Evaluation of the particle release of porous PMMA cements during curing

Beck, Stefan; Böger, Andreas

doi:10.1016/j.actbio.2009.04.002

Cited by 27 publications

(21 citation statements)

References 11 publications

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“…27-30 In a study by Beck and Boger, PMMA particulate release was observed to be greater for porous PMMA than for solid PMMA. 31 While these particulates may play a role in the remodeling process of the tissue surrounding the porous implants, the histological results from the present study indicate no difference, suggesting the effect of surface characteristics balances that of particulates.…”

Section: Discussioncontrasting

confidence: 57%

In situ formation of porous space maintainers in a composite tissue defect

Spicer

Kretlow

Henslee

et al. 2012

J Biomedical Materials Res

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Reconstruction of composite defects involving bone and soft tissue presents a significant clinical challenge. In the craniofacial complex, reconstruction of the soft and hard tissues is critical for both functional and aesthetic outcomes. Constructs for space maintenance provide a template for soft tissue regeneration, priming the wound bed for a definitive repair of the bone tissue with greater success. However, materials used clinically for space maintenance are subject to poor soft tissue integration, which can result in wound dehiscence. Porous materials in space maintenance applications have been previously shown to support soft tissue integration and to allow for drug release from the implant to further prepare the wound bed for definitive repair. This study evaluated solid and low porosity (16.9 ± 4.1%) polymethylmethacrylate space maintainers fabricated intraoperatively and implanted in a composite rabbit mandibular defect model for 12 weeks. The data analyses showed no difference in the solid and porous groups both histologically, evaluating the inflammatory response at the interface and within the pores of the implants, and grossly, observing the healing of soft tissue defect over the implant. These results demonstrate the potential of porous polymethylmethacrylate implants formed in situ for space maintenance in the craniofacial complex, which may have implications in the potential delivery of therapeutic drugs to prime the wound site for a definitive bone repair.

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Section: Discussioncontrasting

confidence: 57%

In situ formation of porous space maintainers in a composite tissue defect

Spicer

Kretlow

Henslee

et al. 2012

J Biomedical Materials Res

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show abstract

“…The invention of porous PMMA, in order to make regular PMMA cement more compliant with cancellous bone, while initially promising, remains questionable [70]. The risk of cement leakage can also be decreased by using viscoplastic bone cement due to its lower infiltration depth [71]. However, no direct indicators have been identified up to now that can predict cement leakage to prove superiority of the viscoplastic cement.…”

Section: Alternatives To Pmmamentioning

confidence: 99%

A Review of PMMA Bone Cement and Intra‐Cardiac Embolism

et al. 2016

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Percutaneous vertebroplasty procedure is of major importance, given the significantly increasing aging population and the higher number of orthopedic procedures related to vertebral compression fractures. Vertebroplasty is a complex technique involving the injection of polymethylmethacrylate (PMMA) into the compressed vertebral body for mechanical stabilization of the fracture. Our understanding and ability to modify these mechanisms through alterations in cement material is rapidly evolving. However, the rate of cardiac complications secondary to PMMA injection and subsequent cement leakage has increased with time. The following review considers the main effects of PMMA bone cement on the heart, and the extent of influence of the materials on cardiac embolism. Clinically, cement leakage results in life-threatening cardiac injury. The convolution of this outcome through an appropriate balance of complex material properties is highlighted via clinical case reports.

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“…Initially promising invention of porous PMMA, in order to make regular PMMA cement more compliant with cancellous bone, remains questionable [70]. The risk of cement leakage can also be decreased by using viscoplastic bone cement due to its lower infiltration depth [71]. However, no direct indicators have been identified till date to predict cement leakage to prove superiority of viscoplastic cement.…”

Section: Drug Delivery System Porous Pmma and Cementless Proceduresmentioning

confidence: 99%

A Review of PMMA Bone Cement and Intra-Cardiac Embolism

Shridhar¹,

Chen²,

Khalil³

et al. 2016

Preprint

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Percutaneous vertebroplasty procedure is of major importance, given the significant increasing aging population and higher number of orthopedic procedures related to vertebral compression fractures. Vertebroplasty is a complex technique involving injection of polymethylmethacrylate (PMMA) into the compressed vertebral body for mechanical stabilization of the fracture. Our understanding and ability to modify these mechanisms through alterations in cement material is rapidly evolving. However, the rate of cardiac complications secondary to PMMA injection and subsequent cement leakage has increased with time. The following review considers the main features of PMMA bone cement on the heart, and the extent of influence of materials on cardiac embolism. Clinically, cement leakage results in life-threatening cardiac injury. The convolution of this outcome through an appropriate balance of complex material properties is highlighted via clinical case report.

show abstract

Evaluation of the particle release of porous PMMA cements during curing

Cited by 27 publications

References 11 publications

In situ formation of porous space maintainers in a composite tissue defect

In situ formation of porous space maintainers in a composite tissue defect

A Review of PMMA Bone Cement and Intra‐Cardiac Embolism

A Review of PMMA Bone Cement and Intra-Cardiac Embolism

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