Evaluation of the osseointegration of dental implants coated with calcium carbonate: an animal study

Abstract

In an attempt to overcome the limitations of titanium in dental and orthopaedic clinical applications, a new method has been developed to prepare calcium carbonate coatings on sandblasted and acid-etched (SA) titanium implants. The purpose of this study was to investigate the effect of calcium carbonate-SA (CC-SA) implants on osseointegration in vivo. The surfaces of SA and CC-SA implants were characterised for surface morphology and surface chemistry. Subsequently, these two kinds of implants were implanted in the femoral condyles of rabbits. The implants were retrieved and prepared for histological and histomorphometric evaluation 1, 2, 4, 8 and 12 weeks after implantation. Significantly higher values of bone-to-implant contact of the entire implant except the gap area (BIC_ALL) and the bone-to-implant contact of the gap area (BIC_GAP) were found in animals with the CC-SA implants than in those with the SA implants at 4 weeks. Higher values of total gap bone were found in those with the CC-SA implants than in those with the SA implants at 1, 2 and 4 weeks. In conclusion, the current findings demonstrate that the calcium carbonate coating can improve and accelerate the early ingrowth of bone and osseointegration at the early healing phase. This may reduce clinical healing times and thus improve implant success rates.

Otoliths-composed gelatin/sodium alginate scaffolds for bone regeneration

“…OTL FTIR spectral data are characteristic of carbonate groups (CO 3 −2 ), with absorption bands located at 875 and 1400-1500 cm −1 . Intense bands can be observed at 1420 cm −1 , representing the anti-symmetrical stretching of the carbonyl of the carboxylate ion (C=O); at 858 cm −1 , related to the angular deformation of the CO 3 group; and at 708 cm −1 , characteristic of angular deformations in the O=C=O plane characteristic of CaCO 3 present in its structure in the form of aragonite [23]. A band was observed in 1080 cm −1 , related to the symmetrical stretch C=O, similar to the corresponding patterns of CaCO 3 in calcite forms (1080 cm −1 ) [24], and to the PO 4 3− found in calcium phosphate [25].…”

Non-Invasive Luciferase Imaging of Type I Interferon Induction in a Transgenic Mouse Model of Biomaterial Associated Bacterial Infections: Microbial Specificity and Inter-Bacterial Species Interactions

“…A critical factor in biofilm-related animal models remains the host immune system which in mice can easily kill the injected bacteria. Titanium is especially suitable as a material for dental implants as it is highly inert, biocompatible and resistant to the colonization by microorganisms [ 43 ]. Therefore, the important challenge to investigate bacterial infections on titanium implants in animal models remains the establishment of persistent infections with a much lower bacterial inoculum.…”

Trans-Endodontic Zirconium Oxide Implants: A Clinical Alternative

“…After these 60 days had elapsed, the authors removed the placed implant that had been set in place in order to histologically evaluate the presence of the osseointegration. Due to the nature of the study, the preservation of the dental organ is essential for the success of the trans-endodontic implant; thus, we could consider, as an aberration the removal of the dental organ, to check osseointegration (13). Therefore, different methods were employed to evaluate the osseointegration, such as dental mobility, the absence of an infectious process, together with rejection by the tissues and the presence of radio-opaque zones indicative of the formation of bone tissue around the implant.…”