Evaluation of the penetration of ciprofloxacin and amoxycillin into the bronchial mucosa.

Honeybourne, D.; Andrews, J. M.; Ashby, J. P.; Lodwick, R; Wise, R.

doi:10.1136/thx.43.9.715

Cited by 63 publications

(36 citation statements)

References 13 publications

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“…In cases of lower respiratory tract infections, chemical analysis of sputum (6,9,28) and analyses of tissue biopsy specimens and bronchoalveolar lavage fluid (15,32), epithelial lining fluid (4,35), and alveolar macrophages (12,13) have been performed to obtain information about the penetration of antibiotics into the lungs (3,16). However, the determination of concentrations of antibiotics in sputum is unreliable.…”

Section: Discussionmentioning

confidence: 99%

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Penetration of Meropenem into Pneumonic Human Lung Tissue as Measured by In Vivo Microdialysis

Tomaselli

Maier

Matzi

et al. 2004

Antimicrob Agents Chemother

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Until recently, information on antibiotic pharmacokinetic properties in infected human lung tissue was limited. We therefore studied a microdialysis-based approach for measurement of the penetration of meropenem into the extracellular space fluid of human pneumonic lung parenchyma. The lung penetration of meropenem was determined for seven patients with pneumonia and metapneumonic pleural empyema treated by decortication. Intraoperatively, two microdialysis probes were inserted into pneumonic lung tissue and one was inserted into healthy skeletal muscle for reference values.

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Section: Discussionmentioning

confidence: 99%

“…Concentrations of antibiotics have been measured in sputum samples (6,9,19,28), bronchoscopically harvested biopsy specimens, and bronchoalveolar lavage fluids (15,32). More sophisticated approaches include the determination of antibiotic concentrations in epithelial lining fluid (4,35) or in alveolar macrophages (12,13).…”

mentioning

confidence: 99%

Penetration of Meropenem into Pneumonic Human Lung Tissue as Measured by In Vivo Microdialysis

Tomaselli

Maier

Matzi

et al. 2004

Antimicrob Agents Chemother

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“…AMs reside in this microenviron- (7,47). This sputum pooling invalidates measurements of antimicrobial agent concentrations with respect to the time of dosing and allows time for the degradation of antimicrobial agents, e.g., by P-lactamases (58 (25,39,40). However, the major criticism is that the most relevant information is the relative amount of drug in the interstitial fluid and cellular fluid (49).…”

Section: Introductionmentioning

confidence: 99%

Pulmonary disposition of antimicrobial agents: methodological considerations

Baldwin

Honeybourne

Wise

1992

Antimicrob Agents Chemother

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164

118

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“…In the present study, which was done by intravenous administration, obvious differences in the penetration of ELF were seen between GPFX and LVFX. Even in the other studies, GPFX concentrations in bronchial mucous significantly exceeded those achieved with ciprofloxacin (20) and temafloxacin (21). The GPFX concentration in the lung tissue in normal animals was 7 -10 times higher than that of serum level after intravenous administration (22,23).…”

Section: Discussionmentioning

confidence: 99%

Lung Tissue Distribution After Intravenous Administration of Grepafloxacin: Comparative Study With Levofloxacin

Yamamoto

Koizumi

Hirota

et al. 2002

Japanese Journal of Pharmacology

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ABSTRACT-The aim of the present study is to study the pharmacokinetics in plasma, lung lymph and bronchial washing fluid after intravenous infusion of grepafloxacin (GPFX), in comparison with those of levofloxacin (LVFX). Four conscious sheep with chronically instrumented lung lymph fistulas and tracheotomy were prepared. GPFX and LVFX concentrations in plasma and lung lymph after intravenous infusion of the drugs (10 mg / kg) for over 10 min were measured. In addition serial bronchial washing with 50 mL normal saline was performed to obtain epithelial lining fluid (ELF) at 2, 4, 6, 8, 12, 24 h after the intravenous administration. The time courses of lung lymph concentration were almost identical to those of the concomitant levels of both GPFX and LVFX in plasma, suggesting that both GPFX and LVFX could be easily moved from plasma to pulmonary interstitium and/ or lung lymph circulation. However, GPFX concentrations of ELF were significantly higher than LVFX concentrations over time after the administration. In addition, intracellular concentrations in ELF of GPFX were also extremely high compared with those of LVFX. These results demonstrated that penetration of GPFX in bronchial wall, bronchial epithelium and/or phagocytic cells was superior to that of LVFX. These observations suggest that the pharmacokinetic characteristics of GPFX in the lung may provide a new insight into the strategy for clinical treatment of various pulmonary infections, especially cytotropic bacterial infections.

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Evaluation of the penetration of ciprofloxacin and amoxycillin into the bronchial mucosa.

Abstract: 231 (84). This study has shown that the quinolone antibiotic ciprofloxacin is concentrated in the bronchial mucosa.

Cited by 63 publications

References 13 publications

Penetration of Meropenem into Pneumonic Human Lung Tissue as Measured by In Vivo Microdialysis

Penetration of Meropenem into Pneumonic Human Lung Tissue as Measured by In Vivo Microdialysis

Pulmonary disposition of antimicrobial agents: methodological considerations

Lung Tissue Distribution After Intravenous Administration of Grepafloxacin: Comparative Study With Levofloxacin

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