Evaluation of the Prevalence of Prolonged QT Syndrome in Children with First Unprovoked Seizure

Katibeh, Parisa; Inanloo, Soroor; Katibeh, Pegah

doi:10.5742/mewfm.2018.93251

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…2 This shows that long-term treatment is a protective but with no protective effect against development of epilepsy. In this regard, in a study conducted by Katibeh et al, 23 in Southern Iran, 100 patients were impressed with first unprovoked seizure, 1% of the patients had long QTc with no significant sex differences, types of seizure, and other ECG parameters.…”

Section: Discussionmentioning

confidence: 91%

Electrocardiography Findings in Children with Febrile Convulsion

Noori

Khajeh

Teimouri

2020

Journal of Pediatric Neurology

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Febrile convulsion (FC) is a seizure associated with body temperature that leads to electrocardiography changes. The study aimed to study electrocardiographic changes in children with FC as compared with healthy children. In this case–control study, 90 children aged 6 to 60 months were matched with equal healthy ones in “Ali Ebne Abi Talib” hospital in Zahedan, Iran. FC was confirmed by a neurologist based on its definition by the International League Against Epilepsy. Electrocardiogram (ECG) was captured by a pediatric cardiologist. Data were analyzed using SPSS 19. Sex distribution in groups was similar (p = 0.232). QT correction (QTc) was normal in 97.8 and 76.7% of controls and FC children, respectively (p < 0.001). QT dispersion (QTd) was normal in all controls when it was prolonged in 0.6% of children (p< 0.316). Calculated QT (QTcd) prolonged in controls and FC of 4.4 and 27.8% of children, respectively (p < 0.001). RR interval (p = 0.001), heart rate (p< 0.001), S in V1 (p = 0.004), R in aVL (p = 0.007), S in V3(p< 0.001), left ventricular mass (LVM) (p< 0.001), QTd (p< 0.001), QTc max (p< 0.001), and QTcd (p< 0.001) were significant. Means of LVM were 46.00 ± 1.86, 47.22 ± 2.24, and 51.45 ± 2.41 for age groups of <12, 12–24, and >24 months, respectively (p < 0.001). We conclude that QTd, QTc, and QTcd were higher in FC compared with those of healthy children. The rate of FC in children with higher level of QTcd increased compared with controls.

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Section: Discussionmentioning

confidence: 91%

Electrocardiography Findings in Children with Febrile Convulsion

Noori

Khajeh

Teimouri

2020

Journal of Pediatric Neurology

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“…Concerning gender, our study indicates that epilepsy is more common among females, it is about 51 % compared to males who were 49 %. Similarly, another study indicated that the rate of influence in gender is generally close to the two genders, according to their findings., of Shiraz city in Iran, who are primarily male children in Shiraz were affected, then females and affected age 3 to 12 years old in the same research, Compared to children under 18 in Sulaimaniyah city in 104 cases of epilepsy in children 54 affected and exposure with epilepsy especially generalized seizure and 52 contains female with epilepsy and common in both genders, where the majority of epilepsy is male, but we are not found the child order in the family influence epilepsy more [18].…”

Section: Discussionmentioning

confidence: 54%

Epilepsy and Child History in Dr. Jamal Ahmad Rashid Pediatric Teaching Hospital Sulaymaniyah /Iraq

Abdulkareem¹

2022

KJAR

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Epilepsy is a chronic neurological illness that is the most prevalent severe brain problem worldwide .The purpose of this research is to determine the importance of certain risk variables for epilepsy in children in Sulaimani City, such as age, gender, head trauma, nervous system infectious diseases including meningitis and unusual perinatal history, low birth weight, neonate respiratory failure, neonatal seizure, socioeconomic status, as well as parent consanguinity. This research was created based on 104 cases (where 51 of the patients were male, while 53 of the patients were female) among the inpatient and outpatient neurology unit of Dr. Jamal Ahmad Rashid Pediatric teaching Hospital from 20/12/2020 to 29/4/2021 . In this research, all the children were evaluated, as well as their medical & personal information were collected .A relation between the phenomenon of epilepsy with numerous risk factors were made; the ratio was calculated to determine the essential variables linked with epilepsy. Data was collected through interviewing of the patients then analyzed through the application statistical analysis descriptive. Results: age, head trauma, gender, febrile, positive family history for epilepsy, unusual perinatal history, and neonatal infection has been shown to have a statistically significant link to epilepsy. Conclusion: The majority of the samples was aged between six to ten while most of them were the middle child of their families. The results of survey also showed that most of the children were diagnosed between ages one to five while most of the samples have a generalized seizure. On the other hand, there was a statistical significant association between febrile convulsion and family history of epilepsy depending. Recommendation: Health staff (maternity staff) should not be excessively forced to pull the child's delivery. Informing the child's parents about the disease so that they do not become worried about any neurological disorders, our recommendation for staff working neurology field neurologist when such child enter the hospital immediately and quickly and get the necessary treatment.

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“…After analysis, they found a difference in QT prolongation between case and control groups. In another study in Iran by Katibeh et al, 25 100 patients were impressed with first unprovoked seizure, 1% of the patients had long QTc, regardless of sex and types of seizure. In a previous study, we concluded that RR interval, HR, S wave in lead V 1 , R in aVL, LVM, QTd, QTc, and QTcd prolonged significantly in FC children compared with controls.…”

Section: Discussionmentioning

confidence: 91%

Electrocardiography Parameters Changes in Epilepsy and Febrile Convulsion Children Compared with Controls

Noori

Teimouri

Khajeh

2020

Journal of Pediatric Epilepsy

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AbstractEpilepsy and febrile convulsion are the most common neurological diseases with significant effect on cardiac functions. The study aimed to evaluate electrocardiography parameters alterations in epilepsy and febrile convulsion children compared with controls. In this comparison study, 270 children analyzed who shared equally in epilepsy, febrile convulsion, and healthy that aged from 0.5 to 5 years. The participants were collected from Ali ibn Abi Talib Hospital of Zahedan, Iran. Epilepsy confirmed based on definition of having at least two unprovoked seizures in 24 hours. Febrile convulsion was confirmed based on its definition by the International League against Epilepsy. Healthy children selected from those referred to the hospital with fever and without any underline diseases. Electrocardiography was performed by a pediatric cardiologist. Data were analyzed using SPSS 19 with p < 0.05 significant level. Heart rate was higher in epilepsy (129.64 ± 27.63) compared with control (108.78 ± 26.01) and febrile convulsion (125.79 ± 25.38; X 2 = 28.701, p < 0.001). S wave in lead V1 was higher in controls (0.72 ± 0.36) compared with epilepsy (0.58 ± 0.45) and febrile convulsion (0.58 ± 0.36). QT dispersion and QTc dispersion levels were higher in epilepsy than febrile convulsion children that both were higher than controls. Concluded that R in aVL, LV mass (LVM), QT dispersion, and QTc dispersion were higher significantly in epilepsy compared with febrile convulsion children. To maintain a good strategic treatment in patients with epilepsy and febrile convulsion, there is a need to assess alternations in ECG parameters, especially QT interval changes that lead to better comprehensive autonomic changes.

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Evaluation of the Prevalence of Prolonged QT Syndrome in Children with First Unprovoked Seizure

Abstract: Background: The long QT syndrome (LQTS) is a disorder of myocardial repolarization characterized by a prolonged QT interval on the ECG. This syndrome may be congenital or acquired and it can be associated with seizure-like symptoms. ECG is used routinely to diagnose this syndrome.

Cited by 4 publications

References 17 publications

Electrocardiography Findings in Children with Febrile Convulsion

Electrocardiography Findings in Children with Febrile Convulsion

Epilepsy and Child History in Dr. Jamal Ahmad Rashid Pediatric Teaching Hospital Sulaymaniyah /Iraq

Electrocardiography Parameters Changes in Epilepsy and Febrile Convulsion Children Compared with Controls

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