lymph node metastasis was a significant and independent prognostic factor for the surgically resected pancreatic body or tail carcinoma. Furthermore, the lymph nodes attached to the pancreas were the most frequent metastatic nodes, and these lymph nodes were potential indicators predicting both tumor extension and survival after surgery for pancreatic body or tail carcinoma.

Laparoscopic distal pancreatectomy employing radical en bloc procedure for adenocarcinoma: Technical details and outcomes

“…Kim et al 29 proposed the reevaluation of the role of routine splenectomy for distal pancreatectomy based on a low incidence of splenic hilar LN metastasis. 29,30 Table IV. Short-and long-term outcomes in literature of LDP and ODP for adenocarcinoma Moreover, preservation of the spleen was reported to avoid the risk of postosplenectomy sepsis 31,32 and improve the oncological outcomes for gastric, colorectal, and pancreatic cancers.…”

Prognostic Implications of Lymph Node Metastases in Carcinoma of the Body and Tail of the Pancreas

“…11, 14, 8, and 9 in decreasing order, which was consistent with previous reports. 2,12,29 Current classifications of UICC and Japanese Pancreas Society for pancreatic cancer define ''N'' categories only based on anatomical location of the metastatic lymph nodes. In the latest UICC staging classification, N factor is classified into the following categories in pancreatic body and tail cancer: N0, no regional lymph node metastasis; and N1, lymph node metastasis in regional lymph nodes (which is equivalent to lymph node Nos.…”

FOXP3+ Lymphocyte Density in Pancreatic Cancer Correlates with Lymph Node Metastasis

“…Lymph node metastasis is clearly an important event in solid tumors pathogenesis, especially pancreatic cancer [15]–[18]. As lymph nodes are the sites of antigen presentation and immune response initiation, they may serve as early barriers that prevent tumor cell entry into the systemic circulation [19].…”