Evaluation of the mutagenicity of acetochlor to male rat germ cells

Ashby, John; Tinwell, H.; Lefevre, P.A.; Ja, Williams; Kier, Larry D.; Adler, I.‐D.; Clapp, M. J. L.

doi:10.1016/s1383-5718(97)00111-3

Cited by 18 publications

(10 citation statements)

References 23 publications

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“…However, after 30 days of exposure at the highest concentration (80 mg kg À1 ), acetochlor showed a high level of DNA damage to earthworm coelomocytes. Acetochlor caused no genotoxicity to the nasal cells of rats maintained on a diet containing the MTD (supra-maximum tolerated dose) for either one or 18 weeks (Ashby et al, 1997). Our experiment showed acetochlor has genetoxic effect on E. fetida after 30 days of exposure at 80 mg kg À1 soil.…”

Section: Discussionmentioning

confidence: 58%

Biomarkers responses of the earthworm Eisenia fetida to acetochlor exposure in OECD soil

Xiao

Song

et al. 2006

Chemosphere

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Section: Discussionmentioning

confidence: 58%

Biomarkers responses of the earthworm Eisenia fetida to acetochlor exposure in OECD soil

Xiao

Song

et al. 2006

Chemosphere

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“…2000). It was reported as non‐mutagenic to Salmonella , to the liver and nasal epithelium and germ cells of the rat (Ashby et al. 1996, 1997), when evaluated at the maximum tolerated dose (MTD, <1000 mg/kg).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of insecticidal and genotoxic effects of imidacloprid and acetochlor in Drosophila melanogaster

Frantzios

Paptsiki

Sidiropoulou

et al. 2008

J Applied Entomology

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Two pesticides, the insecticide imidacloprid and the herbicide acetochlor, were evaluated for their insecticidal and genotoxic effects in Drosophila melanogaster. Their insecticidal effects were assessed by calculating LC50 values after acute or chronic exposure of larvae and adults to different concentrations of the test compounds. After acute exposure, the LC50 of imidacloprid was 7.59 × 10−5 M for larvae and 1.43 × 10−4 M for adults, and after chronic exposure, it was 2.67 × 10−5 M and 6.09 × 10−5 M for larvae and adults, respectively. On the contrary, the herbicide acetochlor showed no acute or chronic insecticidal effect against either larvae or adults, even at very high concentrations (8 × 10−3 M). For the evaluation of genotoxic properties of the two pesticides, the Somatic Mutation and Recombination Test in D. melanogaster was used. Our results suggest that neither imidacloprid nor acetochlor exhibits mutagenic or recombinogenic activity at applicable concentrations.

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“…), mutagenizing germ cells of male rats (Ashby et al . ) and altering thyroid hormone‐dependent gene expression in Xenopus laevis (Crump et al . ).…”

Section: Introductionmentioning

confidence: 99%

Degradation of acetochlor by a bacterial consortium of Rhodococcus sp.T3-1, Delftia sp.T3-6 and Sphingobium sp.MEA3-1

Hou

Dong

Wang

et al. 2014

Lett Appl Microbiol

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Significance and Impact of the Study: This study presents a bacterial consortium consisting of Rhodococcus sp.T3-1, Delftia sp.T3-6 and Sphingobium sp.MEA3-1 could completely mineralize acetochlor by biochemical cooperation. The study reveals the metabolic mechanism of acetochlor biodegradation and highlights the potential of the bacterial consortium for cleaning up acetochlor and its metabolites subsisting in the environment. AbstractOwing to acetochlor persistence in the environment and its perceptible threats to the ecosystem and human health, it is urgent to search for effective approaches to decontaminate acetochlor. In this study, an acetochlor-degrading enrichment culture was obtained by continuous enrichment from acetochlorcontaminated soil and named T3. T3 could completely degrade 100 mg l À1 acetochlor and butachlor within 6 days. Two bacterial strains Rhodococcus sp.T3-1 and Delftia sp.T3-6 and one strain Sphingobium sp.MEA3-1 were isolated and identified from T3 by using acetochlor and MEA as sole carbon source, respectively. These three bacteria could completely mineralize acetochlor by the cooperative metabolism. The biochemical pathway of acetochlor degradation by these three bacteria in a consortium was proposed: acetochlor to 2 0 -methyl-6 0 -ethyl-2-chloroacetanilide (CMEPA) by Rhodococcus sp. T3-1, CMEPA to 2-methyl-6-ethyl aniline (MEA) by Delftia sp.T3-6 and MEA by Sphingobium sp.MEA3-1 based on the identified degradation intermediates. Under laboratory conditions, the consortium was effective in the acetochlor mineralization.

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Evaluation of the mutagenicity of acetochlor to male rat germ cells

Cited by 18 publications

References 23 publications

Biomarkers responses of the earthworm Eisenia fetida to acetochlor exposure in OECD soil

Biomarkers responses of the earthworm Eisenia fetida to acetochlor exposure in OECD soil

Evaluation of insecticidal and genotoxic effects of imidacloprid and acetochlor in Drosophila melanogaster

Degradation of acetochlor by a bacterial consortium of Rhodococcus sp.T3-1, Delftia sp.T3-6 and Sphingobium sp.MEA3-1

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