Evaluation of the left ventricular regional function using two-dimensional speckle tracking echocardiography in patients with end-stage renal disease with preserved left ventricular ejection fraction

Altekin, Refi K Emre; Küçük, Murathan; Yanıkoğlu, Atakan; Karakaş, Mustafa Serkan; Er, Arzu; Özel, Deniz; Ermis, Cengiz; Demir, İbrahim

doi:10.1080/ac.67.6.2184671

Cited by 13 publications

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“…Even though decreases in longitudinal and radial systolic function have been reported in patients with ESRD, their LVEF may remain within normal range through preserved circumferential function. 2D speckle-tracking echocardiography has also been used to assess the severity of uremic cardiomyopathy during the early stages of the disease, and it may also be useful in patients with ESRD and preserved LVEF [40].…”

Section: ) Association Between Gls and CV Outcomesmentioning

confidence: 99%

“…In addition, 2D speckle-tracking echocardiography has also been used to differentiate between active and passive myocardial motion to allow for the 2D angle-independent quantification of myocardial deformation, which can more accurately reflect the systolic and diastolic performance of all myocardial segments. GLS, which can be measured from 2D speckle-tracking echocardiography, is a novel method that has recently been used to assess systolic LV function [39], and less negative GLS has been reported to be associated with an increased risk of mortality in patients undergoing HD [40].…”

Section: Global LV Longitudinal Systolic Strain (Gls)mentioning

confidence: 99%

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Prognostic Cardiovascular Markers in Chronic Kidney Disease

Chen

Huang

et al. 2018

Kidney Blood Press Res

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Chronic kidney disease (CKD), including end-stage renal disease (ESRD), is a public health issue worldwide, and is associated with high rates of morbidity and mortality. In addition, cardiovascular disease is a major cause of mortality in these patients. Both traditional and nontraditional risk factors associated with CKD can lead to remodeling of the myocardium and blood vessels, thereby resulting in cardiomyopathy, atherosclerosis and arterial stiffness. This can subsequently lead to ischemic heart disease, heart failure, cardiovascular death, rapid renal progression and progression to ESRD. Identifying these risk factors to allow for aggressive preventive and interventional strategies is important for the management of patients with CKD. This aim of this review was to survey the clinical outcomes of CKD using cardiac and vascular markers including echocardiographic parameters, systolic time intervals, electrocardiography, heart rate variability, ankle-brachial index, pulse wave velocity, differences between interarm and interankle blood pressure, and vascular calcification.

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Section: ) Association Between Gls and CV Outcomesmentioning

confidence: 99%

Section: Global LV Longitudinal Systolic Strain (Gls)mentioning

confidence: 99%

Prognostic Cardiovascular Markers in Chronic Kidney Disease

Chen

Huang

et al. 2018

Kidney Blood Press Res

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“…Other authors also reported LV ejection fractions that were in the normal range, but significantly lower than control, whereas other authors did not report such findings . However, altered systolic function may be detected by exercise echocardiography or strain using speckle tracking in CKD children on dialysis, despite the finding of a preserved ejection fraction …”

Section: Discussionmentioning

confidence: 93%

Children with Chronic Renal Disease Undergoing Dialysis or Conservative Treatment–Differences in Structural and Functional Echocardiographic Parameters

et al. 2014

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“…Although longitudinal and radial systolic functions are decreased in patients with ESRD, LVEF may remain within normal limits due to the preservation of circumferential function. 2D speckle-tracking echocardiography may be able to detect the severity of uremic cardiomyopathy in the early stages of disease, it may also be able to provide useful information for assessing risk in patients with ESRD with preserved LVEF [44]. Therefore, the use of GLS in maintenance HD patients may help to identify those at a high risk of poor outcomes.…”

Section: Discussionmentioning

confidence: 99%

Independent Association of Overhydration with All-Cause and Cardiovascular Mortality Adjusted for Global Left Ventricular Longitudinal Systolic Strain and E/E’ Ratio in Maintenance Hemodialysis Patients

Huang

Tsai

et al. 2018

Kidney Blood Press Res

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Background/Aims: Fluid overload is common and associated with morbidity and mortality in patients with end-stage renal disease. The relationship between fluid overload and cardiac function is complex, and whether fluid overload is associated with adverse outcomes in patients undergoing hemodialysis (HD) independently of systolic and diastolic function of the left ventricle (LV) remains unclear. Methods: The present study aimed to investigate the relationship between overhydration and all-cause and cardiovascular (CV) mortality after adjusting for LV function in 178 maintenance HD patients. The relative hydration status (overhydration/ extracellular water, ∆HS) was measured using a body composition monitor, and then used to assess the fluid status. A ∆HS ≥7% was defined as fluid overload. Global left ventricular longitudinal systolic strain (GLS), and the early filling and early diastolic mitral annular velocity (E/E’) ratio were assessed using speckle-tracking and tissue Doppler echocardiography. Results: During a mean follow-up period of 2.7 years, 24 patients died, including 11 CV deaths. An increased ∆HS was significantly associated with all-cause and CV mortality in the univariate analysis. This prognostic significance remains after multivariate adjusting for GLS and E/E’ ratio for all-cause (HR, 1.123; 95% CI, 1.063–1.186; p-value < 0.001) and CV (HR, 1.088; 95% CI, 1.005–1.178; p-value =0.037) mortality. Moreover, ∆HS significantly improved the prognostic value beyond conventional clinical and echocardiographic parameters. Conclusion: A higher ∆HS was independently associated with increased all-cause and CV mortality after adjusting for systolic and diastolic function of the LV. This suggests that ∆HS may be a relevant target for improving outcomes in maintenance HD patients.

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Evaluation of the left ventricular regional function using two-dimensional speckle tracking echocardiography in patients with end-stage renal disease with preserved left ventricular ejection fraction

Cited by 13 publications

References 0 publications

Prognostic Cardiovascular Markers in Chronic Kidney Disease

Prognostic Cardiovascular Markers in Chronic Kidney Disease

Children with Chronic Renal Disease Undergoing Dialysis or Conservative Treatment–Differences in Structural and Functional Echocardiographic Parameters

Independent Association of Overhydration with All-Cause and Cardiovascular Mortality Adjusted for Global Left Ventricular Longitudinal Systolic Strain and E/E’ Ratio in Maintenance Hemodialysis Patients

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