Evaluation of the optic nerve head vessel density in patients with limited scleroderma

Hekimsoy, Hilal Kılınç; Şekeroğlu, Ali Mehmet; Hekimsoy, Vedat; Akdoğan, Ali

doi:10.1177/2515841421995387

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…Hekimsoy et al investigated OCT-A parameters of ONH and RNFL thickness using SD-OCT in patients with lcSSc. No significant differences were found in peripapillary vessel density and RNFL thickness in lcSSc patients compared with controls ( 54 ). This finding is consistent with our results, although dcSSc patients were not enrolled in the above-mentioned study.…”

Section: Discussionmentioning

confidence: 94%

Peripapillary choroidal vascularity index and thickness in patients with systemic sclerosis

Pieklarz,

Gińdzieńska-Sieśkiewicz,

Zawadzka

et al. 2023

Front. Med.

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IntroductionPatients with systemic sclerosis (SSc) present an increased risk of developing glaucomatous optic neuropathy (GON). We investigated peripapillary choroidal parameters and peripapillary retinal nerve fiber layer (RNFL) thickness using spectral domain optical coherence tomography (SD-OCT) to determine the relationships of these factors with clinical variables.MethodsA total of 33 patients with SSc were enrolled and compared to 40 controls. After obtaining circular scans around the optic disc, the global and quadrant peripapillary choroidal thickness (pCT) and RNFL thickness were measured. Additionally, the peripapillary choroidal vascularity index (pCVI), which allows for a quantitative analysis of the choroidal vasculature, was determined.ResultsNo significant differences were found in pCT and RNFL thickness between patients with SSc and controls, or within SSc subtypes (diffuse cutaneous systemic sclerosis (dcSSc) compared to limited cutaneous systemic sclerosis (lcSSc)) (p > 0.05). The pCVI was significantly lower in patients with SSc than in control subjects (64.25 ± 1.94 vs.65.73 ± 2.12, p < 0.001).ConclusionOur results suggest that the statistically significant decrease in pCVI in patients with SSc compared to the control group is probably due to a decrease in the vascular layer, which would partially explain an increased risk of GON in patients with SSc.

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Section: Discussionmentioning

confidence: 94%

Peripapillary choroidal vascularity index and thickness in patients with systemic sclerosis

Pieklarz,

Gińdzieńska-Sieśkiewicz,

Zawadzka

et al. 2023

Front. Med.

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Evaluation of the Effect of Levothyroxine Treatment on Ocular Vascular System in Patients with Hypothyroidism.

ÖNDER,

KOÇER,

ÖZDEMİR

et al. 2023

Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi

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Amaç: Sistemik vasküler değişikliklerin görülebildiği hipotiroidizm, tiroid hormonlarının yetersiz salgılanması ile karakterize endokrin sistem hastalığıdır. Bu çalışmada primer hipotiroidisi olan hastaların hipotiroid ve ötiroid dönemlerinde retina ve koroid vasküler değişikliklerinin kantitatif olarak optik koherens tomografi anjiografi (OKTA) ile incelenmesi amaçlandı. Gereç ve Yöntemler: Aşikar veya tedavi gerektiren subklinik hipotiroidisi olan 20 hastanın 40 gözü çalışmaya dahil edildi. Hastalar hipotiroid ve levotiroksin tedavisi sonrası ötiroid dönemde OKTA ile değerlendirildi. OKTA cihazı ile foveal avasküler zon (FAZ) ve koryokapillaris akım (KA) değerleri ile yüzeyel kapiller pleksus (YKP), derin kapiller pleksus (DKP)ve radyal peripapiller kapiller pleksus (RPKP) vasküler dansite verileri elde edildi. Bulgular: YKP, DKP ve RPKP vasküler dansite değerlerinde hipotiroid ve ötiroid dönemler arasında istatistiksel olarak anlamlı fark saptanmadı (tümü için p>0,05). 1,2 ve 3 mm tarama paternleri kullanılarak yapılan KA ölçümlerinde ise ötiroid dönemde hipotiroid döneme göre istatistiksel anlamlı artış görüldü (sırasıyla p=0,037; p=0,035; p=0,021). 1 ve 2 mm KA değerleri ötiroid dönemdeki sT4 düzeyleri ile pozitif korelasyon gösterirken (r=0,596; p< 0,001 ve r=0,402; p=0,012); 1 mm KA ölçümleri ile hasta yaşı ve ötiroid dönemdeki TSH düzeyleri arasında negatif korelasyon saptandı (r=-0,380; p= 0,016 ve r=-0,351; p=0,031). Sonuç: Bu çalışmada ötiroid dönemde hipotiroid dönemle karşılaştırıldığında artmış KA hızı saptanmıştır. Bu değişikliklerin hipotroidide görülebilen sistemik vasküler değişiklikler ile ilişkili olabileceği ve hipotroidi tanılı hastalarda olası vasküler etkilerin saptanmasında OKTA ile oküler akımın değerlendirilmesinin önemli olduğu düşünülmektedir.

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Connective tissue disorders and eye: A review and recent updates

Asif

Kalra

Sharma

et al. 2023

Indian Journal of Ophthalmology

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Collagen vascular disorders (CVDs), also known as connective tissue diseases (CTDs), are a heterogeneous group of entities that affect the connective tissues and are capable of causing end-organ damage to multiple systems, primarily cardiopulmonary and musculoskeletal. However, the occurrence and severity are highly variable among patients. Ocular involvement occurs in a significant number of these disorders and may precede the onset of other extraocular features, thereby serving as an important marker in the diagnosis of these diseases. A timely and accurate diagnosis enables the management of complications. CTDs are primarily immune-mediated inflammatory diseases; however, classifications have encompassed heritable disorders affecting collagen-containing structures and disorders of vascular development. A review of literature published until 25 January 2022 and collected from various databases using the relevant keywords was conducted. All publications (original articles, review articles, as well as case reports) describing the ocular features in CTDs were studied in detail. The objective of this review is to recognize the common ophthalmic presentations of various autoimmune and heritable CTDs, distinguish them from overlapping diseases, elaborate on the prognosis and management of these varied eye presentations, and deliberate on their impact on other ophthalmic surgeries.

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Evaluation of the optic nerve head vessel density in patients with limited scleroderma

Cited by 3 publications

References 19 publications

Peripapillary choroidal vascularity index and thickness in patients with systemic sclerosis

Peripapillary choroidal vascularity index and thickness in patients with systemic sclerosis

Evaluation of the Effect of Levothyroxine Treatment on Ocular Vascular System in Patients with Hypothyroidism.

Connective tissue disorders and eye: A review and recent updates

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