Evaluation of the Maquet Neonatal and Pediatric Quadrox I with an integrated arterial line filter during cardiopulmonary bypass

Melchior, Richard; Schiavo, Kellie L.; Frey, T; Rogers, David A.; Patel, Jyoti K.; Chelnik, K; Rosenthal, Tami

doi:10.1177/0267659112450059

Cited by 13 publications

(10 citation statements)

References 15 publications

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“…Therefore, using this set‐up, it is necessary to monitor the real flow rate to the patient to prevent systemic hypoperfusion during CPB . An alternative method is using an oxygenator with an integrated arterial filter, which still captures more GME and reduces priming volume .…”

Section: Discussionmentioning

confidence: 99%

In Vitro Evaluation of Pediatric Hollow-Fiber Membrane Oxygenators on Hemodynamic Performance and Gaseous Microemboli Handling: An International Multicenter/Multidisciplinary Approach

et al. 2017

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The objective of this study was to compare the hemodynamic performances and gaseous microemboli (GME) handling ability of two pediatric oxygenators in a simulated pediatric cardiopulmonary bypass (CPB) model and the importance of adding an arterial filter in the circuit. The circuit consisted of a Braile Infant oxygenator or a Maquet Quadrox-I Pediatric oxygenator without integrated arterial filter (parallel arrangement), 1/4 in. ID tubing A-V loop, and a 12-Fr arterial cannula, primed with lactated Ringer's solution and packed red blood cells. Trials were conducted at flow rates ranging from 500 to 2000 mL/min (500 mL/min increment) at 35°C and 28°C. Real-time pressure and flow data were recorded using a custom-based data acquisition system. For GME testing, 5 cc of air was manually injected into the venous line. GME were recorded using the Emboli Detection and Classification Quantifier (EDAC) System. An additional experiment using a separate arterial filter was conducted. There was no difference in the mean circuit pressure, pressure drop, total hemodynamic energy level, and energy loss between the two oxygenators. The venous line pressures were higher in the Braile than in the Quadrox group during all trials (P <0.01). GME count and volume at pre-/post oxygenator and pre-cannula sites in the Quadrox were lower than the Braile group at high flow rates (P < 0.05). In the additional experiment, an arterial filter captured a significant number of microemboli at all flow rates. The Braile Infant oxygenator has a matched hemodynamic characteristic with the Quadrox-i Pediatric oxygenator. The Quadrox-i has a better GME handling ability compared with the Braile Infant oxygenator. Regardless of type of oxygenator an additional arterial filter decreases the number of GME.

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Section: Discussionmentioning

confidence: 99%

In Vitro Evaluation of Pediatric Hollow-Fiber Membrane Oxygenators on Hemodynamic Performance and Gaseous Microemboli Handling: An International Multicenter/Multidisciplinary Approach

et al. 2017

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“…The stacked membrane design had a square structure that was different than many of the models from the previous 15 years of pediatric oxygenator design. 61 This product was shown clinically to reduce the membrane pressure gradient 62 and to provide gaseous microemboli protection. 63 …”

Section: Modern Era Of Pediatric Hollow Fiber Membrane Oxygenator Tecmentioning

confidence: 99%

Evolution of membrane oxygenator technology for utilization during pediatric cardiopulmonary bypass

Melchior

Sutton²,

Harris

et al. 2016

PHMT

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The development of the membrane oxygenator for pediatric cardiopulmonary bypass has been an incorporation of ideology and technological advancements with contributions by many investigators throughout the past two centuries. With the pursuit of this technological achievement, the ability to care for mankind in the areas of cardiac surgery has been made possible. Heart disease can affect anyone within the general population, but one such segment that it can affect from inception includes children. Currently, congenital heart defects are the most common birth defects nationally and worldwide. A large meta-analysis study from 1930 to 2010 was conducted in review of published medical literature totaling 114 papers with a study population of 24,091,867 live births, and divulged a staggering incidence of congenital heart disease involving 164,396 subjects with diverse cardiac illnesses. The prevalence of these diseases increased from 0.6 per 1,000 live births from 1930–1934 to 9.1 per 1,000 live births after 1995. These data reveal an emphasis on a growing public health issue regarding congenital heart disease. This discovery displays a need for heightened awareness in the scientific and medical industrial community to accelerate investigative research on emerging cardiovascular devices in an effort to confront congenital anomalies. One such device that has evolved over the past several decades is the pediatric membrane oxygenator. The pediatric membrane oxygenator, in conjunction with the heart lung machine, assists in the repair of most congenital cardiac defects. Numerous children born with congenital heart disease with or without congestive heart failure have experienced improved clinical outcomes in quality of life, survival, and mortality as a result of the inclusion of this technology during their cardiac surgical procedure. The purpose of this review is to report a summary of the published medical and scientific literature related to development of the pediatric membrane oxygenator from its conceptual evolutionary stages to artificially supporting whole body perfusion in the modern pediatric cardiac surgical setting.

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“…[11][12][13][14][15] In addition, hollow-fiber membrane oxygenators can trap the majority of GME in the CPB circuit; novel hollow-fiber membrane oxygenators with integrated arterial filters not only reduce the priming volume, but also capture most of the GME. 12,13,16,17 Any component in the CPB circuit should be tested in vitro and in vivo before it is used in clinical practice. The present study was to compare the Sorin KIDS D131 and the Terumo Capiox AF02 pediatric arterial filters' ability to filter out GME and the filters' overall proficiency, using human blood during a simulated pediatric CPB procedure.…”

Section: Introductionmentioning

confidence: 99%

Handling ability of gaseous microemboli of two pediatric arterial filters in a simulated CPB model

et al. 2013

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Evaluation of the Maquet Neonatal and Pediatric Quadrox I with an integrated arterial line filter during cardiopulmonary bypass

Cited by 13 publications

References 15 publications

In Vitro Evaluation of Pediatric Hollow-Fiber Membrane Oxygenators on Hemodynamic Performance and Gaseous Microemboli Handling: An International Multicenter/Multidisciplinary Approach

In Vitro Evaluation of Pediatric Hollow-Fiber Membrane Oxygenators on Hemodynamic Performance and Gaseous Microemboli Handling: An International Multicenter/Multidisciplinary Approach

Evolution of membrane oxygenator technology for utilization during pediatric cardiopulmonary bypass

Handling ability of gaseous microemboli of two pediatric arterial filters in a simulated CPB model

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