Evaluation of the mechanical properties and drug release of cross-linked Eudragit films containing metronidazole

Adhesive properties: a critical issue in transdermal patch development

“…To counterbalance the unpredictable effects caused by active ingredients, the possibility to modify adhesiveness by changing ratios among polymeric components as well as between plasticizer and tackifier was also investigated [44,48,82,83]. The effects of triacetin on adhesion strength of PAMA-based PSA were investigated [84]. Triacetin or citric acid ester resulted suitable to modulate the properties of a poly(methylmethacrylate ethylacrylate)-based PSA, which were altered by active ingredients, such as nicotine or diclofenac [48].…”

“…When isopropyl myristate was introduced into a siliconbased PSA to enhance the drug permeation, the matrix flew easily favoring the rapid wetting of skin, which increased the Active ingredient Piroxicam Acrylates Peel adhesion Reduction [44] Coumarin Acrylates Peel adhesion none [20] Captopril ethyl esters Acrylates Tack Increase up 13.3%, then decrease [79] Miconazole Acrylates Peel adhesion Reduction [80] Miconazole Acrylates Shear adhesion Reduction [17] Benztropine Acrylates Peel adhesion Increase [81] Acrylates Tack Reduction Acrylates Shear adhesion Reduction Nicotine Acrylates Peel adhesion Increase [48] Shear adhesion Reduction Diclofenac Acrylates Peel adhesion Reduction [48] Shear adhesion Reduction Plasticizer PEG 200 Acrylates Peel adhesion Increase [82] Propylene glycol Acrylates Peel adhesion Increase [82] Diethyl phthalate Acrylates Peel adhesion Increase [82] Triacetin Acrylates Peel adhesion Increase [84] Triacetin Acrylates Tack Increase [48] Shear adhesion Increase Tributhylcitrate Acrylates Tack Increase [48] Shear adhesion Increase Propylene glycol Acrylates Peel adhesion None [87] Glycerin and/or PEG Acrylate/water Tack Increase [29] Sorbitol Acrylate/water Tack None [29] Acrylate/water Shear adhesion Increase [29] PEG Acrylate/water Shear adhesion Decrease [29] Glycerin Acrylate/water Shear adhesion None [29] Glycerin Gelatine/acrylate Peel adhesion None [83] Propylene glycol Gelatine/acrylate Peel adhesion Increase [83] Skin penetration Isopropyl myristate Silicon Peel adhesion Increase [85] Enhancer Shear adhesion Decrease Isopropyl myristate Acrylate Shear adhesion Decrease [82] Isopropyl myristate Acrylate Peel adhesion Decrease [85] Oleic acid Acrylate Peel adhesion Increase [44] Oleic acid Acrylate Peel adhesion Decrease [86,87] Azone Ò acrylate/PVA Peel adhesion Decrease [57] Sodium lauryl sulfate Polyisobutylenes Peel adhesion Decrease [88] DMSO Polyisobutylenes Peel adhesion Decrease …”

Dispositivo implantável de EUDRAGIR/PCL-T/ Diclofenaco de sódio: caracterização mecânica, liberação do fármaco e atividade anti-inflamatóriain vivo

“…Although they are good candidates for the production of films, they are quite hard and require plasticizers to improve their mechanical properties. 22 Figure 2 shows the stress-strain curves obtained from DMA analysis at 37 o C form EUDPCL-T and EUD/PCL-T/Diclofenac devices measuring 11 mm x 1 mm.…”

Plasticizers in Transdermal Drug Delivery Systems

“…Increase in the mobility of the polymer chains and corresponding decrease in the crystallized area existing within the polymer are expected to enhance the active substance permeation. It has been concluded that, best cohesion promoter-plasticizer combination for Eudragit E 100 films was 7% succinic acid and 25% or 45% triacetine (Elgindy & Samy, 2009). …”