Evaluation of the internal fixation effect of nano-calcium-deficient hydroxyapatite/poly-amino acid composite screws for intraarticular fractures in rabbits

Dai, Zhen; Li, Yue; Yan, Yonggang; Wan, Ruijie; Ran, Qiang; Lu, Weizhong; Qiao, Bo; Li, Hong

doi:10.2147/ijn.s173358

Cited by 5 publications

(3 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A second procedure, without doubt, will impose suffering and economic burdens on patients. Recent trends in product offerings have been to accelerate the development of polymer materials (such as collagen, fiber, and polyamino acid) and absorbable inorganic materials (biodegradable ceramics) [ 24 , 101 , 102 , 103 , 104 , 105 ]. However, inevitably, when these artefacts reach the final stages of degradation, biodegradable fixation devices elicit a local foreign-body reaction [ 106 ].…”

Section: New Trendsmentioning

confidence: 99%

Fatigue Crack Growth and Fracture of Internal Fixation Materials in In Vivo Environments—A Review

Guo

2021

Materials

View full text Add to dashboard Cite

The development of crack patterns is a serious problem affecting the durability of orthopedic implants and the prognosis of patients. This issue has gained considerable attention in the medical community in recent years. This literature focuses on the five primary aspects relevant to the evaluation of the surface cracking patterns, i.e., inappropriate use, design flaws, inconsistent elastic modulus, allergic reaction, poor compatibility, and anti-corrosiveness. The hope is that increased understanding will open doors to optimize fabrication for biomedical applications. The latest technological issues and potential capabilities of implants that combine absorbable materials and shape memory alloys are also discussed. This article will act as a roadmap to be employed in the realm of orthopedic. Fatigue crack growth and the challenges associated with materials must be recognized to help make new implant technologies viable for wider clinical adoption. This review presents a summary of recent findings on the fatigue mechanisms and fracture of implant in the initial period after surgery. We propose solutions to common problems. The recognition of essential complications and technical problems related to various approaches and material choices while satisfying clinical requirements is crucial. Additional investigation will be needed to surmount these challenges and reduce the likelihood of fatigue crack growth after implantation.

show abstract

Section: New Trendsmentioning

confidence: 99%

Fatigue Crack Growth and Fracture of Internal Fixation Materials in In Vivo Environments—A Review

Guo

2021

Materials

View full text Add to dashboard Cite

show abstract

“…The limited number of rabbit IAF models reported in the literature generally experience the same shortcomings as rodent IAF models, specifically omission of joint impact during articular fragment creation [56][57][58][59][60][61][62][63][64] or evaluation of joint degeneration without fracture fixation. 61 A recent description of an impact-induced acetabular IAF rabbit model shows great promise as a realistic research tool; however, the authors only qualitatively described the joint degeneration subsequent to the fracture injury.…”

Section: Discussionmentioning

confidence: 99%

A New Method for Creating Impact-Induced Intra-Articular Fractures in a Rabbit Model Induces Severe Post-traumatic Osteoarthritis

Goetz,

Brouillette,

Sakyi

et al. 2024

Journal of Orthopaedic Trauma

View full text Add to dashboard Cite

Objectives: The objective of this work was to develop a model of intra-articular fracture in a rabbit and document the speed and severity of degenerative joint changes after fracture fixation. Methods: With IACUC approval, impact-induced intra-articular fractures were created in the distal tibia of 16 New Zealand White rabbits. Fractures were fixed with a plate and screws. Pain and function were monitored at regular postoperative intervals with limb loading analysis. 12 or 26 weeks after fracture, animals were euthanized for histological assessment of cartilage degeneration and micro-CT analysis of bone histomorphometry. Results: Eleven animals successfully completed the study. Maximum foot force in the fractured limb was 41±21% lower than preoperative values (p=0.006) 12 weeks after fracture and remained 25±13% lower (p=0.081) after 26 weeks. Cortical bone mineral density in micro-CT images was 34±13% lower 12 weeks after fracture (p<0.001) and remained (42±8%) lower 26 weeks after fracture (p<0.001). Twelve weeks after fracture, Mankin scores of cartilage degeneration were significantly higher in the medial talus (p=0.007), lateral talus (p<0.001), medial tibia (p=0.017), and lateral tibia (p=0.002) of the fractured limb compared to the uninjured contralateral limb. Average Mankin scores in the talus increased from 12 to 26 weeks (5.9±0.9 to 9.4±0.4; p<0.001 lateral; 5.4±1.8 to 7.8±2.0; p=0.043 medial), indicating substantial and progressive joint degeneration. Conclusions: The ankle joint of the New Zealand White rabbit provides the smallest available model of impact-induced intra-articular fracture that can be treated with clinically relevant techniques and replicates key features of healing and degeneration found in human patients.

show abstract

“…Композити PGA/PLA були розроблені in vitro, а їх механічні та хімічні властивості були досліджені для розроблення композитів для пристроїв фіксації переломів кісток, що повністю біодеградують [32]. Також була вивчена швидкість біодеградації різних типів полімерних композитів, розроблені кісткові пластини, гвинти й інтрамедулярні стрижні для застосування фіксації та стабілізації опорних переломів довгих кісток [13,26].…”

Section: імпланти що біодеградують: становлення й розвиток переваги та недолікиunclassified

Проблема Використання Композитних Імплантів, Що Біодеградують, У Лікуванні Переломів Кісток (Огляд Літератури)

Павлов¹,

Pastukh²,

Karpinsky³

2021

TRAUMA

View full text Add to dashboard Cite

Diseases and injuries of the musculoskeletal system rank second among the causes of injuries and third among the diseases that lead to disability of the adult population. Orthopedic implants have a special place in both clinical practice and the biomedical industry. The implants capable of biodegrading in the case of their implantation into the human body are of the greatest interest. The concept of biodegra-dable implants appeared through the formation and development of the use of suture materials that are absorbed in the body. Subsequently, this type of material began to be used in the treatment of fractures, because in many cases, bone fragments need only temporary support with a fixator, until they fuse. Implantable internal fixation devices for fracture repair using polyglycolic acid (PGA), polylactic acid (PLA), and a copolymer of lactic acid and glycolide (PLGA) became popular. However, the mechanical properties of highly porous skeletons were relatively weak compared to those required for bone engineering. In the process of creating an optimal polymeric biodegradable material, it is necessary to overcome the contradiction between strength and biodegradation. PGA, providing high strength of fixation, degrade too quickly, and PLGA, having high crystallinity, slightly degrade, at the same time conceding on the durability of both PGA and biostable materials. Scientists are now working hard to develop composites from calcium phosphate and polymer, in particular hydroxyapatite and tricalсium phosphate (TCP). TCP with three polymorphic modifications, in particular α-TCP, β-TCP, and α'-TCP, is a well-known bioceramic substance for bone repair. β-TKP is attracting increasing attention due to its excellent biocompatibility, bioactivity, and biodegradability. The composite materials based on bioactive ceramics mainly refer to materials with additional advantages, such as biodegradable polymers and ceramics. At the same time, these composites are biocompatible, osteoconductive, mechanical strength and have osteogenic characteristics. At the same time, thanks to new manufacturing technologies that have emerged in recent years, these compo-site materials are the most promising in the field of bone defect repair. The treatment of fractures with implants is increasingly associated with composite materials. Biomaterials must have certain mechanical properties: biocompatibility, biodegradation, controlled rate biodegradation, good mechanical strength, and bioactivity. Biomaterials used in the treatment of bone fractures have to disintegrate over time, and the addition of nanofillers can slow down the rate of decay of the biodegradable composite.

show abstract

Evaluation of the internal fixation effect of nano-calcium-deficient hydroxyapatite/poly-amino acid composite screws for intraarticular fractures in rabbits

Cited by 5 publications

References 57 publications

Fatigue Crack Growth and Fracture of Internal Fixation Materials in In Vivo Environments—A Review

Fatigue Crack Growth and Fracture of Internal Fixation Materials in In Vivo Environments—A Review

A New Method for Creating Impact-Induced Intra-Articular Fractures in a Rabbit Model Induces Severe Post-traumatic Osteoarthritis

Проблема Використання Композитних Імплантів, Що Біодеградують, У Лікуванні Переломів Кісток (Огляд Літератури)

Contact Info

Product

Resources

About