Evaluation of the Isoflavone Genistein as Reversible Human Monoamine Oxidase‐A and ‐B Inhibitor

Zarmouh, Najla O.; Messeha, Samia S.; Elshami, Faisel M.; Soliman, Karam F.A.

doi:10.1155/2016/1423052

Cited by 34 publications

(22 citation statements)

References 53 publications

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“…Zarmouh and co-workers [ 35 ] in their recent work described the inhibitory properties of an isoflavone—genistein in a bioluminescence assay. In their studies this compound at a concentration of 9.7 µM achieved 50% inhibition.…”

Section: Resultsmentioning

confidence: 99%

MAO-A Inhibitory Potential of Terpene Constituents from Ginger Rhizomes—A Bioactivity Guided Fractionation

et al. 2018

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Background: In the search for novel antidepressive drug candidates, bioguided fractionation of nonpolar constituents present in the oleoresin from ginger rhizomes (Zingiber officinale Roscoe, Zingiberaceae) was performed. This particular direction of the research was chosen due to the existing reports on the antidepressive properties of ginger total extract. The search for individual metabolites acting as MAO-A inhibitors, which correspond to the apparent effect of the total extract, is the subject of this work. Methods: Hexane extracts from ginger rhizomes were fractionated by using column chromatography (including silica gel impregnated with silver nitrate) and semi-preparative high-performance chromatography. For the activity assessment, an in vitro monoamine oxidase A (MAO-A) inhibition luminescence assay was performed on 10 purified terpenes: 1,8-cineole, α-citronellal, geraniol, β-sesquiphellandrene, γ-terpinen, geranyl acetate, isobornyl acetate, terpinen-4-ol, (E,E)-α-farnesene, and α-zingiberene. Results: Geraniol and (−)-terpinen-4-ol were found to be the strongest enzyme inhibitors with inhibition of 44.1% and 42.5%, respectively, at a concentration of 125 µg/mL. No differences in the inhibition potential were observed for the different groups of terpenes: sesquiterpenes, monoterpenes, or sesquiterpene alcohols; however, the two most active compounds contained a hydroxyl moiety. Conclusions: Terpene constituents from ginger’s extract were found to exhibit moderate inhibitory properties against the MAO-A enzyme in in vitro tests.

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Section: Resultsmentioning

confidence: 99%

MAO-A Inhibitory Potential of Terpene Constituents from Ginger Rhizomes—A Bioactivity Guided Fractionation

et al. 2018

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“…Ellagic acid [214] Entacapone (Comtan, ASI-6) [12,215,216] Enzastaurin [164] Epicatechin [128,160,193,194] Epigallocatechin-3-gallate [117,217,218] Etidronate (HEDPA) [219] Exifone [12] F13714 [220] F15599 [220,221] Farrerol [222] Fisetin (3,3 ,4 ,7-Tetrahydroxy flavone) [223][224][225] Fraxetin [117] Galangin [226] Gallic acid and derivatives [214,227,228] Gallocatechin [128] Garcinol [229] Genistein [117,128,230,231] Glutamine [232] Glutathione derivatives [63] Glutathione -hydroxyquinoline compound [233] Glutathione-l-DOPA compound [234] Gly-N-C-DOPA [209] GSK2795039 [108] Guanabenz [235] Hesperidin [128,236] Hinokitiol […”

Section: Compound Name(s) Referencesmentioning

confidence: 99%

Metal Chelation Therapy and Parkinson’s Disease: A Critical Review on the Thermodynamics of Complex Formation between Relevant Metal Ions and Promising or Established Drugs

Tosato

Marco

2019

Biomolecules

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The present review reports a list of approximately 800 compounds which have been used, tested or proposed for Parkinson’s disease (PD) therapy in the year range 2014–2019 (April): name(s), chemical structure and references are given. Among these compounds, approximately 250 have possible or established metal-chelating properties towards Cu(II), Cu(I), Fe(III), Fe(II), Mn(II), and Zn(II), which are considered to be involved in metal dyshomeostasis during PD. Speciation information regarding the complexes formed by these ions and the 250 compounds has been collected or, if not experimentally available, has been estimated from similar molecules. Stoichiometries and stability constants of the complexes have been reported; values of the cologarithm of the concentration of free metal ion at equilibrium (pM), and of the dissociation constant Kd (both computed at pH = 7.4 and at total metal and ligand concentrations of 10–6 and 10–5 mol/L, respectively), charge and stoichiometry of the most abundant metal–ligand complexes existing at physiological conditions, have been obtained. A rigorous definition of the reported amounts is given, the possible usefulness of this data is described, and the need to characterize the metal–ligand speciation of PD drugs is underlined.

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“…Several bioactive compounds isolated from Psoralea are commercially available. The compounds such as Daidzin (CAS 552-66-9) is a potent inhibitor of human mitochondrial aldehyde dehydrogenase that indicates it chemopreventive property (Keung and Vallee, 1993); Angelicin (CAS 523-50-2) is an antifungal compound (Sardari et al, 2000); 8-Methoxypsoralen (CAS 298-81-7) has been known as a potent suicide inhibitor of cytochrome P-450 (Tinel et al, 1987); Corylifol C and xanthoangelol are potent protein kinase inhibitors and induce apoptotic cell death therefore, possess anti-cancer property ; Bakuchiol (CAS 10309-37-2) is a PTP1B and DNA polymerase inhibitor (Choi et al, 2015); Genistein (CAS 446-72-0) is a highly specific inhibitor of protein tyrosine kinase (Zarmouh et al, 2016); Psoralen has been used as photochemical probe in DNA mutation and repair studies (Gasparro, 1988); and Bavachin (CAS 19879-32-4) stimulates bone formation (anti-osteoporotic activity) Xin et al, 2010). These examples indicate the utility of bioactive compounds isolated from Psoralea species.…”

Section: Discussionmentioning

confidence: 99%

Genus Psoralea: A review of the traditional and modern uses, phytochemistry and pharmacology

Koul

Taak

Kumar

et al. 2019

Journal of Ethnopharmacology

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A B S T R A C TEthnopharmacological relevance: The genus Psoralea (Fabaceae) harbours 105 accepted species that are extensively used by local peoples and medicinal practitioners of China, India, and other countries for treatment of tooth decay, psoriasis, leucoderma, leprosy, kidney problems, tuberculosis, indigestion, constipation and impotence. Presently, pharmacological research reports are available on only few species namely Bituminaria bituminosa (Syn: P. bituminosa), P. canescens, P. corylifolia, P. esculenta, P. plicata and P. glandulosa which are valued for their chemical constituents and traditional uses. Aim of the review: This review article provides explicit information on traditional uses, phytochemistry, and pharmacological activities of selected Psoralea species. The possible trends and perspectives for future research on these plants are also discussed. Materials and methods: An extensive and systematic review of the extant literature was carried out, and the data under various sections were identified using a computerized bibliographic search via the PubMed, Web of Science and Google Scholar, CAB Abstracts, MEDLINE, EMBASE, INMEDPLAN, NATTS as well as several websites. Key findings: A total of 291 bioactive compounds from 06 species of genus Psoralea have been isolated and characterized. However, P. bituminosa alone possess nearly 150 compounds. These bioactive compounds belong to different chemical classes, including flavonoids, coumarins, furanocoumarins, chalcones, quinines, terpenoids and some others due to which these species exhibit significant anti-oxidant, anti-bacterial, anti-fungal, anti-viral, anti-helmintic, anti-diabetic, diuretic, hepatoprotective, anti-cancer and anti-tumor activities. P. corylifolia L. (Babchi), a Chinese traditional medicinal plant has been used in traditional medicine for many decades for its healing properties against numerous skin diseases such as leprosy, psoriasis and leucoderma. Conclusions: The in vitro studies and in vivo models have provided a simple bio-scientific justification for various ethnopharmacological uses of Psoralea species. From the toxicological perspective, the root, leaf, and seed extracts and their preparations have been proven to be safe when consumed in the recommended doses. But, meticulous studies on the pharmaceutical standardization, mode of action of the active constituents, and sustainable conservation of Psoralea species are needed, to meet the growing demands of the pharmaceutical industries, and to fully exploit their preventive and therapeutic potentials.

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Evaluation of the Isoflavone Genistein as Reversible Human Monoamine Oxidase‐A and ‐B Inhibitor

Cited by 34 publications

References 53 publications

MAO-A Inhibitory Potential of Terpene Constituents from Ginger Rhizomes—A Bioactivity Guided Fractionation

MAO-A Inhibitory Potential of Terpene Constituents from Ginger Rhizomes—A Bioactivity Guided Fractionation

Metal Chelation Therapy and Parkinson’s Disease: A Critical Review on the Thermodynamics of Complex Formation between Relevant Metal Ions and Promising or Established Drugs

Genus Psoralea: A review of the traditional and modern uses, phytochemistry and pharmacology

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