The purpose of the study was to investigate the effectiveness of rehabilitation measures in patients with severe gonarthrosis after total knee replacement based on quality of life assessment. Materials and methods. A total of 235 patients who underwent total knee replacement were examined and divided into 2 groups. The study group included 120 patients who completed a full course of comprehensive rehabilitation; the control group included 115 patients who underwent only a course of early postoperative rehabilitation followed by outpatient follow-up treatment without orthopedic control. To assess the quality of life, a system was used to determine the quality of life and the effectiveness of arthroplasty in patients after total knee replacement DGU 2020 0606. Results. A high level of quality of life in the study group was obtained in 87.5%, good – in 8.3%, and average – in 4.2% of patients. In the control group, these figures were 65.2%, 21.7%, and 11.3%, respectively. In addition, in this group, 1.8% of subjects with a low quality of life were identified. Conclusions. The use of the developed comprehensive approach to the rehabilitation of patients with severe gonarthrosis makes it possible to increase the number of the study group patients with a high quality of life by 22.3% and with a good quality of life by 12.7%, compared with the control group.