Evaluation of the material properties of the subsynovial connective tissue in carpal tunnel syndrome

Osamura, Naoki; Zhao, Chunfeng; Zobitz, Mark E.; An, Kai Nan; Amadio, Peter C.

doi:10.1016/j.clinbiomech.2007.07.009

Cited by 59 publications

(60 citation statements)

References 17 publications

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“…Although the clinical aspect of this disease has been well studied, its cause remains unknown 8,9 . Changes in mechanical properties and fibrosis of the subsynovial connective tissue within the carpal tunnel are the major pathological findings in patients with carpal tunnel syndrome 10,11 . Although these changes may hinder mediannerve gliding 12 and lead to elevated local strains and pressures, so far there is no way to diagnose the cause of this condition.…”

mentioning

confidence: 99%

Ultrasound Assessment of the Displacement and Deformation of the Median Nerve in the Human Carpal Tunnel with Active Finger Motion

Yoshii

Villarraga

Henderson

et al. 2009

The Journal of Bone and Joint Surgery-American Volume

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115

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confidence: 99%

Ultrasound Assessment of the Displacement and Deformation of the Median Nerve in the Human Carpal Tunnel with Active Finger Motion

Yoshii

Villarraga

Henderson

et al. 2009

The Journal of Bone and Joint Surgery-American Volume

Self Cite

115

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“…[6] This phenomenon results in a vicious cycle of increased shearing force throughout SSCT because fibrosis increases both the stiffness of the tissue and shearing modulus that inevitably result in shearing force to be much more effective. [7,8] Fibroblasts are effective mechano-responsive cells. [9] It is shown that fibroblasts respond to tension, compression and shearing forces with expression of different genes, and they can even change their phenotype to more fibrotic cells such as myofibroblasts.…”

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confidence: 99%

Are myofibroblasts activated in idiopathic carpal tunnel syndrome? An immunohistochemical study

Yeşìl¹

2014

Eklem Hastalik Cerrahisi

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Amaç: Bu çalışmada miyofibroblastların idiopatik karpal tünel sendromundaki (KTS) fibrotik süreçte rol oynayıp oynamadığı araştırıldı. Hastalar ve yöntemler: Mart 2010-Ağustos 2010 tarihleri arasında kliniğimizde ameliyat edilen 40 hasta (12 erkek, 28 kadın; ort. yaş 50.85±11.2 yıl; dağılım 30-71 yıl) çalışmaya alındı. Yirmi beş idiopatik KTS hastası çalışma grubuna, 15 travma hastası kontrol grubuna dahil edildi. Katılımcıların hem transvers karpal ligaman hem de subsinovyal bağ dokusundan (SSBD) örnekler alındı ve bunlar immünohistokimyasal yöntem ile analiz edildi. Miyofibroblast varlığını ve damar duvar kalınlığını (alfa düz kas aktin [a-DKA]), kollajen tip IV antikorları, T (CD3) ve B (CD20) lenfositleri incelemek için dört immünohistokimyasal işaretleyici kullanıldı. Bulgular: İdiopatik KTS'nin erken aşamasında olan hastaların SSBD'sinde miyofibroblast varlığı (a-DKA) antikorlarının fibroblastlar ile pozitif reaksiyonu yoluyla gösterildi. Subsinovyal bağ dokusunun vasküler yapısında a-DKA ve kollajen antikor reaksiyonunun anlamlı şekilde artmış olması, çalışma grubunda damar duvar kalınlığı ve vaskülaritenin artmış olduğunu gösterdi (p<0.01). İki grup arasında T ve B lenfosit antikor reaksiyonu açısından anlamlı fark saptanmadı (inflamasyon). Sonuç: Bu çalışmanın bulguları, miyofibroblastların hastalığın erken döneminde aktifleşip hastalığın başlangıcına katkı yapma olasılıkları olduğuna işaret etmektedir. İleride yapılacak daha büyük örneklem sayılı çalışmalar miyofibroblastların idiopatik KTS'deki rolünün anlaşılmasına büyük katkı sağlayacaktır.Anahtar sözcükler: Karpal; fibrozis; idiopatik; miyofibroblast; sendrom.Objectives: This study aims to investigate whether myofibroblasts participate in the fibrotic process of idiopathic carpal tunnel syndrome (CTS). Patients and methods: Forty patients (12 males, 28 females; median age 50.85±11.2 years; range 30 to 71 years) who were operated in our clinic between March 2010 and August 2010 were included in the study. Twenty-five idiopathic CTS patients were assigned to the study group, and 15 trauma patients were assigned to the control group. Samples were taken from both transverse carpal ligament and subsynovial connective tissue (SSCT) of participants and they were analyzed by immunohistochemical method. Four immunohistochemical markers were used to analyze myofibroblast existence and vascular wall thickness (alpha smooth muscle actin [a-SMA]), collagen type IV antibodies, and T (CD3) and B (CD20) lymphocytes. Results: The existence of myofibroblasts (a-SMA) in SSCT of patients who were in early phase of idiopathic CTS was shown through the positive reaction of their antibodies with fibroblasts. A significantly increased reaction of a-SMA and collagen antibodies in vascular structure of SSCT demonstrated increased vascular wall thickness and vascularity in the study group (p<0.01). No significant difference was detected between the two groups in terms of T and B lymphocyte antibody reaction (inflammation). Conclusion: The findings of this study indicate a po...

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“…Some studies have investigated the fibrosis of the subsynovial connective tissue (SSCT) encasing the flexor tendons as a contributing factor in the etiology of primary CTS. [3][4][5][6] In 2004, Ettema et al demonstrated marked proliferation and fibrosis of the SSCT in patients with established primary CTS. It was suggested that this resulted in increased carpal tunnel pressures that could give rise to CTS.…”

Section: Introductionmentioning

confidence: 98%

Biphasic Motion of the Median Nerve in the Normal Asian Population

2015

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Evaluation of the material properties of the subsynovial connective tissue in carpal tunnel syndrome

Abstract: Background: The purpose of this study was to determine the material properties of the normal carpal tunnel subsynovial connective tissue in response to shear stress.

Cited by 59 publications

References 17 publications

Ultrasound Assessment of the Displacement and Deformation of the Median Nerve in the Human Carpal Tunnel with Active Finger Motion

Ultrasound Assessment of the Displacement and Deformation of the Median Nerve in the Human Carpal Tunnel with Active Finger Motion

Are myofibroblasts activated in idiopathic carpal tunnel syndrome? An immunohistochemical study

Biphasic Motion of the Median Nerve in the Normal Asian Population

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