Evaluation of the Prevalence of Urinary Tract Infection in Children with Febrile Seizure

Kazeminezhad, Behrang; Taghinejad, Hamid; Borji, Milad; Seymohammadi, Reza

doi:10.5812/compreped.62557

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…We report a UTI prevalence of 10.7%, comparable to that of other studies [6][7][8]. The results of our study that the most common etiological agents of UTIs are bacteria of enteric origin correlate with the results of other epidemiological studies [9][10][11][12][13].…”

Section: Discussionsupporting

confidence: 91%

Exploring Inflammatory Status in Febrile Seizures Associated with Urinary Tract Infections: A Two-Step Cluster Approach

Maniu

Costea

Băcilă

et al. 2020

1st International Electronic Conference on Brain Sciences

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Background: Urinary tract infections (UTIs) are considered common facilitating factors along with other infections in triggering febrile seizures (FS). The main purpose of our study was to identify specific patterns of UTIs, using a combination of inflammatory biomarkers, in order to differentiate UTIs from other bacterial diseases triggering FS. Method: This study included a number of 197 distinct FS events from patients hospitalized in the Pediatric Clinical Hospital Sibiu, among which 10.2% were diagnosed with UTIs. Results: In one-third of the patients with UTI, the symptoms were limited to fever and FS. Using Two-Step cluster analysis, a distinct inflammatory pattern has emerged: higher platelet distribution of the population (PDW), platelet large cell ratio (P-LCR), mean platelet volume (MPV), C-Reactive Protein (CRP), and neutrophil to lymphocyte ratio (NLR). This pattern was associated mainly with bacterial lower respiratory infections. UTIs were highly unlikely in the patients with significantly increased CRP values and normal values of platelet indices. Conclusion. Considering the nonspecific clinical picture of UTIs at an early age, to optimize the management of FS, a fast diagnosis of UTI is mandatory. Our study suggests that analyzing the inflammatory biomarkers interlinks (rather than individual parameters) could help identify even oligosymptomatic UTIs patients.

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Section: Discussionsupporting

confidence: 91%

Exploring Inflammatory Status in Febrile Seizures Associated with Urinary Tract Infections: A Two-Step Cluster Approach

Maniu

Costea

Băcilă

et al. 2020

1st International Electronic Conference on Brain Sciences

View full text Add to dashboard Cite

show abstract

“…We report a UTI prevalence of 10.7%, comparable to Abedi et al’s (11.1%) and Kazeminezhad et al’s (11.28%) research [ 18 , 19 ]. Shaikh et al’s meta-analysis on pediatric UTIs highlights a general prevalence of UTIs of 7.0% (CI: 5.5–8.4) [ 20 ].…”

Section: Discussionsupporting

confidence: 90%

“…We could not confirm in our study the UTI bimodal age model proposed in Leung et al’s meta-analysis. This model refers to a peak in the first year of life and another peak between 2–4 years, corresponding to the age of toilet training [ 18 , 19 , 20 , 21 , 22 , 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

Exploring Inflammatory Status in Febrile Seizures Associated with Urinary Tract Infections: A Two-Step Cluster Approach

et al. 2021

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Background: Urinary tract infections (UTIs) are considered common facilitating factors, along with other infections, in triggering febrile seizures (FS). The main purpose of our study was to identify specific inflammatory patterns of UTI cases from other infections in a specific cluster, using a combination of inflammatory biomarkers to differentiate UTIs from other bacterial diseases triggering FS. Method: This prospective study included a number of 136 patients with 197 distinct FS events, from patients hospitalized in the Pediatric Clinical Hospital Sibiu, among which 10.2% were diagnosed with UTIs. Results: In one-third of the patients with UTIs (20 cases), the symptoms were limited to fever and FS. Using two-step cluster analysis, a distinct UTI inflammatory pattern has emerged: highest platelet values (PLT), median value 331 × 103/mm3 and intermediate C-reactive protein (CRP), median value 15 mg/dL, platelet distribution width (PDW), median value 9.65%, platelet-large cell ratio (P-LCR), median value 14.45%, mean platelet volume (MPV), median value 8.60 fL and neutrophil-to-lymphocyte values (NLR), median value 3.64. Furthermore, higher PDW (median value 12.25%), P-LCR (median value 28.55%), MPV (median value 10.40 fL), CRP (median value 74.00 mg/dL) and NLR values (median value 4.11) were associated mainly (85.7%) with bacterial lower respiratory infections. UTIs were highly unlikely in these patients with significantly increased CRP values and normal values of platelet indices. Conclusions: Considering the nonspecific clinical picture of UTIs at an early age, to optimize the management of FS, a fast diagnosis of UTI is mandatory. The analysis of the inflammatory biomarker clusters (rather than individual parameters) correlated with urine leukocyte and nitrite stick evaluation for specific age groups could help in identifying even oligosymptomatic UTIs patients. The study limitation (20 UTI cases) recommends future multicentric trials on larger datasets to validate the model.

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“…However, this condition and its consequences can be avoided if the appropriate steps are taken. 8 Therefore, it is essential to understand the underlying causes and complications of this condition and to work toward their solution.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Renal Function and Urinalysis in Children With Simple Febrile Convulsions

Ahmadi

Shariatmadari

Yousefichaijan

et al. 2022

Clin Pediatr (Phila)

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Febrile convulsion (FC) is the most prevalent type of seizure in children. Febrile diseases have been associated with alterations in kidney function and urine indices. Therefore, in this study, renal function and urine analysis were examined in children with simple FC. The study comprised children with simple FC who were referred to the Amirkabir hospital in Arak between 2020 and 2021. Children were examined for urinalysis and kidney function by assessing the estimated glomerular filtration rate (eGFR). A total of 157 patients with FC were admitted. Hematuria, proteinuria, and pyuria were detected in 8.9%, 1.9%, and 5.1% of cases, respectively. The urine cultures of 2 children were positive. Moreover, it was found that in simple FC, eGFR decreases regardless of gender ( P > .05), although kidney function decreases more in children older than 24 months. In conclusion, all children with FC must undergo renal function assessments. Furthermore, urinalysis and urine culture are advised to rule out infection.

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Evaluation of the Prevalence of Urinary Tract Infection in Children with Febrile Seizure

Cited by 5 publications

References 11 publications

Exploring Inflammatory Status in Febrile Seizures Associated with Urinary Tract Infections: A Two-Step Cluster Approach

Exploring Inflammatory Status in Febrile Seizures Associated with Urinary Tract Infections: A Two-Step Cluster Approach

Exploring Inflammatory Status in Febrile Seizures Associated with Urinary Tract Infections: A Two-Step Cluster Approach

Evaluation of Renal Function and Urinalysis in Children With Simple Febrile Convulsions

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