Evaluation of the profile of alopecia areata and the prevalence of thyroid function test abnormalities and serum autoantibodies in Iranian patients

Seyrafi, H; Akhiani, Maryam; Abbasi, Hamed; Mirpour, Sahar; Gholamrezanezhad, Ali

doi:10.1186/1471-5945-5-11

Cited by 64 publications

(67 citation statements)

References 19 publications

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“…Patients with thyroid diseases were on an average older and reported longer duration, but the results were not statistically significant. These results are consistent with a clinical study performed by Seyrafi et al [32]. They analyzed serum TgAb level in 123 Iranian patients with AA and found it to be elevated in 29.3% of study patients.…”

Section: Discusionsupporting

confidence: 81%

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Thyroid Autoimmunity in Patients with Skin Disorders

Kasumagić-Halilovic¹,

Begovic²

2012

Thyroid Hormone

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Section: Discusionsupporting

confidence: 81%

“…One of the main associations is with thyroid abnormalities. This association was further supported by an increased incidence of abnormal thyroid structure, function tests and/or presence of thyroid autoantibodies found in many studies [29][30][31][32].…”

Section: Introductionsupporting

confidence: 48%

Thyroid Autoimmunity in Patients with Skin Disorders

Kasumagić-Halilovic¹,

Begovic²

2012

Thyroid Hormone

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“…Anti-TPO ak pozitifliği erişkinlerde AA'lı hastalarda yapılan çalışmalarda %25'lere varan düzeyde görülebilmektedir 20,22 . Dört bin üçyüz otuz dört AA'lı olgunun komorbidite açısından incelendiği son bir çalışma da ise çocukluk yaş grubu da dahil olmak üzere yaş aralığına göre AA varlığının tiroidit, sistemik lupus eritematozus, atopik dermatit, psoriazis, RA gibi hastalıklara eşlik etme olasılığının anlamlı olarak arttığı gösterilmiştir 23 24 . Türkiye'de çocukluk çağındaki popülasyona ait TFT anomalilerine dair net bir bilgi bulunamamasına karşın, iyot eksikliğinin endemik olarak saptandığı ülkemizde TFT anomalilerinin beklenenden yüksek olabileceği göz önüne alınmalıdır.…”

Section: Discussionunclassified

“…TFT abnormalities were detected in 27% (n=24) of the patients. 24.7% (n=22) of these patients were diagnosed Amaç: Alopesi areata (AA) ani başlangıçlı, yama şeklinde saç dökülmesi ile ortaya çıkan ve sık görülen akkiz bir alopesi sebebidir. Bu çalışmanın amacı AA'nın Türk çocuk popülasyonunda epidemiyolojik ve klinik özellikleri ve birlikte görüldüğü diğer hastalıkları araştırmaktır.…”

Section: Methodsunclassified

Childhood alopecia areata: A study of 89 patients

Doğan¹,

Ersoy‐Evans²,

Gönç³

et al. 2014

TURKDERM

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Background and Design: Alopecia areata (AA) is a frequent type of acquired hair loss with a sudden onset. The aim of this study was to investigate the epidemiological and clinical features of AA and diseases associated with AA in the Turkish pediatric population. Materials and Methods:We retrospectively evaluated the medical data of patients under 16 years of age who were admitted to the pediatric dermatology outpatient clinic at Hacettepe University Hospital between 2006 and 2011 with a diagnosis of AA, alopecia totalis (AT) and alopecia universalis (AU). Results: A total of 89 patients (34 females and 55 males), were included in this study. The mean age of the subjects was 9.8±3.4 years (range:18 months-16 years). 9% (n=8) patients had other autoimmune diseases: Hashimoto's thyroiditis in 5, vitiligo in 1, juvenile rheumatoid arthiritis (JRA) in 1 and morphea in 1 patient. AA was located on the scalp in 86.5% (n=77) of the patients, 7.9% (n=7) of the patients had AA on the scalp together with eyelashes, eyebrows and the body. AT was noted in 1, AU was noted in 4 patients. Severity of hair loss was <25% in 94.3% (n=84) of the patients according to the involved area. Hashimoto's thyroiditis was diagnosed in 5 patients; these patients had normal thyroid function tests (TFT). TFT abnormalities were detected in 27% (n=24) of the patients. 24.7% (n=22) of these patients were diagnosed

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“…2 It is usually associated with various autoimmune diseases and maybe associated with a positive family history. 3,4 Its lifetime risk is reported to be 1.7%. 5 It is a common cause of localized hair loss in patients of age group 5 to 35 years who attend the outpatient department.…”

Section: Introductionmentioning

confidence: 99%

A randomized prospective study to evaluate the efficacy of various topical treatment modalities in patients of alopecia areata

Manthale¹,

Raikar

Raikar³

2017

Int J Res Dermatol

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Background:Alopecia areata (AA) is one of the common causes of localized hair loss among the patients attending the outpatient department. The objective of this study was to know the clinical and epidemiological profile of AA and to compare the efficacy of different topical treatment modalities in AA.Methods:100 patients of any age group and of both sexes presenting with AA to the dermatology outpatient department were included in this study. It was conducted as a randomized prospective study for a period of 12 weeks after taking an informed consent from the patient. After studying the clinical profile, patients were randomly distributed, excluding the age and sex bias into four treatment groups. Alopecia grading scale (AGS) was calculated at first visit and 12 weeks. Regrowth score (RGS) was calculated at 12 weeks. Treatment outcome in different groups were compared using mean AGS at 12 weeks and RGS.Results:Group A patients showed statistically significant clinical improvement when compared to all the other groups. Poorest response was seen in Group D. Intermediate response was seen in Group B and C patients.Conclusions:The study concluded that topical 0.05% betamethasone dipropionate is the most effective treatment modality in patients with patchy AA (having <25% hair loss).

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Evaluation of the profile of alopecia areata and the prevalence of thyroid function test abnormalities and serum autoantibodies in Iranian patients

Abstract: Background: The study aimed at evaluating the prevalence of thyroid function abnormalities in patients with alopecia areata (AA) and its association with other autoimmune diseases and various autoimmune antibodies.

Cited by 64 publications

References 19 publications

Thyroid Autoimmunity in Patients with Skin Disorders

Thyroid Autoimmunity in Patients with Skin Disorders

Childhood alopecia areata: A study of 89 patients

A randomized prospective study to evaluate the efficacy of various topical treatment modalities in patients of alopecia areata

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