Evaluation of the Prevalence of Temporomandibular Joint Involvement in Rheumatoid Arthritis Using Research Diagnostic Criteria for Temporomandibular Disorders

Mortazavi, Nazanin; Babaei, Mansour; Babaee, Neda; Kazemi, Hamed Hossein; Mortazavi, Roozbeh; Mostafazadeh, Amrollah

doi:10.18502/jdt.v15i6.325

Cited by 9 publications

(14 citation statements)

References 21 publications

(30 reference statements)

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“…However, we did not find any data regarding the possible relationship between salivary citrulline/ACPA and TMJ involvement. This finding is in accordance with reports previously published 18 , 19 , 33 .…”

Section: Discussionsupporting

confidence: 94%

“…We could just find a relationship between TMJ involvement and periodontal disease staging, which is somehow an obvious finding, as periodontal staging is based on MT, what is a risk factor for TMJ problems. Earlier there was a study, where significant relationship between serum anti-CCP and TMJ involvement was found 18 . However, we did not find any data regarding the possible relationship between salivary citrulline/ACPA and TMJ involvement.…”

Section: Discussionmentioning

confidence: 99%

“…TMJs were examined according to standard methods to reveal possible involvement both the patient and control groups 18 , 19 . Saliva samples were taken by the spitting method into a 50 mL centrifuge tube 20 .…”

Section: Methodsmentioning

confidence: 99%

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Salivary citrullinated proteins in rheumatoid arthritis and associated periodontal disease

Tar

Csősz

Végh

et al. 2021

Sci Rep

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Periodontal disease (PD) can be an important precipitating factor in the production of citrullinated proteins. Its importance is emphasized, but it is not the only way to produce citrullinated proteins. The aim of the current study was to determine the periodontal conditions and the salivary citrullinated protein content in patients with rheumatoid arthritis (RA) compared to healthy controls. We also wished to correlate citrullinated protein levels in the saliva and serum biomarkers with the periodontal status and temporomandibular joint (TMJ) involvement of patients with RA. Twenty-three patients with RA and 17 healthy controls participated the study. Saliva samples were taken: citrulline content of saliva was measured. Blood test results for patients with RA were collected. TMJ disorders were described. Cariological and periodontal indices were registered. Periodontal conditions and periodontal staging were also registered. Comparison of measured values between groups was performed. Intragroup correlation of patients’ values was counted. The prevalence of TMJ complaints was significantly higher in the RA group (8/23) versus controls (1/17). The patients with RA had worse periodontal condition because more patients with RA had gingivitis with a significantly higher bleeding on probing (BOP) (RA: 22.4 ± 25.0%; controls: 6.36 ± 11.6%; p = 0.018). Gingival index (GI) was also significantly higher in the patients than in controls (RA: 0.68 ± 0.58; controls: 0.19 ± 0.38; p = 0.010). The citrullinated protein (relative) content of saliva did not differ significantly (p = 0.147) between patients with RA (1102.2 ± 530.8) and healthy controls (1873.1 ± 1594.9). In RA, the salivary anti-CCP levels positively correlated with PD staging (R = 0.464, p = 0.039) . Control subjects more commonly had healthy gingiva than RA patients. Moreover, in the control group more individuals had intact and reduced height periodontium than periodontitis compared to the RA group. There was no significant difference in the levels of salivary citrulline between patients with RA and controls, despite the significant differences in their periodontal status. Thus, salivary citrulline levels are not associated with RA disease severity.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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Salivary citrullinated proteins in rheumatoid arthritis and associated periodontal disease

Tar

Csősz

Végh

et al. 2021

Sci Rep

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“…Once temporomandibular joint (TMJ) is the unique synovial orofacial joint, it can be frequently affected in RA, including condylar and disc alterations 8 . However, literature is variable in reporting the frequency of temporomandibular disorder (TMD) due to RA [8][9][10] . Some authors found the presence of limited mouth opening 11 , TMJ pain 10,11 , muscular hyperactivity, and masticatory damage 12 .…”

Section: Introductionmentioning

confidence: 99%

“…However, literature is variable in reporting the frequency of temporomandibular disorder (TMD) due to RA [8][9][10] . Some authors found the presence of limited mouth opening 11 , TMJ pain 10,11 , muscular hyperactivity, and masticatory damage 12 . Still, some risk factors have been associated with the involvement of TMJ in patients with RA, as being of female gender, presence of mental disorders, insomnia or stroke 13 .…”

Section: Introductionmentioning

confidence: 99%

Removable prostheses improve OHRQL and satisfaction of elderly people with rheumatoid arthritis

et al. 2020

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Rheumatoid arthritis (RA) is an autoimmune disease that affects joint tissues and causes severe physical and functional impairments on quality of life due to muscular and articular pain. The involvement of temporomandibular joint in RA interferes with mouth opening and masticatory process. However, no studies addressed the impact of RA on oral health-related quality of life (OHRQoL) and satisfaction with prostheses use in elderly people. Aim: This study assessed the impact of oral rehabilitation with conventional dentures on the OHRQoL and prostheses satisfaction in elderly patients with RA, associated or not with temporomandibular disorder (TMD). Methods: Forty-five elderly were enrolled and divided into three groups: (1) RA and TMD (n=15, experimental), (2) RA without TMD (n=15, experimental), and (3) without RA and without TMD (n=15, control). The OHRQoL and the prostheses satisfaction were evaluated before and after new oral rehabilitation with partial and/or complete dentures. The OHRQoL and prosthesis satisfaction were assessed and verified through OHIP-14 questionnaire and visual analogue scale, respectively. Results: TMD group exhibited the worst mean values (P<0.05) for all OHIP-14 domains before insertion of new dentures. Group 2 showed worst means (P<0.05) compared to controls for functional limitation and physical pain domains of the OHIP-14, but not in the general score. Patients showed better outcomes of satisfaction with prostheses use only after the new rehabilitation. Conclusion: The use of new and well-fitted dentures improves all domains of OHRQoL in patients with RA and TMD and all groups were satisfied with prostheses use after the new rehabilitation with conventional dentures.

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Correlation of clinical findings of temporomandibular joint with serological results in rheumatoid arthritis patients

Jalal

Ahmed

Saeed

et al. 2022

Clinical & Exp Dental Res

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Objectives This study aimed to determine the frequency of temporomandibular joint (TMJ) involvement in patients with rheumatoid arthritis (RA) and to find out the correlation of serological tests with clinical symptoms of TMJs in RA patients. Patients and Methods This cross‐sectional study was performed on 40 patients with RA classified into two groups according to their duration of the disease. Clinical examination as well as laboratory tests were done for participants. Results The frequency of TMJ involvement clinically was 15% in Group A and 40% in Group B. The most frequently observed clinical symptom was facial pain (25%), and the slightest symptom was clicking (2.5%) during mouth opening. There was a positive correlation between ESR, RF, CRP and anti‐CCP and clinical sign and symptoms of TMJs in RA patients. An elevated ESR, RF CRP and anti‐CCP may indicate the presence of TMJ complains in RA patients. The chronicity of RA affects the frequency of TMJ involvement clinically, patients with longer disease duration have more clinical symptoms of TMJs. An elevated level of ESR, RF, CRP and anti‐CCP predict clinical symptoms of TMJs.

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Evaluation of the Prevalence of Temporomandibular Joint Involvement in Rheumatoid Arthritis Using Research Diagnostic Criteria for Temporomandibular Disorders

Cited by 9 publications

References 21 publications

Salivary citrullinated proteins in rheumatoid arthritis and associated periodontal disease

Salivary citrullinated proteins in rheumatoid arthritis and associated periodontal disease

Removable prostheses improve OHRQL and satisfaction of elderly people with rheumatoid arthritis

Correlation of clinical findings of temporomandibular joint with serological results in rheumatoid arthritis patients

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