Evaluation of the Patient

Kagen, Lawrence J.

doi:10.1007/978-1-60327-827-0_1

Cited by 1 publication

(2 citation statements)

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“…The results, particularly the lower muscle stiffness measurements in IIM during the resting position across the lower limb muscles tested, support the face validity of SWE. The pathological mechanisms for this include the presence of destructive inflammatory infiltrates causing oedema and muscle atrophy [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…A methodology for evaluating SWE in normal muscle has recently been published [ 11 , 12 ]. We hypothesize that SWE could potentially be helpful for the investigation of muscles of patients with IIM, as the presence of inflammatory cells and exudate, thickened capillaries, peri-fascicular atrophy and myofiber necrosis [ 13 ] may result in an alteration of the mechanical properties of the tissue.…”

Section: Introductionmentioning

confidence: 99%

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Muscle shear wave elastography in idiopathic inflammatory myopathies: a case–control study with MRI correlation

et al. 2019

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Objective To investigate muscle stiffness in patients with idiopathic inflammatory myopathies (IIM) using shear wave elastography (SWE) and to correlate the results with muscle strength and MRI features of myositis. Materials and methods Muscle shear wave velocity (SWV) was measured in 23 active IIM patients (13 females, mean age 50.4 ± 16.1 years) and 23 matched healthy controls (13 females, mean age 50.7 ± 16.2 years). The investigated muscles included the vastus lateralis (VL), rectus femoris (RF), vastus medialis (VM) vastus intermedius (VI), biceps femoris (BF), semitendinosus (ST), semimembranosus (SM) and the biceps brachii (BB) scanned during relaxed resting and passive stretching positions. Participants performed multiple tests to evaluate their muscle strength. IIM patients had a thigh MRI to assess degrees of oedema, fatty infiltration and atrophy. Results In the resting position, IIM patients had a 12.9–22.2% significantly lower SWV ( p < 0.05) for the quadriceps and hamstrings, but not BB. There was no difference during passive stretching. The SWV for VL, VI and BF showed moderate correlations with the muscle strength tests ranging from r = 0.47 to r = 0.70 (all p < 0.05). Lower SWV was associated with greater MRI scores of oedema ( p = 0.001) and atrophy ( p = 0.006). However, SWV did not correlate with fatty infiltration ( r < 0.3; p = 0.28), creatine kinase ( r = 0.28; p = 0.19) or disease duration ( r = 0.26; p = 0.24). Conclusion Shear wave elastography may detect abnormal reduced thigh stiffness in IIM patients. SWE measurements were significantly associated with muscle weakness and MRI signs of oedema and atrophy. Future research should investigate this new technology for monitoring disease activity. Electronic supplementary material The online version of this article (10.1007/s00256-019-03175-3) contains supplementary material, which is available to authorized users

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Section: Discussionmentioning

confidence: 99%