Evaluation of the myocardial venous blood oxygen level changes using MRI

Oellerich, W.F.; Li, D.; Haacke, E. Mark; Gropler, R.J.

doi:10.1016/s0735-1097(98)81360-0

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“…Different imaging methods have been proposed for noninvasive measurement of MBV, such as myocardial contrast echocardiography (26) and fast computed tomography (27). In our study, normal MBV at rest was measured from 99m Tc-labelled red blood cells as the standard of reference (23). After allowance was made for the difference between arterial (0.4) and capillary Hct (0.3) in the dogs (28), the resting value of global MBV was measured as 0.064 mL/g, or 6.4%.…”

Section: Discussionmentioning

confidence: 99%

Relationship of apparent myocardial T₂ and oxygenation: Towards quantification of myocardial oxygen extraction fraction

Zheng

Wang

Rowold

et al. 2004

Magnetic Resonance Imaging

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Purpose: To explore the relationship of myocardial T 2 and oxygenation for the quantification of myocardial oxygen extraction fraction (OEF). Materials and Methods:A proposed myocardial T 2 -OEF relationship was evaluated by computer simulation and in nine normal dogs in vivo. The relationship was based on a simplified two-compartment T 2 model. In the dogs, dipyridamole was infused intravenously to increase blood flow and change in myocardial oxygen content. The accuracy of the measurement in myocardial OEF in vivo by magnetic resonance imaging (MRI) was determined by arterial and coronary sinus blood sampling.Results: Global myocardial T 2 increased 16.1% from rest to the peak of dipyridamole-induced vasodilation (44.6 Ϯ 2.1 msec vs. 51.4 Ϯ 2.1 msec, P Ͻ 0.001). Corresponding OEF measured by arterial and venous (AV) sampling decreased from 0.64 Ϯ 0.15 at rest to 0.18 Ϯ 0.08 during the dipyridamole vasodilation, whereas OEF calculated by MRI at the peak effect of dipyridamole was 20 Ϯ 4%. Global myocardial OEF measured dynamically by MRI showed a strong correlation with OEF measured by blood sampling (correlation coefficient (CC) ϭ 0.83) during pharmacologic vasodilation. Conclusion:When combined with vasodilator stress, assessment of OEF may provide a putative measure of myocardial flow reserve, allowing consecutive monitoring of myocardial dose-responses to a variety of interventions and offering a new tool for the detection of coronary artery disease.

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Section: Discussionmentioning

confidence: 99%

Relationship of apparent myocardial T₂ and oxygenation: Towards quantification of myocardial oxygen extraction fraction

Zheng

Wang

Rowold

et al. 2004

Magnetic Resonance Imaging

View full text Add to dashboard Cite

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Evaluation of the myocardial venous blood oxygen level changes using MRI

Cited by 1 publication

References 0 publications

Relationship of apparent myocardial T₂ and oxygenation: Towards quantification of myocardial oxygen extraction fraction

Relationship of apparent myocardial T₂ and oxygenation: Towards quantification of myocardial oxygen extraction fraction

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Evaluation of the myocardial venous blood oxygen level changes using MRI

Cited by 1 publication

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Relationship of apparent myocardial T2 and oxygenation: Towards quantification of myocardial oxygen extraction fraction

Relationship of apparent myocardial T2 and oxygenation: Towards quantification of myocardial oxygen extraction fraction

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Relationship of apparent myocardial T₂ and oxygenation: Towards quantification of myocardial oxygen extraction fraction

Relationship of apparent myocardial T₂ and oxygenation: Towards quantification of myocardial oxygen extraction fraction