Evaluation of the nebulisation of sodium ceftiofur in the treatment of experimental Pasteurella haemolytica bronchopneumonia in calves

Sustronck, Bart; Deprez, Piet; Muylle, E.; Vermeersch, Hans; Vandenbossche, Geert; Remon, Jean‐Paul

doi:10.1016/0034-5288(95)90015-2

Cited by 18 publications

(19 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On day 0 at 22.00 (approximately six hours after journey), all calves were inoculated intratracheally with P. multocida. A first-pass culture of P. multocida was inoculated into 10 mL quantities of brain-heart-infusion broth (Oxoid), enriched with 5% fetal calf serum, and incubated at 37°C in a shaking water bath for six hours [7]. Afterwards, the approximate bacterial count of each broth was 5 × 10 9 cfu/mL.…”

Section: Experimental Infectionmentioning

confidence: 99%

“…A polyethylene tube (Intramedic, VEL) with an external diameter of 4.8 mm was inserted through the right nostril and advanced into trachea and the bronchial tree until an elastic resistance felt. Fifty mL of a sterile 0.9% solution of sodium chloride at 37°C was injected and aspirated immediately by genital suction; approximately 75% of the infused fluid could be retrieved [7]. The neutrophil/macrophage ratio was determined in the bronchoalveolar fluid.…”

Section: Bronchial Secretionsmentioning

confidence: 99%

“…All the samples were inoculated on three media: Colombia blood agar (Oxoid), PPLO agar (Difco) enriched with 25% inactivated horse serum, 7% yeast extract, 400 µg/ml ampicillin, 0.05% thallium acetate, and 1% glucose and Tween 80 PPLO agar (the same enriched and selective medium with 0.1 per cent Tween 80) [7]. The blood plates were evaluated after 24 or 48 h of incubation at 37°C in a carbon dioxide-enriched atmosphere.…”

Section: Bronchial Secretionsmentioning

confidence: 99%

“…secondary to other infections). Varieties of some species, including P. multocida and / or P. haemolytica could act as primary pathogens and would produce sever acute pneumonia in calves [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…The role of alveolar macrophages in the clearance of bacteria from lungs has attracted an interest [16]. Some of the antibiotics are accumulated in bronchial secretions and leukocytes and in turn, their penetration into the sub cellular compartments (lysosomes) would increase their clinical efficacies [7,16]. To guide effective therapy of pneumonia, this study was undertaken to investigate the disposition, distribution and the penetration pattern of florfenicol into respiratory tract secretions of clinically healthy and experimentally P. multocida-infected calves following i.v.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Pharmacokinetics and Distribution of Florfenicol in Bronchial Secretions of Healthy and Pasteurella multocida Infected Calves

Ramadan¹,

El‐Aty²

2011

Pharm Anal Acta

View full text Add to dashboard Cite

Florfenicol was administered intravenously and intramuscularly at a dose rate of 20 mg/kg bwt to determine its concentration in blood and bronchial secretions as well as kinetic behavior in healthy and diseased calves. Sever acute bronchopneumonia was induced via inoculating the animals with Pasteurella multocida. Following intravenous (i.v) administration, the serum concentration -time curve indicated a two compartment open model with a mean elimination half-lives (t 1/2β ) of 4.10 and 4.84 h in healthy and infected calves, respectively. The mean volumes of distribution at steady state (Vdss) were 0.68 and 0.63 L/kg and the total body clearances (C ltot ) were 0.15 and 0.11 L/kg/h with mean residence time (MRT) of 0.05 and 0.05 h, respectively. Florfenicol was slowly eliminated from serum and bronchial secretions with elimination half-lives (t 1/2el ) of (12.43 and 17.23 h) and (13.74 and 22.46 h), respectively, following intramuscular (i.m.) injection. The peak concentrations (Cmax) in serum and bronchial secretions were (3.70 and 4.06 µg/ml) and (6.88 and 7.62 µg/ml) attained at (3.07 and 3.01 h) and (1.54 and 1.70 h), respectively. The drug is extensively distributed to bronchial secretions with AUC bronchial secretion / AUC serum ratio of 1: 2.53 and 1: 2.03, respectively. The clinical and hematological parameters in calves treated intramuscularly returned to normal faster than those treated intravenously. These results suggest that i.m. injection of florfenicol could be used for treatment of acute P. multocida bronchopneumonia in calves.

show abstract

Section: Experimental Infectionmentioning

confidence: 99%

Section: Bronchial Secretionsmentioning

confidence: 99%

Section: Bronchial Secretionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Pharmacokinetics and Distribution of Florfenicol in Bronchial Secretions of Healthy and Pasteurella multocida Infected Calves

Ramadan¹,

El‐Aty²

2011

Pharm Anal Acta

View full text Add to dashboard Cite

show abstract

Assessment of nebulisation of sodium ceftiofur in the treatment of calves naturally infected with bovine respiratory disease

Joshi

Gupta

Dimri

et al. 2017

Trop Anim Health Prod

View full text Add to dashboard Cite

Twelve screened cases of bovine respiratory disease (BRD) in calves were enrolled. Six of the calves were treated intramuscularly with sodium ceftiofur (1 mg/kg), and six were treated with nebulised sodium ceftiofur (1 mg/kg). Comparative evaluation of the two therapeutic modalities was based on repetitive analysis of hematological profile of calves on days 0, 5, and 10 post-therapy. The mortality rate in the group of calves treated with the nebulised sodium ceftiofur was significantly (p < 0.001) lower, and their clinical and hematological parameters returned to normal significantly (p < 0.001) faster than in calves treated intramuscularly. Nebulisation of sodium ceftiofur is the most effective treatment in calves with BRD under field conditions. Nasal lavage fluid analysis indicating a high rise of neutrophil count and macrophages may be used as an alternative method to detect pulmonary inflammation in BRD-affected calves.

show abstract

Respiratory Diseases

Peek¹,

Ollivett²,

Divers³

2018

Rebhun's Diseases of Dairy Cattle

View full text Add to dashboard Cite

Evaluation of the nebulisation of sodium ceftiofur in the treatment of experimental Pasteurella haemolytica bronchopneumonia in calves

Cited by 18 publications

References 8 publications

Pharmacokinetics and Distribution of Florfenicol in Bronchial Secretions of Healthy and Pasteurella multocida Infected Calves

Pharmacokinetics and Distribution of Florfenicol in Bronchial Secretions of Healthy and Pasteurella multocida Infected Calves

Assessment of nebulisation of sodium ceftiofur in the treatment of calves naturally infected with bovine respiratory disease

Respiratory Diseases

Contact Info

Product

Resources

About