Evaluation of the Potential Role of Echocardiography in the Detection of Allograft Rejection in Heart Transplant Recipients

Sade, Leyla Elif; Sezgin, Atilla; Uluçam, Melek; Taymaz, S.; Simsek, Vahide; Tayfun, Egemen; Tokel, Kürşad; Aşlamacı, Sait; Müderrisoğlu, Haldun

doi:10.1016/j.transproceed.2005.12.098

Cited by 18 publications

(15 citation statements)

References 7 publications

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“…However, this result could not be reproduced in more recent studies. [8][9][10] We have found a significant relationship between several diastolic DTI parameters and ACR in univariate analysis, such as lateral E 0 velocity and lateral E/E 0 ratio. The utility of myocardial deformation in the detection of ACR has been investigated, with promising results.…”

Section: Discussionmentioning

confidence: 70%

“…4,5 Diastolic measurements and Doppler tissue imaging (DTI) parameters have also shown conflicting results. [6][7][8][9][10] The utility of myocardial strain and strain rate in the diagnosis of ACR is still under discussion. DTI-derived deformation parameters have been tested in different studies, with high diversity in their cutoff points and consequently with poor reproducibility.…”

mentioning

confidence: 99%

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Usefulness of Two-Dimensional Strain Parameters to Diagnose Acute Rejection after Heart Transplantation

Mingo¹,

Moñivas-Palomero²,

García‐Lunar³

et al. 2015

Journal of the American Society of Echocardiography

107

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Section: Discussionmentioning

confidence: 70%

mentioning

confidence: 99%

Usefulness of Two-Dimensional Strain Parameters to Diagnose Acute Rejection after Heart Transplantation

Mingo¹,

Moñivas-Palomero²,

García‐Lunar³

et al. 2015

Journal of the American Society of Echocardiography

107

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“…The apparent limited value of TDI across these studies may be related to the exaggerated overall motion of the transplanted heart, which markedly influences TDI values,25 and the reproducibility of TDI measurements, which as demonstrated in other clinical situations, is often low 29. TDI parameters are also affected by other factors such as systemic infection 30. As such, TDI does not form part of ACAR surveillance in most centres.…”

Section: Imaging Techniquesmentioning

confidence: 99%

Non-invasive approaches for the diagnosis of acute cardiac allograft rejection

Miller

Fildes

Ray

et al. 2012

Heart

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Despite modern immunosuppressive regimes, acute rejection remains a leading cause of morbidity and mortality in heart transplant recipients. Clinical features are unreliable, and therefore, screening is performed in order to detect rejection, and hence, augment immunosuppressive therapy, at an early stage, with the aim of reducing short- and long-term sequelae. Histological analysis of right ventricular myocardial tissue obtained at endomyocardial biopsy remains the 'gold standard' surveillance technique; however 'biopsy-negative' rejection occurs in up to 20% of patients, the procedure is associated with uncommon but potentially serious complications and it is expensive. Non-invasive screening would, conceivably, be safer, more tolerable and cheaper, and could potentially allow more comprehensive monitoring. The evidence for non-invasive methods of diagnosing acute rejection, including assessment of myocardial deformation, myocardial tissue characterisation, electrophysiological monitoring, visualisation of cellular and molecular components of rejection and peripheral monitoring of immune activation, is reviewed.

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“…38,39 CONCLUSIONS Tricuspid valve regurgitation of the donor heart after cardiac transplantation is a real-world problem. A significant minority of patients develop debilitating clinical symptoms of right-heart failure that necessitate tricuspid valve surgery.…”

Section: Echocardiographymentioning

confidence: 99%