Evaluation of the prescription and use of antibiotics in Brazilian children

Fiol, Fernando de Sá Del; Lopes, Luciane Cruz; Barberato‐Filho, Silvio; Motta, Cristiane de Cássia Bergamaschi

doi:10.1016/j.bjid.2012.10.025

Cited by 15 publications

(17 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A study by Del Fiol et al [ 36 ], that analyzes the use of antibiotics in children in two Health Centers in Brazil, reports that 50% of the prescribed dosages of amoxicillin are under the recommended amounts according to Brazilian guidelines. These results are similar to those in our study that show 57.35% of prescriptions were under the recommended dose for the same antibiotic in children.…”

Section: Discussionmentioning

confidence: 99%

“Appropriateness and adequacy of antibiotic prescription for upper respiratory tract infections in ambulatory health care centers in Ecuador”

Choez

Acurio

Jimbo

2018

BMC Pharmacol Toxicol

View full text Add to dashboard Cite

BackgroundUpper respiratory tract infections are the leading cause of misuse of antibiotics, a problem that leads to unnecessary adverse events and antibiotic resistance. Antibiotic prescription in Ecuador was analyzed in order to evaluate the state of antibiotic prescribing for upper respiratory tract infections. Both the appropriateness and adequacy of prescribing was evaluated. Appropriateness represents the percentage of prescriptions that are indicated; adequacy refers to the percentage of patients requiring antibiotics who are treated.MethodsThe aim of the study is to analyze the appropriateness and adequacy of antibiotic prescription for upper respiratory tract infections in the Ambulatory Health Centers of the Ministry of Public Health of Ecuador. This is a cross-sectional study of patients from one Health Center of the Ministry of Public Health in the District 17D03 in Ecuador during 2015 with upper respiratory tract infection as a primary diagnosis.ResultsWe included a total of 1393 patients in the analysis. Out of the 1393 patients identified, 523 were prescribed antibiotics, constituting an antibiotic prescription rate of 37.5%, and 51 required antibiotics, reflecting a real need of antibiotics of 3.7%. Appropriateness: Of these 523 patients who were treated, 51 required an antibiotic, resulting in an appropriate antibiotic prescription rate of 9.75%. Adequacy: When analyzing each individual case, 33 of these 51 patients received an antibiotic, constituting an adequate prescription rate of 64.7%.ConclusionsThe results of our study report a 90.25% of inappropriate prescription. The antibiotic prescription, appropriate prescription, and adequate prescription rates show the need for implementation of strategies in order to reduce them. Related aspects regarding prescriber’s behavior and the patient’s expectations should be analyzed.Electronic supplementary materialThe online version of this article (10.1186/s40360-018-0237-y) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

“Appropriateness and adequacy of antibiotic prescription for upper respiratory tract infections in ambulatory health care centers in Ecuador”

Choez

Acurio

Jimbo

2018

BMC Pharmacol Toxicol

View full text Add to dashboard Cite

show abstract

“…Although, microbiological diagnosis is important for obtaining accurate diagnosis of bacterial infection, its utility in routine clinical practice is limited by a number of factors41,50 including time constraints or delay in obtaining laboratory results - usually 24 -72 hours in most cases, expertise required for appropriate specimen collection and processing, as well as costs of laboratory investigations among others. Thus, the clinical manifestations presented by a patient may help in making decision for empirical antibiotic therapy especially for acute infections in under-five children where prompt clinical diagnosis and treatment are desired to avert fatal consequence(s)46,48,51. In such situation, the initial antibiotic selection for empirical therapy should rely on broad-spectrum agents until culture and sensitivity data are available to determine the implicated organism( s).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of antibiotic prescriptions and use in under-five children in Ibadan, SouthWestern Nigeria

Adisa¹,

Orherhe²,

Fakeye³

2018

Afr H. Sci.

View full text Add to dashboard Cite

BackgroundIrrational antibiotic prescriptions for children is a global concern requiring periodic evaluation and monitoring.ObjectivesTo assess appropriateness of antibiotic prescribing for under-five children, as well as evaluating mothers' usage of antibiotics for their under-five and reason(s) for use.MethodCross-sectional review of out-patient case-notes of under-five using principles of antibiotic prescribing and a questionnaire-guided interaction with under-five mothers.ResultsNearly all (445;98.9%) antibiotic prescriptions were based on signs and symptoms indicative of bacterial infection. Only 3(0.7%) had the initial antibiotic regimen modified. Nine (2.0%) had documented evidence of sensitivity test requested before antibiotic prescribing. Presence of infection or need for antibiotic therapy was established in 190(42.2%). Majority (324;72.0%) of mothers had administered antibiotics to their under-five. Of these, 157(48.5%) were prescribed by physicians and 79(24.4%) were self-recommended. Educational status of mothers significantly influenced antibiotic usage.ConclusionAntibiotic prescriptions for under-fives was largely based on symptoms indicative of bacterial infections, thereby corroborating the widespread empirical antibiotic prescribing. Considerable number of mothers engaged in self-recommendation of antibiotics for their under-fives. Thus, there is a need for continuous enlightenment of prescribers and mothers on rational use of antibiotics, while microbiological confirmation of clinical diagnosis is encouraged for evidence-based antibiotic prescribing.

show abstract

“…[13,23] The reasons for parenteral use included the clinical condition of the patient, the need for rapid action, the belief that injectable antibiotics are more potent, and the availability of injectable antibiotics. [14,16,23,24] Children <5 years old received antibiotics more often than older children, possibly owing to more severe clinical conditions in younger patients. [25] In addition, regardless of laboratory confirmation, clinical conditions played an important role in the use of antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Determinants of antibiotic prescription in paediatric patients: The case of two hospitals in Maputo, Mozambique

et al. 2017

View full text Add to dashboard Cite

show abstract

Evaluation of the prescription and use of antibiotics in Brazilian children

Cited by 15 publications

References 36 publications

“Appropriateness and adequacy of antibiotic prescription for upper respiratory tract infections in ambulatory health care centers in Ecuador”

“Appropriateness and adequacy of antibiotic prescription for upper respiratory tract infections in ambulatory health care centers in Ecuador”

Evaluation of antibiotic prescriptions and use in under-five children in Ibadan, SouthWestern Nigeria

Determinants of antibiotic prescription in paediatric patients: The case of two hospitals in Maputo, Mozambique

Contact Info

Product

Resources

About