Cefpodoxime proxetil (CP) is an oral third generation cephalosporin antibiotic with effectiveness against most Gram positive and Gram negative bacteria. Commonly used to treat acute otitis media, pharyngitis, and sinusitis, CP is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime. Quality control evaluation of oral antibiotics has paramount importance to monitor the distribution of drugs in retail market and ensure the therapeutic efficacy against susceptible microorganism. The present work was performed to assess the quality control parameters of four brands of Cefpodoxime proxetil 200mg tablets available in Dindigul district. All the samples were analyzed for weight variation test, hardness, disintegration studies, percentage drug release by dissolution studies and percentage drug content determination by UV spectroscopic methods. The mean percentage drug content of Cefpodoxime proxetil varies from 93.9% w/w and 99.4% w/w among the products. The average hardness of the products varies from 5.5kg/cm2 to 9.33kg/cm2 respectively. All the brands had shown disintegration time 1.02 and 3.43 minutes while they showed 93.15% to 94.95% release of active ingredient within 30 minutes in dissolution studies. The present study revealed that all the brands of Cefpodoxime proxetil tablet met the quality control parameters as per pharmacopoeial specifications.