Evaluation of the insulin application system Autopen 24®

Abstract

In patients with insulin therapy, a simple to use, reliable and safe insulin application device is a prerequisite to achieve good glucose control, and for reducing and avoiding progression of secondary complications. Modern injection pen systems provide the patient with a high degree of flexibility and quality of life. However, the integration of further and appropriate therapeutic aids into a device can make a positive contribution to compliance and therapy satisfaction. In this multicentre, open, randomised, three‐month, cross‐over study, the new insulin application device Autopen 24® (designed for Sanofi‐Aventis insulin cartridges) was evaluated in comparison to the established OptiPen® Pro device with regard to clinical efficacy (HbA1c, frequency of severe hypoglycaemic episodes) and patients' preference and acceptance in 40 patients (20 women, 20 men; 20 type 1, 20 type 2; age [mean±SD] 49.3±15.1 years; BMI 29.0±5.0 kg/m2). No differences were seen regarding HbA1c and hypoglycaemic episodes between the treatment groups. The Autopen 24 showed a high level of acceptance by patients in comparison to OptiPen Pro and was preferred by older patients with type 2 diabetes. In conclusion, Autopen 24 is a suitable alternative to other injection devices in patients with diabetes mellitus treated with Sanofi‐Aventis insulin products. Copyright © 2005 John Wiley & Sons, Ltd.

The Review of Insulin Pens—Past, Present, and Look to the Future

“…With time, the option of insulin-free dialing forward and backward became a prevailing way of setting the insulin doses. All mentioned insulin pens had the trigger placed at on the opposite site of the needle attach end, but there are also insulin pens with a side-mounted release button used for half-automatic insulin delivery, first developed in AutoPen ( 44 ), and this mechanism was also present later on in 2010 in GensuPen ® and in 2017 in GensuPen ® 2 insulin pens ( 27 , 45 ). Such a mechanism ensured patients about proper insulin administration, simplified the way of injection, and was convenient for elderly patients ( 27 ).…”