Evaluation of the Mean Platelet Volume in Children with Juvenile Idiopathic Arthritis

Abstract

Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory arthritis in children. Mean platelet volume (MPV) is an indicator of platelet size and has been investigated as an inflammation marker in several diseases MPV, ESR, and CRP in the JIA group (r=0.676, p<0.001 and r=0.430, p<0.006). In addition, a negative correlation was found between platelet count and MPV (r= -0.818, p<0.001

Thyroid Disorders in Juvenile Idiopathic Arthritis Patients and Its Correlation with Disease Activity: A Cross-Sectional Study

“…This comes in agreement with Unsal et al [23] and Özdoğan et al [30] who found a predominance of males among JIA patients. On the contrary, many studies reported a higher incidence of JIA in females than males [31,32] . This was explained by Thierry et al [28] who concluded that incidence and prevalence vary greatly most probably due to methodological issues, classification used, and time of diagnosis.…”

“…In agreement with our study, some studies stated that JIA can be associated with growth retardation due to pro-inflammatory cytokines such as IL-6, long-term corticosteroid therapy, malnutrition, and stress (linked to having a chronic illness or disability) [33,34] . In the study done by Sen et al [32] , the most prevalent early-presenting symptoms were arthralgia in 98.1%, fever in 52.1%, fatigue in 39.9%, malaise in 53.5%, and morning stiffness in 15.5%. However, this contradicts Al-Hemairi et al [24] who reported that fever was present in 41.46% of JIA patients.…”

“…On the contrary, Abdwani et al [26] reported that non-steroidal anti-inflammatory drugs (NSAIDs) were the most used drugs in 97% of patients, followed by steroids, methotrexate, and biologic agents in 74%, 61%, and 34% respectively. Also, Sen et al [32] reported that NSAIDs were the most frequently used drugs (89.2%), followed by methotrexate (71.4%) and steroids (37.6%).…”