Evaluation of the Interaction between Sodium Hypochlorite and Chlorhexidine Gluconate and its Effect on Root Dentin

Bui, Tung B.; Baumgartner, J. Craig; Mitchell, John C.

doi:10.1016/j.joen.2007.11.006

Cited by 152 publications

(204 citation statements)

References 20 publications

Supporting

Mentioning

182

Contrasting

Unclassified

Order By: Relevance

“…This layer may affect close adaptation between root canal filling materials and the root canal walls, interfering in the seal of the root canal filling (8,9). In addition, this precipitate changes the color of the tooth and is cytotoxic (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Effect of Intermediate Flush Using Different Devices to Prevent Chemical Smear Layer Formation

et al. 2017

View full text Add to dashboard Cite

This study compared the effect of intermediate flush with distilled water delivered by conventional irrigation, EndoVac microcannula or Self-Adjusting File (SAF) system in the prevention of chemical smear layer (CSL) formation. Thirty human premolars were used. Canals were prepared with Reciproc system and 5.25% NaOCl. After chemomechanical preparation, samples were divided in 3 groups (n=10) according to the intermediate irrigation protocol with distilled water using: conventional irrigation, EndoVac microcannula or SAF. A final flush with 2% chlorhexidine solution was used and scanning electron microscopy was performed to assess protocol effectiveness. Two calibrated evaluators attributed scores according the presence or absence of CSL on the surface of the root canal walls at the coronal, middle and apical thirds, as follows: (1) no CSL; (2) small amounts of CSL; (3) moderate CSL; and (4) heavy CSL. Differences between protocols were analyzed with Kruskal-Wallis and Mann-Whitney U tests. Friedman and Wilcoxon signed rank tests were used for comparison between each root canal third. SAF resulted in less formation of CSL when compared with the conventional irrigation and EndoVac microcannula (p<0.05). When root canal thirds were analyzed, conventional irrigation and EndoVac groups showed less CSL formation at coronal and middle thirds in comparison to the apical third (p<0.05). In SAF group, there was no difference among the thirds (p>0.05). It may be concluded that an intermediate flush of distilled water, delivered by the SAF system resulted in a better reduction of CSL formation during chemomechanical preparation.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of Intermediate Flush Using Different Devices to Prevent Chemical Smear Layer Formation

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Previous studies have shown the formation of an orange-brown precipitate when CHX is used in combination with NaOCl (126)(127)(128)(129). This solid precipitate produced may occlude the dentinal tubules and form a barrier between the filling material and dentin surface and therefore increase the risk of microleakage (127,130).…”

Section: Chlorhexidinementioning

confidence: 99%

Bioactive Chitosan Nanoparticles and Photodynamic Therapy Inhibit Collagen Degradation In Vitro

Persadmehr

Torneck

Cvitkovitch

et al. 2014

Journal of Endodontics

View full text Add to dashboard Cite

This study evaluated the ability of photodynamic therapy (PDT), chitosan nanoparticles (CSnp), or their combination, to inhibit bacterial collagenase-mediated degradation of collagen. Rat type 1 fibrillar collagen matrices were untreated or treated with 2.5% glutaraldehyde (GD), 2.5% GD followed by 1% CSnp, 1% CSnp, PDT, or 1% CSnp followed by PDT. Samples, except untreated controls, were exposed to Clostridium histolyticum collagenase. The soluble digestion products were assessed by hydroxyproline assay and the remaining adherent collagen was quantified by picrosirius red (PSR) staining. Collagen treated with CSnp, PDT, or a combination of CSnp and PDT, exhibited less degradation than controls. The abundance of post-treatment residual collagen correlated with the extent of degradation. Fourier transform infrared (FTIR) spectroscopy analysis showed that PDT treatment enhanced collagen cross-linking.Immunoblotting of sedimented CSnp indicated that CSnp and collagenase bound with low affinity. However, CSnp-bound collagenase showed a significant reduction in collagenolytic activity compared with controls.III

show abstract

“…This reaction product covers the surfaces of root canals, blocking the dentinal tubules and compromising the root canal seal (19).…”

Section: Interactions Of Naoclmentioning

confidence: 99%

“…As with other endodontic disinfectants, however, these effects are greatly reduced in the presence of organic matter, as the activity of CHX is dependent on pH (38). Although CHX kills bacteria, it is ineffective in removing biofilm and other organic substances (19). A 2% solution of CHX is appropriate to achieve the desired maximal antibacterial effect at the end of chemomechanical preparation.…”

Section: Chlorhexidine (Chx)mentioning

confidence: 99%

Endodontic Irrigation Solutions: A Review

Topbaş

Adıgüzel

2017

Int Dent Res

View full text Add to dashboard Cite

The goal of endodontic treatment is to remove all the vital and necrotic tissues, microorganisms and microbial byproducts from root canal system. This goal can be achieved through chemical and mechanical debridement of root canals. This article narrates the specifics and requirements of the irrigation solutions. Sodium hypochlorite is proposed as the primary irrigant by virtue of its organic tissue dissolution capacity and broad antimicrobial properties. On the other hand, chelation solutions are recommended as auxiliary solutions to remove the smear layer or to hinder its formation on dentin surface. Thus, it's hoped that sealers and root canal fillers can penetrate to dentin tubules and obturate the canals hermetically. There are new studies on traditional irrigants especially on some irrigants that can replace sodium hypoclorite. This article reviews the new irrigants which can be used in future endodontic practice, and their advantages and limitations. Moreover, actions and interactions of recently used irrigants are adverted.

show abstract

Evaluation of the Interaction between Sodium Hypochlorite and Chlorhexidine Gluconate and its Effect on Root Dentin

Cited by 152 publications

References 20 publications

Effect of Intermediate Flush Using Different Devices to Prevent Chemical Smear Layer Formation

Effect of Intermediate Flush Using Different Devices to Prevent Chemical Smear Layer Formation

Bioactive Chitosan Nanoparticles and Photodynamic Therapy Inhibit Collagen Degradation In Vitro

Endodontic Irrigation Solutions: A Review

Contact Info

Product

Resources

About